二癸胺 | 1120-49-6

• 物质功能分类: 表面活性剂 - 工业表面活性剂
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 二癸胺
• 中文别名: N-癸基-1-癸胺；二正癸胺；二正癸胺,N-癸基-1-癸胺；双十烷基胺
• 英文名称: didecylamine
• 英文别名: di(n-decyl)amine；N,N-didecylamine；N,N-di-n-decylamine；N-decyldecan-1-amine；bis-decylamine
• CAS: 1120-49-6
• 化学式: C₂₀H₄₃N
• mdl: MFCD00048396
• 分子量: 297.568
• InChiKey: GMTCPFCMAHMEMT-UHFFFAOYSA-N

物化性质

• 熔点：
  38-40 °C(lit.)
• 沸点：
  179-180 °C2 mm Hg(lit.)
• 密度：
  0.7963 (estimate)
• 闪点：
  >230 °F
• 溶解度：
  Chloroform (Slightly), Ethyl Acetate (Slightly) , Hexanes (Slightly)
• 保留指数：
  2142
• 稳定性/保质期：

  在常温常压下保持稳定，避免与氧化物接触。使用时请穿戴防护服装。

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  21
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  8
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2921199090
• 包装等级：
  II
• 危险类别：
  8
• 危险品运输编号：
  2735
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  请将容器密封保存，并存放在阴凉、干燥处。

SDS

Didecylamine Revision number: 6
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Didecylamine

Revision number: 6

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Didecylamine
Percent: >95.0%(GC)(T)
CAS Number: 1120-49-6
Chemical Formula: C20H43N

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Didecylamine

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Section 4. FIRST AID MEASURES
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store under inert gas.
Store away from incompatible materials such as oxidizing agents.
Air-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Crystal- Lump
Form:
Didecylamine

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Colour: White - Almost white
Odour: No data available
pH: No data available
Melting point/freezing point:32°C (Freezing point)
Boiling point/range: No data available
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: No data available
Solubility(ies):
[Water] No data available
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Stable under proper conditions.
Chemical stability:
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
No data available
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed
Didecylamine

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途：有机合成。

反应信息

• 作为反应物：
  描述：

  二癸胺 在 Co₂Rh₂/C 作用下， 以 甲苯 为溶剂， 180.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 以76%的产率得到三癸胺
  参考文献：
  名称：

  使用Co-Rh异双金属纳米催化剂将伯胺转化为对称的仲胺和叔胺

  摘要：

  通过使用异质双金属Co 2 Rh 2 / C作为催化剂（摩尔比Co：Rh = 2：2）进行脱氨基均偶联，可以有效地从胺和仲胺中获得对称的叔胺。苯胺与对称叔胺的反应产生不对称仲苯胺。Co 2 Rh 2 / C催化剂对多种胺类均表现出非常高的催化活性，可以方便地循环使用十次而不会产生明显的浸出。

  DOI：

  10.1002/adsc.201701522
• 作为产物：
  描述：

  癸腈 在 10% rhodium on carbon 、 氢气 作用下， 以 环己烷 为溶剂， 以68%的产率得到二癸胺
  参考文献：
  名称：

  流动反应条件下腈高选择性加氢转化为叔胺、仲胺和伯胺

  摘要：

  三选一还不错：通过在流动条件下氢化腈以中等至定量的收率合成各种叔胺、仲胺和伯胺。该方法能够通过使用商业 Pd/C 或 Rh/C 催化剂和溶剂从一种腈选择性合成三种不同类型的胺。填充催化剂的药筒连续使用至少 72 小时。

  DOI：

  10.1002/cssc.202102138

文献信息

• Compositions for Targeted Delivery of siRNA
  申请人：Rozema David B.

  公开号：US20110207799A1

  公开（公告）日：2011-08-25

  The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

  本发明涉及用于靶向递送RNA干扰（RNAi）多核苷酸至体内肝细胞的组合物。靶向RNAi多核苷酸与共靶向递送聚合物一起给予。递送聚合物提供膜穿透功能，用于将RNAi多核苷酸从细胞外运送到细胞内。可逆修饰为递送聚合物提供生理响应性。
• [EN] TRIAMINOCYCLOPROPENIUM SALTS<br/>[FR] SELS DE TRIAMINOCYCLOPROPÉNIUM
  申请人：CURNOW OWEN JOHN

  公开号：WO2012169909A1

  公开（公告）日：2012-12-13

  Disclosed are salts comprising triaminocyclopropenium cations and various anions, and ionic liquids comprising the salts. Also disclosed are intermediates and methods of preparing the salts. The ionic liquids are useful as, for example, solvents and electrolytes, and for gas storage.

  揭示了包含三氨基环丙烯阳离子和各种阴离子的盐，以及包含这些盐的离子液体。还揭示了制备这些盐的中间体和方法。这些离子液体可用作溶剂和电解质，例如用于气体储存。
• Simple RuCl ₃ ‐catalyzed <i>N</i> ‐Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol
  作者：Naina Sarki、Vishakha Goyal、Nitin Kumar Tyagi、Puttaswamy、Anand Narani、Anjan Ray、Kishore Natte

  DOI：10.1002/cctc.202001937

  日期：2021.4.9

  readily available feedstock chemicals, highlighting synthetic value of this advanced N‐methylation reaction. Using this platform, we also attempted tandem reactions with selected nitroarenes to convert them into corresponding N‐methylated amines using MeOH under H2‐free conditions including transfer hydrogenation of nitroarenes‐to‐anilines and prepared drug molecules (e. g., benzocaine and butamben) as well

  甲醇是潜在的氢源和C 1合成子，在化学合成和能源技术中都有有趣的应用。在有机合成中有效利用这种简单的醇具有至关重要的意义，并引起了科学兴趣。本文中，我们报道了一种清洁且具有成本竞争力的方法，该方法使用甲醇作为C 1合成子和H 2源，通过使用相对便宜的RuCl 3 .xH 2 O作为无配体催化剂，对胺进行选择性N-甲基化。这种易于获得的催化剂可耐受各种包含缺电子基团和供电子基团的胺，并使它们转化为相应的N甲基化产品，产率中等至优异。此外，很少有市售的药剂（例如文拉法辛和丙咪嗪）是通过后期功能化从容易获得的原料化学品中成功合成的，从而突出了这种先进的N-甲基化反应的合成价值。在该平台上，我们还尝试与选定的硝基芳烃进行串联反应，以在H 2下使用MeOH将它们转化为相应的N甲基化胺。无条件的条件包括硝基芳烃到苯胺的转移氢化以及制备的药物分子（例如苯佐卡因和丁苯本）以及关键的医药中间体。我们进一步使
• Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents
  作者：Rafael F. A. Gomes、Vera M. S. Isca、Késsia Andrade、Patrícia Rijo、Carlos A. M. Afonso

  DOI：10.1002/cmdc.202100369

  日期：2021.9.16

  naturally occurring cyclopentenones, such as palmenones and nigrosporiones, exhibit antimicrobial activity. Herein we describe the antimicrobial activity of cyclopentenones and derivatives that can be easily accessed from biomass derivatives furfural and 5-hydroxymethylfurfural. Upon screening a range of functionalized trans-diamino-cyclopentenones (DCPs) and δ-lactone-fused cyclopentenones (LCPs), an oxime

  几种天然存在的环戊烯酮，例如棕榈酮和黑孢子酮，表现出抗菌活性。在此，我们描述了环戊烯酮及其衍生物的抗菌活性，这些活性可以从生物质衍生物糠醛和 5-羟甲基糠醛中轻松获得。在筛选一系列功能化反式二氨基环戊烯酮 (DCP) 和 δ-内酯稠合环戊烯酮 (LCP) 后，发现 DCP 的肟醚衍生物对革兰氏阳性菌（包括甲氧西林等耐药菌株）表现出显着的抗菌活性耐药金黄色葡萄球菌(MRSA) 和耐万古霉素粪肠球菌(VRE) 菌株。
• Synthesis and physical properties of tris(dialkylamino)cyclopropenium dicyanamide ionic liquids
  作者：Owen J. Curnow、Matthew I. J. Polson、Kelvin J. Walst、Ruhamah Yunis

  DOI：10.1039/c8ra05558k

  日期：——

  The synthesis and properties of 16 tris(dialkylamino)cyclopropenium (TDAC) cations with the dicyanamide (DCA) anion, [N(CN)2]−, are described. D3h- and C3h-symmetric cations ([C3(NR2)3]DCA (R = Me, Et, Pr, Bu, Pent, Hex, Dec) and [C3(NRMe)3]DCA (R = Bu, St), respectively) were synthesised by reaction of C3Cl5H with the corresponding amine. Reaction of the alkoxydiaminocyclopropenium salt [C3(NEt2)2(OMe)]+

  描述了 16 个三（二烷基氨基）环丙烯 (TDAC) 阳离子与双氰胺 (DCA) 阴离子 [N(CN) 2 ] -的合成和性质。D 3h - 和C 3h -对称阳离子（[C 3 (NR 2 ) 3 ]DCA (R = Me, Et, Pr, Bu, Pent, Hex, Dec) 和 [C 3 (NRMe) 3 ]DCA (R = Bu、St)、分别)通过C 3 Cl 5 H与相应的胺反应合成。烷氧基二氨基环丙烯盐[C 3 (NEt 2 ) 2 (OMe)]的反应 +与胺产生一系列C 2v对称盐 [C 3 (NEt 2 ) 2 (NR 2 )]DCA (R = Me, Bu, Hex) 和两种C s对称盐和 [C 3 (NEt 2 ) 2 (NRMe)]DCA (R = Me, Bu)。类似地，[C 3 (NMe 2 ) 2 (OMe)] +用于制备C s -对称盐 [C 3 (NMe 2

表征谱图