4-[1,3-Bis(phenylmethoxy)propan-2-yloxy]-4-oxobutanoic acid | 220750-68-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[1,3-Bis(phenylmethoxy)propan-2-yloxy]-4-oxobutanoic acid
• CAS: 220750-68-5
• 化学式: C₂₁H₂₄O₆
• 分子量: 372.418
• InChiKey: CEZPAEWXDFZKIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[1,3-Bis(phenylmethoxy)propan-2-yloxy]-4-oxobutanoic acid 在 palladium dihydroxide 4-二甲氨基吡啶 、 氢气 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 Succinic acid (3S,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 2-hydroxy-1-hydroxymethyl-ethyl ester
  参考文献：
  名称：

  Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum

  摘要：

  The beta-cholestane derivatives 1a similar to c bearing a cascade-type polyol, were newly synthesized. The release of fluorescent marker 6-CF [5(6)-carboxyfluorescein] encapsulated in the modified liposomes prepared from 1 was dramatically faster than that in the conventional liposomes prepared from cholesterol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00723-9
• 作为产物：
  描述：

  丁二酸酐 、 1,3-双(苄氧基)-2-丙醇 在 吡啶 作用下， 以100%的产率得到4-[1,3-Bis(phenylmethoxy)propan-2-yloxy]-4-oxobutanoic acid
  参考文献：
  名称：

  Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum

  摘要：

  The beta-cholestane derivatives 1a similar to c bearing a cascade-type polyol, were newly synthesized. The release of fluorescent marker 6-CF [5(6)-carboxyfluorescein] encapsulated in the modified liposomes prepared from 1 was dramatically faster than that in the conventional liposomes prepared from cholesterol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00723-9

文献信息

• Prodrugs
  申请人：MEDIVIR AB

  公开号：US20030186924A1

  公开（公告）日：2003-10-02

  A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig 1

  一种治疗HBV和HIV感染的方法，包括给予化合物或公式Ig1的盐。
• Antiviral methods employing double esters of 2', 3'-dideoxy-3'-fluoroguanosine
  申请人：Zhou Xiao-Xiong

  公开号：US20060122383A1

  公开（公告）日：2006-06-08

  A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig

  一种治疗HBV和HIV感染的方法，包括给予化合物或公式Ig的盐。
• ANTIVIRAL METHODS EMPLOYING DOUBLE ESTERS OF 2', 3'-DIDEOXY-3'-FLUOROGUANOSINE
  申请人：Zhou Xiao-Xiong

  公开号：US20060058259A1

  公开（公告）日：2006-03-16

  A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig

  一种治疗乙型肝炎和人类免疫缺陷病毒感染的方法，包括给予公式Ig的化合物或盐。
• 3'-Fluorinated guanosine derivatives for the treatment or prophylaxis of HBV or retroviral infections
  申请人：MEDIVIR AB

  公开号：EP1123935A2

  公开（公告）日：2001-08-16

  A compound of the formula I wherein: nuc is the residue of a nucleoside analogue bonded through its single hydroxy group on the cyclic or acyclic saccharide moiety, R1 is hydroxy, amino or carboxy; optionally having esterified/amide bonded thereon a C4-C22 saturated or unsaturated, optionally substituted fatty acid or alcohol, or an aliphatic L-amino acid; R2 is the residue of an aliphatic L-amino acid; L1 is a trifunctional linker group; L2 is absent or a difunctional linker group; and pharmaceutically acceptable salts thereof.

  式 I 的化合物 其中 nuc 是核苷类似物的残基，通过其单个羟基键合在环状或无环状糖基上、 R1 是羟基、氨基或羧基；可选择在其上酯化/酰胺键合 C4-C22 饱和或不饱和、可选择取代的脂肪酸或醇，或脂肪族 L-氨基酸； R2 是脂肪族 L-氨基酸的残余物； L1 是三官能团连接基团； L2 不存在或为双官能团连接基团； 及其药学上可接受的盐类。
• NUCLEOSIDES ANALOGUES, SUCH AS ANTIVIRALS INCLUDING INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTASE AND THE DNA POLYMERASE OF HEPATITIS B VIRUS (HBV)
  申请人：MEDIVIR AB

  公开号：EP0988304B1

  公开（公告）日：2001-05-02