triethylenetetramine disuccinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: triethylenetetramine disuccinate
• 英文别名: N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;butanedioic acid
• 化学式: 2C₄H₆O₄*C₆H₁₈N₄
• 分子量: 382.414
• InChiKey: IOGZANMGHWGQPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.98
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  151
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  triethylenetetramine disuccinate 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以6.3 g的产率得到三乙烯四胺
  参考文献：
  名称：

  METHOD FOR TRIETHYLENETETRAMINE PURIFICATION

  摘要：

  Methods for the purification of impure triethylenetetramine into highly pure triethylenetetramine are described. In particular, methods for the preparation of relatively pure salts of triethylenetetramine starting from crude triethylenetetramine and crude salts of trethylenetetramine are described.

  公开号：

  US20240043370A1
• 作为产物：
  描述：

  丁二酸 、 1,3-bis-(2-benzylidenamino-ethyl)-2-phenyl-imidazolidine 在 甲醇 作用下， 以 水 、 异丙醇 为溶剂， 50.0 ℃ 、10.0 kPa 条件下， 以93.1%的产率得到triethylenetetramine disuccinate
  参考文献：
  名称：

  Synthesis of triethylenetetramines

  摘要：

  合成三乙烯四胺及其盐的方法和中间体，以及新型三乙烯四胺盐及其晶体结构，以及高纯度的三乙烯四胺盐。

  公开号：

  US20060041170A1

文献信息

• Synthesis Of Triethylenetetramines
  申请人：Jonas Marco

  公开号：US20120029203A1

  公开（公告）日：2012-02-02

  Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

  合成三乙烯四胺及其盐的方法和中间体，以及新型三乙烯四胺盐及其晶体结构，以及高纯度的三乙烯四胺盐。
• TREATMENT OF MITOCHONDRIA-RELATED DISEASES AND IMPROVEMENT OF AGE-RELATED METABOLIC DEFICITS
  申请人：Cooper Garth James Smith

  公开号：US20130108709A1

  公开（公告）日：2013-05-02

  Pharmaceutical compositions and methods for the treatment of subjects, including humans, who have or are at risk for various disease, disorders and conditions, including, mitochondria-associated diseases, disorders, and conditions, including respiratory chain disorders, and diseases, disorders and conditions associated with or characterized at least in part by mitochondria swelling, mitochondria dysfunction, mitochondria leaking, oxidative stress, increased mitochondria number, increased mitochondria and mitochondria-related protein mass, and increased mitochondria and related-related proteins expression.

  药物组合物和治疗方法，用于治疗患有或有风险患有各种疾病、疾病和疾病的受试者，包括线粒体相关疾病、疾病和疾病，包括呼吸链障碍，以及与线粒体肿胀、线粒体功能障碍、线粒体泄漏、氧化应激、线粒体数量增加、线粒体和线粒体相关蛋白质质量增加以及线粒体和相关蛋白质表达增加至少部分有关的疾病、疾病和疾病。
• Synthesis of Triethylenetetramines
  申请人：PhilEra New Zealand Limited

  公开号：US20150057466A1

  公开（公告）日：2015-02-26

  Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

  合成三乙烯四胺及其盐的方法和中间体，以及新型三乙烯四胺盐及其晶体结构和高纯度的三乙烯四胺盐。
• Treatment of Mitochondria-Related Diseases and Improvement of Age-Related Metabolic Deficits
  申请人：COOPER Garth James, Smith

  公开号：US20150196500A1

  公开（公告）日：2015-07-16

  Pharmaceutical compositions and methods for the treatment of subjects, including humans, who have or are at risk for various disease, disorders and conditions, including, mitochondria-associated diseases, disorders, and conditions, including respiratory chain disorders, and diseases, disorders and conditions associated with or characterized at least in part by mitochondria swelling, mitochondria dysfunction, mitochondria leaking, oxidative stress, increased mitochondria number, increased mitochondria and mitochondria-related protein mass, and increased mitochondria and related-related proteins expression.

  药物组合物和方法，用于治疗患有或有患各种疾病，疾病和疾病的风险，包括与线粒体相关的疾病，疾病和疾病，包括呼吸链疾病，以及与线粒体肿胀，线粒体功能障碍，线粒体泄漏，氧化应激，线粒体数量增加，线粒体和线粒体相关蛋白质质量增加，以及线粒体和相关蛋白质表达增加至少部分相关的疾病，疾病和疾病。
• High concentration surfactant compositions and methods
  申请人：Otterson John Richard

  公开号：US20050037942A1

  公开（公告）日：2005-02-17

  A high concentration, aqueous liquid surfactant composition is disclosed, comprising at least one amphoteric or anionic surfactant and a liquid-stabilizing amount of at least one liquid-stabilizing agent. The liquid-stabilizing agent is a succinic acid derivative, glutaric acid derivative or a combination thereof. The composition is pourable and pumpable at ambient room temperature.

  本发明公开了一种高浓度水性液体表面活性剂组合物，它包含至少一种两性表面活性剂或阴离子表面活性剂和至少一种液体稳定剂的液体稳定剂。液体稳定剂是琥珀酸衍生物、戊二酸衍生物或它们的组合。该组合物在室温下可浇注和泵送。