asparginic acid disodium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: asparginic acid disodium salt
• 英文别名: disodium salt of asparic acid；sodium aspartate；aspartic acid disodium salt；sodium polyaspartate；sodium;2-aminobutanedioate
• 化学式: C₄H₅NO₄*2Na
• 分子量: 177.068
• InChiKey: WTWSHHITWMVLBX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.79
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  asparginic acid disodium salt 、 copper(II) sulfate 在 水 作用下， 以 水 为溶剂， 生成 Na2{Cuasp2}*nH2O
  参考文献：
  名称：

  Lifschitz, I.; Schouteden, F. L. M., Recueil des Travaux Chimiques des Pays-Bas, 1939, vol. 58, p. 411 - 422

  摘要：

  DOI：
• 作为产物：
  描述：

  在 水 、 carbamoyl phosphate 作用下， 以 various solvent(s) 为溶剂， 反应 0.17h， 生成 Methylendiphosphoniumsaeure-tetranatriumsalz 、 asparginic acid disodium salt
  参考文献：
  名称：

  天冬氨酸转氨酶的双底物，过渡态类似物和竞争性抑制剂的设计，合成和活性。

  摘要：

  天冬氨酸转氨酶起始了从头开始的生物合成途径，以产生嘧啶核苷酸，核酸的前体。该途径在迅速生长的细胞和组织中特别活跃。因此，已经将该酶作为抗增殖药的潜在靶标进行了测试。在目前的工作中，基于其结构和力学性能，合成了一系列底物类似物，包括潜在的自杀性假底物，并使用大肠杆菌天冬氨酸转氨酶作为模型测试了其假定的抑制作用。这些化合物中的两种似乎是该酶的非常有效的抑制剂。

  DOI：

  10.1016/j.ejmech.2004.01.006

文献信息

• N-formylation of amino carboxylates with alkyl formates
  申请人：W. R. Grace & Co.-Conn.

  公开号：US04801742A1

  公开（公告）日：1989-01-31

  Formylating the amino nitrogen of an alkali metal salt of an amino carboxylic acid, by reacting the salt with an alkyl formate in an alkanol solvent. In one embodiment, the alkyl formate is added to the reaction as such; in another embodiment, the alkyl formate is formed in situ by reaction of carbon monoxide with the alkanol solvent in the presence of the alkali metal salt of the amino carboxylic acid. The process provides a new class of compounds, the alkali metal salts of N-formyl-aspartic acids.

  通过将氨基羧酸的碱金属盐与烷基甲酸酯在烷醇溶剂中反应，对氨基碱金属盐的氨基氮进行甲酰化。在一种实施例中，烷基甲酸酯直接加入反应中；在另一种实施例中，通过在碱金属盐的氨基羧酸存在下，将一氧化碳与烷醇溶剂反应形成烷基甲酸酯。该过程提供了一类新的化合物，即N-甲酰天冬氨酸的碱金属盐。
• Process for the preparation of stilbene compounds
  申请人：Ciba Specialty Chemical Corporation

  公开号：US06365737B1

  公开（公告）日：2002-04-02

  A process for the preparation of a 4,4′-bis-(triazinylamino)-stilbene-2,2′-disulphonic acid compound of formula (1) is disclosed, characterized in that (a) in a first reaction step cyanurchloride is reacted with the disodium salt of 4,4′-diaminostilbene-2,2′-disulfonic acid to give the intermediate of formula (2); (b) in a second reaction step the compound of formula (2) is reacted with a compound of formula R1—H and/or R2—H to give the compound of formula (3); (c) in a third step the compound of formula (3) is reacted with the compound of the formula R3H, and reaction step (a) and/or (c) are carried out in a medium consisting of a mixture of water and a polyglycol to give the compound of formula (1), wherein R1, R2 and R3, independently, are phenylamino; phenylamino substitued by C1-C3alkyl, halogen, cyano, COOR or COR; CONH—R; SO2NH—R; NH—COR; mono- or disulphonated phenylamino; morpholino; piperidino; pyrrolidino; —NH2; —NH(C1-C4alkyl); —N(C1-C4alkyl)2; —NH(C2-C4hydroxyalkyl); —N(C2-C4hydroxyalkyl)2; —N(C1-C4alkyl)(C2-C4hydroxyalkyl); NHC2-C4 alkylsulphonic acid; —OC1-C4alkyl; an aminoacid or aminoacid amide residue from which a hydrogen atom on the amino group has been removed; R1 and R2 may further independently represent hydrogen; C1-C4alkyl; phenyl; naphthyl; phenyl or naphthyl substituted by C1-C4alkyl, C1-C4alkoxy, halogen, C2-C5alkanoyl-amino, nitro, sulpho or C1-C4alkylated amino; R is hydrogen; or C1-C3alkyl; and M is H, Na, Li, K, Ca, Mg, ammonium, or ammonium that is mono-, di-, tri- or tetrasubstituted by C1-C4alkyl, C2-C4hydroxyalkyl or a mixture thereof.

  公开了一种制备化合物的方法，该化合物为4,4′-双-(三嗪基氨基)-亚苄-2,2′-二磺酸化合物，其化学式为（1），其特征在于：（a）在第一反应步骤中，氰尿氯脲与4,4′-二氨基亚苄-2,2′-二磺酸二钠盐反应，得到化学式（2）的中间体；（b）在第二反应步骤中，化合物（2）与化学式为R1—H和/或R2—H的化合物反应，得到化学式（3）的化合物；（c）在第三步中，化学式（3）的化合物与化学式为R3H的化合物反应，反应步骤（a）和/或（c）在由水和聚乙二醇混合而成的介质中进行，得到化学式（1）的化合物，其中R1、R2和R3独立地为苯基氨基；被C1-C3烷基、卤素、氰基、COOR或COR取代的苯基氨基；CONH—R；SO2NH—R；NH—COR；单磺化或双磺化的苯基氨基；吗啉基；哌啶基；吡咯啉基；—NH2；—NH(C1-C4烷基)；—N(C1-C4烷基)2；—NH(C2-C4羟基烷基)；—N(C2-C4羟基烷基)2；—N(C1-C4烷基)(C2-C4羟基烷基)；NHC2-C4烷基磺酸；—OC1-C4烷基；氨基酸或氨基酸酰胺残基，氨基团上的氢原子已被去除；R1和R2还可以独立地表示氢；C1-C4烷基；苯基；萘基；被C1-C4烷基、C1-C4烷氧基、卤素、C2-C5烷酰胺基、硝基、磺酸基或C1-C4烷基化氨基取代的苯基或萘基；R为氢；或C1-C3烷基；M为H、Na、Li、K、Ca、Mg、铵离子或经C1-C4烷基、C2-C4羟基烷基或两者混合物单取代、双取代、三取代或四取代的铵离子。
• Object Identification system with adaptive transceivers and methods of operation
  申请人：RF Code, Inc.

  公开号：US06362737B1

  公开（公告）日：2002-03-26

  An object identification system includes a monitor and a plurality of transceivers that communicate over a common medium. The monitor includes a first transmitter, a first receiver, and a processor. Each transceiver includes a resonant circuit, a transmitter, a receiver, and an antenna coupled to the resonant circuit. The processor performs a method for performing transceiver communication that includes the steps of: (a) transmitting from the first transmitter a first frequency for a first duration; (b) after lapse of the first duration, receiving via the first receiver a response signal from at least one of the resonant circuits; (c) determining a second frequency from the received response signal; and (d) performing transceiver communication using the second frequency. Transceivers of the type having a resonant circuit coupled to an antenna, when operating in close proximity to each other, may interfere with the response from a single transceiver by absorbing the energy intended to be received by the transceiver, absorbing the energy transmitted by the transceiver, or altering the resonant frequency of the resonant circuit. By determining the second frequency for transceiver communication, the monitor may establish communication with the single transceiver at a frequency better suited for transferring operative power to the transceiver, conducting an interrogation protocol for identifying the transceiver, or for data transfer.

  一个物体识别系统包括一个监视器和多个通过共同介质通信的收发器。监视器包括第一个发射器、第一个接收器和处理器。每个收发器包括一个谐振电路、一个发射器、一个接收器和与谐振电路耦合的天线。处理器执行用于执行收发器通信的方法，包括以下步骤：(a)从第一个发射器发送第一个频率，持续第一个时间段；(b)在第一个时间段结束后，通过第一个接收器接收至少一个谐振电路的响应信号；(c)从接收到的响应信号中确定第二个频率；(d)使用第二个频率执行收发器通信。当具有与天线耦合的谐振电路的收发器类型在彼此紧邻的情况下运行时，可能会通过吸收原本应该被收发器接收的能量、吸收收发器发送的能量或改变谐振电路的谐振频率来干扰单个收发器的响应。通过确定用于收发器通信的第二个频率，监视器可以与单个收发器建立通信，在更适合传输操作功率给收发器、执行用于识别收发器的询问协议或进行数据传输的频率上。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cu: MVol.B4, 100, page 1654 - 1656
  作者：

  DOI：——

  日期：——
• PLATINUM COMPOUND HAVING AMINO- OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Beijing Fswelcome Technology Development Co., Ltd

  公开号：EP2759547B1

  公开（公告）日：2017-01-18