7-[2-(N,N-diethylamino)ethoxy]-4-methylchromen-2-one | 24416-77-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[2-(N,N-diethylamino)ethoxy]-4-methylchromen-2-one
• 英文别名: 7-(2-diethylamino-ethoxy)-4-methyl-coumarin；7-(2-Diaethylamino-aethoxy)-4-methyl-cumarin；2H-1-Benzopyran-2-one, 7-(2-(diethylamino)ethoxy)-4-methyl-；7-[2-(diethylamino)ethoxy]-4-methylchromen-2-one
• CAS: 24416-77-1
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.348
• InChiKey: AXFDKDUQMWOLKG-UHFFFAOYSA-N

物化性质

• 熔点：
  89 °C(Solv: chloroform (67-66-3))
• 沸点：
  419.5±45.0 °C(Predicted)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-[2-(N,N-diethylamino)ethoxy]-4-methylchromen-2-one 在 盐酸 作用下， 以 乙醇 为溶剂， 以92%的产率得到7-[2-(N,N-diethylamino)ethoxy]-4-methylchromen-2-one hydrochloride
  参考文献：
  名称：

  Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin

  摘要：

  A series of novel O-aminoalkyl substituted 7-hydroxycoumarins were synthesized and evaluated for antibacterial and anticancer toxicity. Two different synthetic procedures, conventional and microwave assisted were used, and the structures of the compounds were confirmed by IR. H-1, C-13 NMR and MAS spectroscopic data. The molecular and crystal structures of 8-acetyl-7-(2-(1-morpholino)ethoxy) 4-methylchromen-2-one in solid state were analyzed by single crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P2(1)/c. The main driving forces for the supramolecular structure are the C-H center dot center dot center dot O hydrogen bonds and the it pi...pi it intermolecular interactions. The most active compounds are those, where the O-aminoalkyl substituent has N,N-diethylamino part, and acetyl group is at C6 or at C8 atoms. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.006
• 作为产物：
  描述：

  羟甲香豆素 、 N,N-二乙基氯乙胺 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 0.17h， 以57%的产率得到7-[2-(N,N-diethylamino)ethoxy]-4-methylchromen-2-one
  参考文献：
  名称：

  Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin

  摘要：

  A series of novel O-aminoalkyl substituted 7-hydroxycoumarins were synthesized and evaluated for antibacterial and anticancer toxicity. Two different synthetic procedures, conventional and microwave assisted were used, and the structures of the compounds were confirmed by IR. H-1, C-13 NMR and MAS spectroscopic data. The molecular and crystal structures of 8-acetyl-7-(2-(1-morpholino)ethoxy) 4-methylchromen-2-one in solid state were analyzed by single crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P2(1)/c. The main driving forces for the supramolecular structure are the C-H center dot center dot center dot O hydrogen bonds and the it pi...pi it intermolecular interactions. The most active compounds are those, where the O-aminoalkyl substituent has N,N-diethylamino part, and acetyl group is at C6 or at C8 atoms. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.006

文献信息

• Massarani, Farmaco, Edizione Scientifica, 1957, vol. 12, p. 691,693
  作者：Massarani

  DOI：——

  日期：——
• Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin
  作者：Joanna Trykowska Konc、Elżbieta Hejchman、Hanna Kruszewska、Irena Wolska、Dorota Maciejewska

  DOI：10.1016/j.ejmech.2011.03.006

  日期：2011.6

  A series of novel O-aminoalkyl substituted 7-hydroxycoumarins were synthesized and evaluated for antibacterial and anticancer toxicity. Two different synthetic procedures, conventional and microwave assisted were used, and the structures of the compounds were confirmed by IR. H-1, C-13 NMR and MAS spectroscopic data. The molecular and crystal structures of 8-acetyl-7-(2-(1-morpholino)ethoxy) 4-methylchromen-2-one in solid state were analyzed by single crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P2(1)/c. The main driving forces for the supramolecular structure are the C-H center dot center dot center dot O hydrogen bonds and the it pi...pi it intermolecular interactions. The most active compounds are those, where the O-aminoalkyl substituent has N,N-diethylamino part, and acetyl group is at C6 or at C8 atoms. (C) 2011 Elsevier Masson SAS. All rights reserved.