L-ornithine copper complex

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-ornithine copper complex
• 英文别名: [Cu(lysine(-1H))2]；copper;(2S)-2,5-diaminopentanoate
• 化学式: C₁₀H₂₂CuN₄O₄
• 分子量: 325.855
• InChiKey: CRJSDECKGYKROL-SCGRZTRASA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  184
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  L-ornithine copper complex 在 potassium cyanate 作用下， 生成 L-citrulline copper complex
  参考文献：
  名称：

  [EN] IMPROVED METHOD OF SYNTHESIS AND PURIFICATION OF CITRULLINE
  [FR] PROCÉDÉ AMÉLIORÉ DE SYNTHÈSE ET DE PURIFICATION DE LA CITRULLINE

  摘要：

  本发明提供了一种从鸟氨酸的过渡金属配合物中使用氰酸盐对鸟氨酸的末端氨基基团进行衍生化来合成精氨酸的方法。本发明还提供了改进的精氨酸纯化方法，通过再沉淀精氨酸铜配合物，通过硫化物沉淀去除络合金属，活性炭吸附和反溶剂结晶的步骤来制备氨基酸。

  公开号：

  WO2020247853A1
• 作为产物：
  描述：

  L-鸟氨酸盐酸盐 生成 L-ornithine copper complex
  参考文献：
  名称：

  RANGANATHAN, DARSHAN;RATHI, RAMESH, J. ORG. CHEM., 55,(1990) N, C. 2351-2354

  摘要：

  DOI：

文献信息

• Coordination interactions of alkyl-substituted 2,2′-dipyrrolylmethene derivatives with copper(II) aminoacid complexes
  作者：E. V. Rumyantsev、I. E. Kolpakov、Yu. S. Marfin、E. V. Antina

  DOI：10.1134/s1070363209030232

  日期：2009.3

  Using the method of electron spectroscopy we showed that reaction of alkyl-substituted 2,2'-dipyrrolylmethene derivatives with copper(II) aminoacid complexes led to the formation of heteroligand complexes with two chelated metallocycles forming their coordination sphere. Formation constants of the heteroligand complexes were established and their interrelations with the structure of the aminoacid residue side group were elucidated. It was found that alongside the ability to the primary solvolytic dissociation of aminoacid complex, the main effect on the formation of combined coordination sphere of the chelate is defined by the steric factor depending on the structure of substituent in the aminoacid.
• RANGANATHAN, DARSHAN;RATHI, RAMESH, J. ORG. CHEM., 55,(1990) N, C. 2351-2354
  作者：RANGANATHAN, DARSHAN、RATHI, RAMESH

  DOI：——

  日期：——
• JPH08295613A
  申请人：——

  公开号：JPH08295613A

  公开（公告）日：1996-11-12
• IMPROVED METHOD OF SYNTHESIS AND PURIFICATION OF CITRULLINE
  申请人：Asklepion Pharmaceuticals, LLC

  公开号：US20220227702A1

  公开（公告）日：2022-07-21

  This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.
• US6127420A
  申请人：——

  公开号：US6127420A

  公开（公告）日：2000-10-03