4alpha-甲基-5alpha-胆甾-8(14)-烯-3beta-醇 | 62014-96-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 4alpha-甲基-5alpha-胆甾-8(14)-烯-3beta-醇
• 英文名称: 4α-methyl-5α-cholest-8(14)-en-3β-ol
• 英文别名: 4α-methylcholest-8(14)-en-3β-ol；4α-methylcholest-8(14)-enol；4alpha-Methyl-5alpha-cholest-8(14)-en-3beta-ol；(3S,4S,5S,9R,10S,13R,17R)-4,10,13-trimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 62014-96-4
• 化学式: C₂₈H₄₈O
• 分子量: 400.689
• InChiKey: UIPYFONRKZTOIY-GQZGFCDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4alpha-甲基-5alpha-胆甾-8(14)-烯-3beta-醇 、 苯甲酰氯 生成 3β-benzoyloxy-4α-methyl-5α-cholest-8(14)-ene
  参考文献：
  名称：

  The Neutral Constituents of the Cactus Lophocereus schottii. The Structure of Lophenol--4α-Methyl-Δ⁷-cholesten-3β-ol--A Link in Sterol Biogenesis^1-3

  摘要：

  DOI：

  10.1021/ja01556a031
• 作为产物：
  描述：

  烯胆固烷酮 在 platinum(IV) oxide potassium tert-butylate 、 氢气 作用下， 以 溶剂黄146 为溶剂， 生成 4alpha-甲基-5alpha-胆甾-8(14)-烯-3beta-醇
  参考文献：
  名称：

  Novel nuclear methylation of sterols by the nematode caenorhabditis elegans

  摘要：

  Caenorhabditis elegans possesses a unique sterol methylation pathway not reported to occur in any other organism and also removes the C-24 ethyl group of sitosterol (a plant sterol). This nematode produced substantial quantities of 4 alpha-methyl-5 alpha-cholest-8(14)-en-3 beta-ol and smaller amounts of lophenol from dietary cholesterol, desmosterol or sitosterol. When C. elegans was propagated in media containing sitosterol plus 25-azacoprostane hydrochloride (25-aza-5 beta-cholestane hydrochloride), an inhibitor of delta 24-sterol reductase in insects, its 4 alpha-methylsterol fraction largely consisted of equal amounts of 4 alpha-methyl-5 alpha-cholesta-7,24-dien-3 beta-ol and 4 alpha-methyl-5 alpha-cholesta-8(14),24-dien-3 beta-ol. Thus 25-azacoprostane hydrochloride inhibited both a delta 24-sterol reductase and a delta 7-sterol isomerase in C. elegans.

  DOI：

  10.1016/0039-128x(83)90042-9

文献信息

• Novel anti-nematode therapies targetting STRM-1
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2269630A1

  公开（公告）日：2011-01-05

  The present invention relates to a compound for use as an anti-helminthic agent, said compound being selected from (i) a compound interfering with the transcription or translation of a nucleic acid sequence encoding a polypeptide having a function of introducing a methyl group at a specific position into the sterol nucleus of a sterol which nucleic acid sequence is (a) a nucleic acid sequence encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid sequence comprising or consisting of the sequence of SEQ ID NO: 2; (c) a nucleic acid sequence which encodes a polypeptide which is at least 70% identical to the sequence of SEQ ID NO: 1;(d) the nucleic acid sequence of (b) wherein T is U; (e) a nucleic acid sequence hybridizing to the complementary strand of a nucleic acid molecule of any of (a) to (d); or (f) a nucleic acid sequence being degenerate to the sequence of the nucleic acid molecule of (d) or (e), wherein said compound is an antisense molecule, siRNA, shRNA, miRNA, aptamer, antibody or a ribozyme, and (ii) a compound interfering with the function of the polypeptide encoded by the nucleic acid sequence of (i) said compound being an antibody, enzyme, peptide or a small organic molecule.

  本发明涉及一种用作抗蠕虫剂的化合物，所述化合物选自(i)干扰编码多肽的核酸序列的转录或翻译的化合物，该多肽具有在特定位置将甲基基团引入甾醇核的功能，其核酸序列为(a)编码多肽的核酸序列，该多肽包括或由SEQ ID NO.1的氨基酸序列组成；(b)编码多肽的核酸序列，该多肽包括或由SEQ ID NO.2的氨基酸序列组成；(c)编码多肽的核酸序列，该多肽与SEQ ID NO.3的氨基酸序列至少70％相同：1 的氨基酸序列组成的多肽的核酸序列；(b) 由 SEQ ID NO: 2 的序列组成的核酸序列；(c) 编码与 SEQ ID NO：1；(d) (b)的核酸序列，其中 T 为 U；(e) 与(a)至(d)中任何一项的核酸分子的互补链杂交的核酸序列；或 (f) 与(d)或(e)的核酸分子序列变性的核酸序列，其中所述化合物是反义分子、 siRNA、shRNA、miRNA、aptamer、抗体或核酶，以及 (ii) 干扰由(i)的核酸序列编码的多肽功能的化合物，所述化合物是抗体、酶、肽或小有机分子。
• COMPOSITION CONTAINING CAPSICUM FOR TREATING A SKIN DISORDER
  申请人：Rezai-Fard, Ali

  公开号：EP2262516A2

  公开（公告）日：2010-12-22
• Composition for Treating a Skin Disorder
  申请人：Rezai-Fard Ali

  公开号：US20110046080A1

  公开（公告）日：2011-02-24

  The present invention relates to the use of a plant of the genus, Capsicum , or part thereof or extract thereof for treating or alleviating the symptoms of a skin condition or disorder, including dermatitis. The present invention also relates to compositions comprising the same for such use, together with methods of treating or alleviating the symptoms of eczema or dermatitis.
• [EN] COMPOSITION FOR TREATING A SKIN DISORDER<br/>[FR] COMPOSITION POUR TRAITER UN TROUBLE DE LA PEAU
  申请人：REZAI-FARD ALI

  公开号：WO2009090394A2

  公开（公告）日：2009-07-23

  The present invention relates to the use of a plant of the genus, Capsicum, or part thereof or extract thereof for treating or alleviating the symptoms of a skin condition or disorder, including dermatitis. The present invention also relates to compositions comprising the same for such use, together with methods of treating or alleviating the symptoms of eczema or dermatitis.
• [EN] NOVEL ANTI-HELMINTHIC THERAPIES<br/>[FR] NOUVELLES THÉRAPIES ANTI-HELMINTHIQUES
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2010146062A2

  公开（公告）日：2010-12-23

  The present invention relates to a compound for use as an anti-helminthic agent, said compound being selected from (i) a compound interfering with the transcription or translation of a nucleic acid sequence encoding a polypeptide having a function of introducing a methyl group at a specific position into the sterol nucleus of a sterol which nucleic acid sequence is (a) a nucleic acid sequence encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid sequence comprising or consisting of the sequence of SEQ ID NO: 2; (c) a nucleic acid sequence which encodes a polypeptide which is at least 70% identical to the sequence of SEQ ID NO: 1;(d) the nucleic acid sequence of (b) wherein T is U; (e) a nucleic acid sequence hybridizing to the complementary strand of a nucleic acid molecule of any of (a) to (d); or (f) a nucleic acid sequence being degenerate to the sequence of the nucleic acid molecule of (d) or (e), wherein said compound is an antisense molecule, siRNA, shRNA, miRNA, aptamer, antibody or a ribozyme, and (ii) a compound interfering with the function of the polypeptide encoded by the nucleic acid sequence of (i) said compound being an antibody, enzyme, peptide or a small organic molecule.