Crotonsaeuremethylester-γ-carbonsaeure

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Crotonsaeuremethylester-γ-carbonsaeure
• 英文别名: 5-Methoxy-5-oxopent-3-enoic acid
• 化学式: C₆H₈O₄
• 分子量: 144.127
• InChiKey: SBNNUHHLEQVQSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-甲氧基色胺 、 Crotonsaeuremethylester-γ-carbonsaeure 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以65%的产率得到
  参考文献：
  名称：

  转移的Bischler–Napieralski级联反应合成咔唑

  摘要：

  似乎微不足道的Bischler-Napieralski反应中发生无法预料的扭曲，导致选择性生成了意外的咔唑产物。事实证明，该反应是一般性的，可从易于获得的底物中获得各种不同取代的咔唑。取代基的明智变化揭示了一个复杂的级联机制，该机制包括不少于10个基本步骤，可以以多种方式转向各种其他咔唑衍生物。

  DOI：

  10.1021/acs.orglett.1c00785
• 作为产物：
  描述：

  巴豆酸甲酯 、 二氧化碳 在 sodium phenoxide 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 Crotonsaeuremethylester-γ-carbonsaeure
  参考文献：
  名称：

  Bottaccio,G.; Chiusoli,G.P., Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, p. 1016

  摘要：

  DOI：

文献信息

• [EN] BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS<br/>[FR] ACIDES BÊTA-TÉTRAZOLYLE-PROPIONIQUES UTILES EN TANT QU'INHIBITEURS DES MÉTALLO-BÊTA-LACTAMASES
  申请人：MERCK SHARP & DOHME

  公开号：WO2015171474A1

  公开（公告）日：2015-11-12

  The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

  本发明涉及公式I的化合物，这些化合物是金属β-内酰胺酶抑制剂，以及这些化合物的合成和与β-内酰胺类抗生素一起使用以克服抗性的用途。
• BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3139918A1

  公开（公告）日：2017-03-15
• WATER DISPERSIBLE, SELF-CROSSLINKABLE PREPOLYMER COMPOSITON
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US20140378607A1

  公开（公告）日：2014-12-25

  The present invention provides an economical route to environmentally friendly polymeric coatings with a high content of raw materials from renewable resources. These polymeric coatings offer performance characteristics that are competitive with conventional coating systems. The unique polymers on which this invention is based are copolymers of triglyceride oils, such as soybean oil, linseed oil, or another natural oil, with a vinyl compound, such as an acrylate or methacrylate, or a vinyl aromatic monomer. The present invention more specifically discloses a water dispersible, self-crosslinkable prepolymer composition which is comprised of a triglyceride oil having appended thereto (1) hydroxyl groups, (2) epoxy groups, (3) moieties which contain at least one aldehyde group or at least one ketone group, and (4) moieties which contain at least one vinyl and/or substituted vinyl group. In one embodiment of this invention the moiety which contains at least one vinyl group is derived from maleic anhydride.
• WATER DISPERSIBLE, SELF-CROSSLINKABLE PREPOLYMER COMPOSITION
  申请人：Pajerski Anthony D.

  公开号：US20170145245A1

  公开（公告）日：2017-05-25

  The present invention provides an economical route to environmentally friendly polymeric coatings with a high content of raw materials from renewable resources. These polymeric coatings offer performance characteristics that are competitive with conventional coating systems. The unique polymers on which this invention is based are copolymers of triglyceride oils, such as soybean oil, linseed oil, or another natural oil, with a vinyl compound, such as an acrylate or methacrylate, or a vinyl aromatic monomer. The present invention more specifically discloses a water dispersible, self-crosslinkable prepolymer composition which is comprised of a triglyceride oil having appended thereto (1) hydroxyl groups, (2) epoxy groups, (3) moieties which contain at least one aldehyde group or at least one ketone group, and (4) moieties which contain at least one vinyl and/or substituted vinyl group. In one embodiment of this invention the moiety which contains at least one vinyl group is derived from maleic anhydride.
• US9567311B2
  申请人：——

  公开号：US9567311B2

  公开（公告）日：2017-02-14