decyloxyacetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: decyloxyacetic acid
• 英文别名: 2-(decyloxy)acetic acid；2-Decoxyacetic acid
• 化学式: C₁₂H₂₄O₃
• 分子量: 216.321
• InChiKey: WZROSPHFTWMIGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  decyloxyacetic acid 在 氯化亚砜 作用下， 反应 3.0h， 以10.5 g的产率得到1-氯甲氧基癸烷
  参考文献：
  名称：

  도네페질 미리스틸옥시메틸에테르 또는 이의 약제학적으로 허용가능한 염

  摘要：

  本发明涉及一种新型的多奈哌齐棕榈酰氧甲基醚（Donepezil myristyloxymethyl ether）或其药学上可接受的盐，并涉及包含其为主要成分的缓释药物制剂。本发明的多奈哌齐棕榈酰氧甲基醚通过将棕榈酰氧甲基醚基引入多奈哌齐中，在体内给药时减少多奈哌齐这一活性成分的初始释放，从而降低药物毒性等副作用的风险，并且在体内可以持续稳定地释放多奈哌齐，以提高治疗失智症患者的药物疗效。

  公开号：

  KR101980534B1
• 作为产物：
  描述：

  sodium 2-(decyloxy)acetate 在 盐酸 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 1.0h， 以33.1 g的产率得到decyloxyacetic acid
  参考文献：
  名称：

  도네페질 미리스틸옥시메틸에테르 또는 이의 약제학적으로 허용가능한 염

  摘要：

  本发明涉及一种新型的多奈哌齐棕榈酰氧甲基醚（Donepezil myristyloxymethyl ether）或其药学上可接受的盐，并涉及包含其为主要成分的缓释药物制剂。本发明的多奈哌齐棕榈酰氧甲基醚通过将棕榈酰氧甲基醚基引入多奈哌齐中，在体内给药时减少多奈哌齐这一活性成分的初始释放，从而降低药物毒性等副作用的风险，并且在体内可以持续稳定地释放多奈哌齐，以提高治疗失智症患者的药物疗效。

  公开号：

  KR101980534B1

文献信息

• Macrocyclic oxalactones ( dioxacycloalkan-ones ) and their use as perfumes
  申请人：PFW AROMA CHEMICALS B.V.

  公开号：EP1099698A1

  公开（公告）日：2001-05-16

  The invention relates to a novel class of macrocyclic oxalactones which are highly useful for use as perfumes. The compounds according to the invention have a very desirable fresh and floral musk odor in combination with other advantageous properties, such as stability, and substantivity.

  该发明涉及一种新型的大环羧酸内酯类化合物，非常适用于作为香水使用。根据该发明的化合物具有非常理想的清新花香麝香气味，结合其他有利特性，如稳定性和持久性。
• Rubber compositions having improved processability and improved rubber-vulcanisate properties
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0487809A1

  公开（公告）日：1992-06-03

  Alkyloxyalkanoic acids, salts or esters having the formula         R¹-O-(CR³R⁴)x CO₂R² where R¹ represents an alkyl or alkenyl group, or a hydroxy- or alkoxy- substituted alkyl or alkenyl group, said group containing (apart from the alkoxy carbon atoms in an alkoxy-substituted alkyl or alkenyl group) from 1 to 22 carbon atoms, R² represents hydrogen, a metallic or other cationic group, or an esterifying group, each of R³ and R⁴ represents independently hydrogen or an alkyl group, and x has a value of from 1 to 10, act as agents useful for modifying rubber properties. Compared with conventional processing aids, they improve the processing characteristics of unvulcanised rubber compositions and can have beneficial effect on the physical properties of vulcanisates obtained by the vulcanisation of such compositions.

  烷氧基烷酸、盐或酯，其式如下 R¹-O-(CR³R⁴)x CO₂R² 其中 R¹ 代表烷基或烯基，或羟基或烷氧基取代的烷基或烯基，所述基团含有（除烷氧基取代的烷基或烯基的烷氧基碳原子外）1 至 22 个碳原子；R² 代表氢、金属或其他阳离子基团或酯化基团；R³ 和 R⁴ 各自独立地代表氢或烷基；x 的值为 1 至 10。与传统加工助剂相比，它们可改善未硫化橡胶组合物的加工特性，并对通过硫化此类组合物获得的硫化胶的物理性质产生有益影响。
• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：JNC Corporation

  公开号：EP3275973A1

  公开（公告）日：2018-01-31

  Subject The subject is to provide a liquid crystal composition that includes a polymerizable compound (or polymer) and a polar compound, where the homeotropic alignment of liquid crystal molecules can be achieved by the action of these compounds, and a liquid crystal display device including this composition. This composition satisfies at least one of characteristics such as a high maximum temperature, a low minimum temperature, a small viscosity, a suitable optical anisotropy, a large positive dielectric anisotropy, a large specific resistance, a high stability to ultraviolet light or heat or a large elastic constant, or is suitably balanced regarding at least two of the characteristics. The means concerns a nematic liquid crystal composition that has positive dielectric anisotropy and that includes a polymerizable compound as an first additive and a polar compound as a second additive, and the composition may include a specific liquid crystal compound having a large positive dielectric anisotropy and a specific liquid crystal compound having a high maximum temperature or a small viscosity, and concerns a liquid crystal display device including the composition.

  主题 本课题旨在提供一种液晶组合物，其中包括一种可聚合化合物（或聚合物）和一种极性化合物，通过这些化合物的作用可实现液晶分子的各向同性排列，并提供一种包括这种组合物的液晶显示装置。这种组合物至少满足以下一种特性，如最高温度高、最低温度低、粘度小、光学各向异性合适、正介电各向异性大、比电阻大、对紫外线或热的稳定性高或弹性常数大，或至少在其中两种特性方面适当平衡。 该手段涉及一种具有正介电常数的向列液晶组合物，该组合物包括作为第一添加剂的可聚合化合物和作为第二添加剂的极性化合物，该组合物可包括具有较大正介电常数的特定液晶化合物和具有较高最高温度或较小粘度的特定液晶化合物，还涉及一种包括该组合物的液晶显示设备。
• Fatty acid analogs and their use in the treatment of conditions related to metabolic syndrome
  申请人：Epitracker, Inc.

  公开号：US10792266B2

  公开（公告）日：2020-10-06

  Compositions comprising fatty acid analogs are provided for treating metabolic syndrome, anemia, cancer, cardiovascular disease, diabetes, dyslipidemia, hypertension, inflammation, insulin resistance, prediabetes, fatty liver disease, steatohepatitis, iron overload, neurodegenerative diseases, including Alzheimer's disease and other forms of dementia, and other related conditions. Methods for the diagnosis and monitoring of metabolic syndrome and other conditions are also provided.

  提供了包含脂肪酸类似物的组合物，用于治疗代谢综合征、贫血、癌症、心血管疾病、糖尿病、血脂异常、高血压、炎症、胰岛素抵抗、糖尿病前期、脂肪肝、脂肪性肝炎、铁超载、神经退行性疾病（包括阿尔茨海默病和其他形式的痴呆症）以及其他相关疾病。还提供了诊断和监测代谢综合征和其他疾病的方法。
• SKIN CLEANSING COMPOSITION
  申请人：Kao Corporation

  公开号：EP2821054B1

  公开（公告）日：2018-01-31