(2S)-2,5-bis(hexadecanoylamino)pentanoic acid | 112207-92-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2,5-bis(hexadecanoylamino)pentanoic acid
• CAS: 112207-92-8
• 化学式: C₃₇H₇₂N₂O₄
• 分子量: 608.99
• InChiKey: FTRXZPBVJYVTBD-UMSFTDKQSA-N

物化性质

• 沸点：
  766.1±55.0 °C(predicted)
• 密度：
  0.942±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  13.9
• 重原子数：
  43
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S)-2,5-bis(hexadecanoylamino)pentanoic acid 在 lithium hydroxide 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 反应 22.0h， 生成 4-[2-[2-[2-[[(2S)-2,5-bis(hexadecanoylamino)pentanoyl]amino]ethoxy]ethoxy]ethoxy]pyridine-2,6-dicarboxylic acid
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k
• 作为产物：
  描述：

  L-鸟氨酸盐酸盐 在 4-二甲氨基吡啶 、 lithium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 反应 45.0h， 生成 (2S)-2,5-bis(hexadecanoylamino)pentanoic acid
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k

文献信息

• L-GLUTAMIC ACID-PRODUCING BACTERIUM AND METHOD FOR PRODUCTION OF L-GLUTAMIC ACID
  申请人：Ajinomoto Co., Inc.

  公开号：EP1930409A1

  公开（公告）日：2008-06-11

  A method for producing L-glutamic acid, comprising culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium or cells.

  一种生产 L-谷氨酸的方法，包括在培养基中培养一种具有 L-谷氨酸生产能力的伞形菌，该伞形菌已被改造，从而增强了 fasR 基因的表达，在培养基或细胞中产生和积累 L-谷氨酸，并从培养基或细胞中收集 L-谷氨酸。
• PROCESS FOR PRODUCING L-LYSINE AND L-GLUTAMIC ACID BY FERMENTATION
  申请人：Ajinomoto Co., Inc.

  公开号：EP0780477B1

  公开（公告）日：2003-04-09
• Methods for producing L-lysine and L-glutamic acid by fermentation
  申请人：Ajinomoto Co., Inc.

  公开号：EP1293560B1

  公开（公告）日：2007-11-14
• L-Glutamic Acid Producing Bacterium and a Method for Production of L-Glutamic Acid
  申请人：Hirano Seiko

  公开号：US20090258402A1

  公开（公告）日：2009-10-15

  A method for producing L-glutamic acid by culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium or cells.
• US3971701A
  申请人：——

  公开号：US3971701A

  公开（公告）日：1976-07-27