eicosa-5(Z),8(Z),11(Z),14(Z)-tetraenamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: eicosa-5(Z),8(Z),11(Z),14(Z)-tetraenamide
• 英文别名: (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenamide
• 化学式: C₂₀H₃₃NO
• 分子量: 303.488
• InChiKey: BNBSCAZCQDLUDU-CGRWFSSPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  ammonium hydroxide 、 5,8,11,14-eicosatetraenoic acid 在 N,N'-羰基二咪唑 作用下， 以 二氯甲烷 为溶剂， 生成 eicosa-5(Z),8(Z),11(Z),14(Z)-tetraenamide
  参考文献：
  名称：

  Arachidonic acid analogues as anti-inflammatory and anti-allergic agents

  摘要：

  该发明的新化合物是四唑、酰羟胺、羟甲基酮和不饱和脂肪酸的酰胺衍生物，它们是选择性抑制酶脂氧合酶和环氧合酶的药物，这些酶参与疼痛、炎症、支气管收缩和过敏反应的产生。这些化合物有益于治疗多种炎症和/或疼痛症状以及过敏反应。

  公开号：

  US04497827A1

文献信息

• External preparation
  申请人：Sansho Seiyaku Co., Ltd.

  公开号：EP0355842A2

  公开（公告）日：1990-02-28

  This invention provides an external preparation effectively preventing skin pigmentation caused by melanin production, i.e. spots or freckle, and having also superior actions on fair-skin making up, the external preparation containing unsaturated straight-­chain fatty acids or unsaturated straight-chain aliphatic alcohols or the derivatives thereof as effective ingredients.

  本发明提供了一种外用制剂，可有效防止因黑色素生成而引起的皮肤色素沉着，即色斑或雀斑，同时对白皙皮肤的妆容也有卓越功效，该外用制剂含有不饱和直链脂肪酸或不饱和直链脂肪醇或其衍生物作为有效成分。
• MULTI-LAYER PLASTIC CONTAINER FOR NON-OILY CONTENT
  申请人：Toyo Seikan Kaisha, Ltd.

  公开号：EP2123571A1

  公开（公告）日：2009-11-25

  [problem] To provide a polyethylene container which enables a non-oily viscous content such as ketchup or the like to favorably run down when the container is inverted. [Means for Solution] A polyethylene container having at least a polyethylene resin layer on the inner surface thereof, wherein the polyethylene resin layer on the inner surface of the container contains an aliphatic amide in an amount of not less than 500 ppm but less than 4000 ppm.

  [问题]提供一种聚乙烯容器，当容器倒置时，非油性粘性内容物（如番茄酱或类似物）可顺势流下。 [解决方法]一种聚乙烯容器，其内表面至少有一层聚乙烯树脂，其中容器内表面的聚乙烯树脂层含有脂肪族酰胺，其含量不低于 500 ppm 但低于 4000 ppm。
• Polylactic acid resin composition and resin molded article thereof
  申请人：Dai-Ichi Kogyo Seiyaku Co., Ltd.

  公开号：EP2604654A2

  公开（公告）日：2013-06-19

  Provided are a polylactic acid resin composition excellent in impact resistance, migration resistance, and heat resistance, and excellent in productivity at the time of the mold forming thereof, and a resin molded article thereof. The polylactic acid resin composition includes a polylactic acid; a reaction product of at least one of a polyol and a polyol dehydration condensate, an alkylene oxide mainly formed of ethylene oxide, and a fatty acid having 12 to 24 carbon atoms; and a fatty acid amide.

  本发明提供了一种抗冲击性、抗迁移性和耐热性极佳且在模具成型时生产效率极高的聚乳酸树脂组合物及其树脂成型品。聚乳酸树脂组合物包括聚乳酸；多元醇和多元醇脱水缩合物、主要由环氧乙烷形成的环氧烷烃和具有 12 至 24 个碳原子的脂肪酸中至少一种的反应产物；以及脂肪酸酰胺。
• THERMOPLASTIC ELASTOMER COMPOSITION
  申请人：Sumitomo Chemical Company, Ltd

  公开号：EP3404064A1

  公开（公告）日：2018-11-21

  A thermoplastic elastomer composition comprising the following components (A), (B), (C) and (D), wherein the weight ratio of the component (C) to the component (D) is 0.1 or more and less than 2. Component (A): an ethylene random copolymer comprising a monomer unit derived from ethylene in amount of 50% by weight or more and 90% by weight or less when the total amount of the ethylene random copolymer is 100% by weight and a monomer unit derived from at least one monomer selected from the group consisting of α-olefins having a number of carbon atoms of 3 or more and 10 or less, Component (B): a polymer comprising over 50% by weight and 100% by weight or less of a monomer unit derived from propylene when the total amount of the polymer is 100% by weight, Component (C): a copolymer comprising an ethylene polymerization block and an ethylene-α-olefin copolymerization block. Component (D): an ethylene polymer comprising over 90% by weight and 100% by weight or less of a monomer unit derived from ethylene when the total amount of the ethylene polymer is 100% by weight.

  一种热塑性弹性体组合物，包括 以下组分(A)、(B)、(C)和(D) 其中组分（C）与组分（D）的重量比为 0.1 或以上，小于 2。 组分(A)：乙烯无规共聚物，当乙烯无规共聚物的总重量为 100%（重量比）时，该乙烯无规共聚物包含 50%（重量比）以上和 90%（重量比）以下来自乙烯的单体单元，以及来自至少一种选自碳原子数为 3 个（含）以上和 10 个（含）以下的 α-烯烃单体的单体单元，组分(B)：当聚合物的总重量为 100%（重量比）时，该聚合物包含 50%（重量比）以上和 100%（重量比）以下来自丙烯的单体单元、 组分（C）：由乙烯聚合嵌段和乙烯-α-烯烃共聚嵌段组成的共聚物。 组分 (D)：当乙烯聚合物的总重量为 100%时，由超过 90%（按重量计）和 100%（按 重量计）或更少的乙烯衍生单体单元组成的乙烯聚合物。
• MOFEZOLAC DERIVATIVES AS MULTI-FUNCTIONS SELECTIVE COX-1 INHIBITORS
  申请人：Università degli Studi di Bari "Aldo Moro"

  公开号：EP3782990A1

  公开（公告）日：2021-02-24

  The invention relates to a new class of compounds targeting COX-1. The invention also relates to the use of some of such compounds as a tool to investigate the structure and function of the enzyme, in the treatment targeting COX-1 or detection of COX-1 in relating disorders or diseases such as cancer and neuroinflammation, in particular in neurological (e.g. autism spectrum disorders) and neurodegenerative diseases (e.g. Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), traumatic brain injury (TBI), HIV dementia and prion diseases), and in gynecological tumour (e.g. ovarian cancer), neck and head tumor, and haematological tumours (e.g. multiple myeloma) and in the detection of COX-1 in "in vitro" (cells and tissues) and in "in vivo".

  本发明涉及一类靶向 COX-1 的新型化合物。本发明还涉及将其中一些化合物用作研究酶的结构和功能的工具，用于靶向 COX-1 的治疗或检测 COX-1 在癌症和神经炎症等相关紊乱或疾病中的作用，特别是在神经系统疾病（如自闭症谱系障碍）和神经退行性疾病（如阿尔茨海默病、帕金森病、肌萎缩性侧索硬化症（ALS）、多发性硬化症（MLS））中的作用。阿尔茨海默病、帕金森病、肌萎缩性脊髓侧索硬化症（ALS）、多发性硬化症（MS）、创伤性脑损伤（TBI）、艾滋病痴呆症和朊病毒病），以及妇科肿瘤（如卵巢癌）、颈部和头部肿瘤和血液肿瘤（如多发性骨髓瘤），以及在 "体外"（细胞和组织）和 "体内 "检测 COX-1。