2,6-二溴-N,N-二甲基吡啶-4-胺 | 192447-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二溴-N,N-二甲基吡啶-4-胺
• 英文名称: 2,6-dibromo-4-(dimethylamino)pyridine
• 英文别名: 2,6-dibromo-N,N-dimethylpyridin-4-amine
• CAS: 192447-58-8
• 化学式: C₇H₈Br₂N₂
• 分子量: 279.962
• InChiKey: DPFRJHTWUCTTEI-UHFFFAOYSA-N

物化性质

• 沸点：
  342.6±37.0 °C(Predicted)
• 密度：
  1.829±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H312,H315,H319,H332,H335
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  2,6-二溴-N,N-二甲基吡啶-4-胺 在 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.0h， 生成 1-(4-dimethylamino-6-methylpyridin-2-yl)-2,2,2-trifluoroethanol
  参考文献：
  名称：

  O-Nucleophilic Amino Alcohol Acyl-Transfer Catalysts:  the Effect of Acidity of the Hydroxyl Group on the Activity of the Catalyst

  摘要：

  [GRAPHIC]Amino alcohol-derived acyl-transfer catalysts are shown to operate by an O-nucleophilic mechanism, and catalysts bearing electron-withdrawing groups in proximity to the hydroxyl group are found to be more active. This is attributed to an increase in the acidity of the hydroxyl group of the catalyst.

  DOI：

  10.1021/ol035510n
• 作为产物：
  描述：

  4-二甲氨基吡啶 在 三氟化硼乙醚 、 溴 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以23%的产率得到2,6-二溴-N,N-二甲基吡啶-4-胺
  参考文献：
  名称：

  O-Nucleophilic Amino Alcohol Acyl-Transfer Catalysts:  the Effect of Acidity of the Hydroxyl Group on the Activity of the Catalyst

  摘要：

  [GRAPHIC]Amino alcohol-derived acyl-transfer catalysts are shown to operate by an O-nucleophilic mechanism, and catalysts bearing electron-withdrawing groups in proximity to the hydroxyl group are found to be more active. This is attributed to an increase in the acidity of the hydroxyl group of the catalyst.

  DOI：

  10.1021/ol035510n

文献信息

• N-(unsubstituted or substituted)-4-substituted-6-(unsubstituted or substituted)phenoxy-2-pyridinecarboxamides or thiocarboxamides, processes for producing the same, and herbicides
  申请人：Kureha Kagaku Kogyo Kabushiki Kaisha

  公开号：US06339045B1

  公开（公告）日：2002-01-15

  N-(substituted or unsubstituted)-4-substituted-6-(substituted or unsubstituted) phenoxy-2-pyridine carboxamide or thiocarboxamide represented by the general formula (I) and a process for producing the compound. A herbicide containing as an effective ingredient N-(substituted or unsubstituted)-4-substituted-6-(substituted or unsubstituted) phenoxy-2-pyridine carboxamide or thiocarboxamide represented by the general formula (I).

  N-(取代或未取代)-4-取代-6-(取代或未取代)苯氧基-2-吡啶羧酰胺或硫代羧酰胺，其通式表示为(I)，以及制备该化合物的方法。 包含N-(取代或未取代)-4-取代-6-(取代或未取代)苯氧基-2-吡啶羧酰胺或硫代羧酰胺，其通式表示为(I)，作为有效成分的除草剂。
• METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES
  申请人：Martineau Louis C.

  公开号：US20140135359A1

  公开（公告）日：2014-05-15

  The present invention provides a computer-assisted method of generating a protonophore requiring the use of a computer including a processor. The method includes: designing the protonophore, calculating, using the processor, an estimated protonophoric activity; producing the protonophore if the estimated protonophoric activity corresponds to an U 50 of about 20 μM or less; and determining the uncoupling activity of the protonophore. The present invention also provides novel protonophores that meet the above requirement and their methods of use.

  本发明提供了一种利用计算机辅助的方法来生成需要使用处理器的质子载体。该方法包括：设计质子载体，使用处理器计算估计的质子载体活性；如果估计的质子载体活性对应于大约20微米或更少的U50，则生产质子载体；并确定质子载体的解耦活性。本发明还提供了符合上述要求的新型质子载体及其使用方法。
• Methoxy-substituted bis-tridentate iridium(<scp>iii</scp>) phosphors and fabrication of blue organic light emitting diodes
  作者：Wun-Shan Tai、Ling-Yang Hsu、Wen-Yi Hung、Yi-Yang Chen、Chang-Lun Ko、Xiuwen Zhou、Yi Yuan、Alex K.-Y. Jen、Yun Chi

  DOI：10.1039/d0tc03453c

  日期：——

  Both monoanionic dicarbene pincer chelate and dianionic azole-pyridine-carbazole cyclometalate were successfully employed in the preparation of respective bis-tridentate Ir(iii) metal complexes (Cz6–9) in moderate yields.

  单阴离子二碳烯夹持螯合物和双阴离子咪唑-吡啶-咔唑环金属配体成功用于制备相应的双三齿Ir(iii)金属配合物（Cz6–9），产率适中。
• 6-(Nonsubstituted or substituted) phenoxy picolinic acids, process of preparing the same, and agricultural/horticultural germicides containing the same
  申请人：Kureha Kagaku Kabushiki Kaisha

  公开号：US06200933B1

  公开（公告）日：2001-03-13

  An agricultural or horticultural fungicide containing 6-(unsubstituted or substituted) phenoxy picolinic acid represented by the general formula (I), as an effective ingredient. wherein R is a halogen atom, a C1 to C4 alkyl group, a C1 to C4 haloalkyl group, a C1 to C4 alkoxy group, a C1 to C4 haloalkoxy group, a C1 to C4 alkylthio group, a C1 to C4 alkylamino group, a di(C1 to C4 alkyl)amino group or a C7 to C8 aralkyl(C1 to C4 alkyl)amino group; n2 is an integer of 0 to 3; Y is a C1 to C4 alkyl group, a C1 to C4 haloalkyl group, a C1 to C4 alkoxy group, a C1 to C4 haloalkoxy group, a C1 to C4 alkylthio group, a C1 to C4 haloalkylthio group or a halogen atom; and m is an integer of 0 to 5, and when m and n2 are not less than 2, Rs and Ys may be the same or different, respectively. The compound is useful as an effective ingredient of agricultural or horticultural fungicides.

  一种包含6-(未取代或取代)苯氧基吡啶甲酸的农业或园艺杀菌剂，其通式为(I)，作为有效成分。其中R是卤素原子，C1至C4烷基，C1至C4卤代烷基，C1至C4烷氧基，C1至C4卤代烷氧基，C1至C4烷硫基，C1至C4烷基胺基，二(C1至C4烷基)胺基或C7至C8芳基(C1至C4烷基)胺基；n2为0至3的整数；Y为C1至C4烷基，C1至C4卤代烷基，C1至C4烷氧基，C1至C4卤代烷氧基，C1至C4烷硫基，C1至C4卤代烷硫基或卤素原子；m为0至5的整数，当m和n2均不小于2时，Rs和Ys可以分别相同或不同。该化合物可作为农业或园艺杀菌剂的有效成分。
• Catalytic Enantioselective Synthesis and Switchable Chiroptical Property of Inherently Chiral Macrocycles
  作者：Shuo Tong、Jiang-Tao Li、Dong-Dong Liang、Yan-E Zhang、Qi-Yun Feng、Xin Zhang、Jieping Zhu、Mei-Xiang Wang

  DOI：10.1021/jacs.0c05369

  日期：2020.8.26

  We report herein a strategy to construct enantiopure inherently chiral macrocycles, ABCD-type heteracalix[4]aromatics, through a catalytic enantioselective intramolecular C-N bond forming reaction. A chiral ligand-palladium complex was found to efficiently induce the inherent chirality of molecules during macrocyclization process with ee values up to >99%. The resulting ABCD-type heteracalix[4]aromatics

  我们在此报告了一种通过催化对映选择性分子内 CN 键形成反应构建对映纯的固有手性大环、ABCD 型杂杯 [4] 芳烃的策略。发现手性配体-钯配合物在大环化过程中有效地诱导分子的固有手性，ee 值高达 >99%。由此产生的 ABCD 型杂杯 [4] 芳烃显示出优异的和 pH 触发的可切换电子圆二色性和圆偏振发光特性。