3,4-双(三甲基硅氧基)苯甲醛 | 10586-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,4-双(三甲基硅氧基)苯甲醛
• 英文名称: 3,4-bis(trimethylsiloxy)-benzaldehide
• 英文别名: 3,4-bis(trimethylsilyloxy)benzaldehyde；3,4-bis(trimethylsiloxy)benzaldehyde；3,4-Bis((trimethylsilyl)oxy)benzaldehyde
• CAS: 10586-13-7
• 化学式: C₁₃H₂₂O₃Si₂
• 分子量: 282.487
• InChiKey: SUXBXVBGVLEZAU-UHFFFAOYSA-N

物化性质

• 保留指数：
  1618

计算性质

• 辛醇/水分配系数(LogP)：
  3.93
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-双(三甲基硅氧基)苯甲醛 在 氯化铵 、 diborane(6) 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 83.0h， 生成 leudrin
  参考文献：
  名称：

  Vitamin C in organic synthesis: reaction with p-hydroxybenzyl alcohol derivatives

  摘要：

  DOI：

  10.1021/jo00242a037
• 作为产物：
  描述：

  三甲基氯硅烷 、 3,4-二羟基苯甲醛 在 吡啶 作用下， 以 苯 为溶剂， 生成 3,4-双(三甲基硅氧基)苯甲醛
  参考文献：
  名称：

  Reimann,E., Justus Liebigs Annalen der Chemie, 1971, vol. 750, p. 109 - 127

  摘要：

  DOI：

文献信息

• Synthesis of 2-hydroxy-2-phenylethylamino derivatives as potential α-adrenergic blocking agents
  作者：M. Alvarez、R. Granados、R. Lavilla、M. Salas

  DOI：10.1002/jhet.5570220326

  日期：1985.5

  synthesis of N,N'-bis[6-(2-hydroxy-2-phenylethylamino)hexyl] cystamines 4, and N-(2-hydroxy-2-phenylethyl)-1,6-hexanediamines 6 are described. Compounds 4 were obtained by condensation of the requisite epoxide 2 with 3-(6-aminohexyl)-1,3-thiazolidine followed by dimerization with opening of the thiazolidine ring. A similar method was used for the preparation of compounds 6. In order to prepare 4j (N,N'-bis6-[2-hydroxy-2(3

  合成N，N'-双[6-（2-羟基-2-苯乙氨基）己基] cystamines 4，和N-（2-羟基-2-苯乙基）-1,6- hexanediamines 6中描述。通过将必需的环氧化物2与3-（6-氨基己基）-1，3-噻唑烷缩合，然后通过打开噻唑烷环进行二聚来获得化合物4。用类似的方法制备化合物6。为了制备4j（N，N′-双6- [2-羟基-2（3，4-二羟基苯基）乙基氨基]己基}胱胺），有几种方法。经过测试 选择的方法涉及使用两个羟基都被保护为甲氧基甲基醚的3，4-二羟基苯甲醛。
• Steynberg, Jan P.; Ferreira, Daneel; Roux, David G., Journal of the Chemical Society. Perkin transactions I, 1987, p. 1705 - 1712
  作者：Steynberg, Jan P.、Ferreira, Daneel、Roux, David G.

  DOI：——

  日期：——
• Cyclic ions in the mass spectra of trimethylsilyl derivatives of substitutedo-dihydroxybenzenes
  作者：Robert J. Horvat、Samuel D. Senter

  DOI：10.1002/oms.1210181002

  日期：1983.10

  AbstractThe mass spectra of trimethylsilyl (TMS) ethers/methyl esters of phenolic acids containing o‐dihydroxybenzene groups have base peaks at [M−119]+ instead of the usual [M−15]+ and [M−31]+ that are characteristic of TMS/methyl esters of monohydroxyphenolic acids. These ions, formed by the loss of 31+88 u from the parent ion, possess a cyclic moiety as proven by substitution of deuterium atoms for hydrogen atoms in the TMS groups of the methyl esters of 3,4,5‐trihydroxybenzoic (gallic), 3,4‐dihydroxybenzoic (protocatechuic) and β‐(3,4‐dihydroxyphenyl)propenoic (caffeic) acids. Although these cyclic ions are the base peaks in TMS‐derivatized o‐dihydroxyphenolic acid esters, similar ions represent intense peaks but not necessarily the base peak in other derivatized compounds such as 1,2‐dihydroxybenzene, 1,2‐dihydroxy‐3‐methyl‐ and 1,2‐dihydroxy‐4‐methyl‐benzenes and flavan‐3‐ols that possess o‐dihydroxybenzene groups. Compounds possession m‐ or p‐dihydroxybenzene groups do not form these cyclic ions; therefore, this procedure for derivatization and interpretation of mass spectra is valuable for the identification of compounds containing o‐dihydroxybenzene groups in complex mixtures of isomeric compounds.
• STEYNBERG, JAN P.;FERREIRA, DANEEL;ROUX, DAVID G., J. CHEM. SOC. PERKIN TRANS.,(1987) N 8, 1705-1712
  作者：STEYNBERG, JAN P.、FERREIRA, DANEEL、ROUX, DAVID G.

  DOI：——

  日期：——
• POSS, ANDREW J.;BELTER, RANDOLPH K., J. ORG. CHEM., 53,(1988) N 7, 1535-1540
  作者：POSS, ANDREW J.、BELTER, RANDOLPH K.

  DOI：——

  日期：——