butyl N-(benzenesulfonyl)carbamate | 145587-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butyl N-(benzenesulfonyl)carbamate
• CAS: 145587-51-5
• 化学式: C₁₁H₁₅NO₄S
• mdl: MFCD00545436
• 分子量: 257.31
• InChiKey: UUCHVZGOLSWZJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  butyl N-(benzenesulfonyl)carbamate 、 (S)-2-Iodomethyl-4-isobutyl-5-methyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-3-one 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

  摘要：

  A challenge associated with drug design is the development of selective inhibitors of proteases (serine or cysteine) that exhibit the same primary substrate specificity, that is, show a preference for the same P-1 residue. While these proteases have similar active sites, nevertheless there are subtle differences in their S and S' subsites which can be exploited. We describe herein for the first time the use of functionalized sulfonamides as a design and diversity element which, when coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold yields potent, time-dependent inhibitors of the serine proteases human leukocyte elastase (HLE), proteinase 3 (PR 3) and cathepsin G(Cat G). Our preliminary findings suggest that (a) appending to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold recognition and diversity elements that interact with both the S and S' subsites of a target protease may result in optimal enzyme selectivity and potency and, (b) functionalized sulfonamides constitute a powerful design and diversity element with low intrinsic chemical reactivity and potentially wide applicability (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00037-2
• 作为产物：
  描述：

  苯磺酰胺 、 氯甲酸丁酯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 生成 butyl N-(benzenesulfonyl)carbamate
  参考文献：
  名称：

  Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

  摘要：

  A challenge associated with drug design is the development of selective inhibitors of proteases (serine or cysteine) that exhibit the same primary substrate specificity, that is, show a preference for the same P-1 residue. While these proteases have similar active sites, nevertheless there are subtle differences in their S and S' subsites which can be exploited. We describe herein for the first time the use of functionalized sulfonamides as a design and diversity element which, when coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold yields potent, time-dependent inhibitors of the serine proteases human leukocyte elastase (HLE), proteinase 3 (PR 3) and cathepsin G(Cat G). Our preliminary findings suggest that (a) appending to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold recognition and diversity elements that interact with both the S and S' subsites of a target protease may result in optimal enzyme selectivity and potency and, (b) functionalized sulfonamides constitute a powerful design and diversity element with low intrinsic chemical reactivity and potentially wide applicability (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00037-2

文献信息

• [EN] PHENYLALANINE DERIVATIVES AND THEIR USE AS NON-PEPTIDE GLP-1 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS PHÉNYLALANINES ET LEUR UTILISATION COMME MODULATEURS NON PEPTIDIQUES DU RÉCEPTEUR DE GLP-1
  申请人：ARGUSINA INC

  公开号：WO2011094890A1

  公开（公告）日：2011-08-11

  Provided herein are non-peptide GLP-1 receptor modulator compounds, for example, of Formula (I), pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of a metabolic disorder.

  本文提供了非肽类GLP-1受体调节剂化合物，例如，Formula (I)的化合物，包括这些化合物的药物组合物，以及其制备方法。还提供了这些化合物用于治疗代谢紊乱的方法。
• Polyolefin resin composition containing diacetal
  申请人：Horie Shouichi

  公开号：US20060100324A1

  公开（公告）日：2006-05-11

  An object of the present invention is to provide a polyolefin resin composition with excellent transparency, which is obtained by a method which is economically advantageous, and easily produces said composition, wherein said composition hardly generates white spots thought to be an insoluble part of a diacetal compound, while retaining the intact transparency imparted by the diacetal. A clarifier for polyolefin resins which comprises a combination of an acetal compound represented by the general formula (1) with a specific amount of a modifier represented by the general formula (2) or (3) is used. Thus, white spots thought to be an insoluble part of the diacetal compound can be significantly diminished.

  本发明的目的是提供一种具有优异透明度的聚烯烃树脂组合物，该组合物通过一种经济上有利的方法获得，并且易于生产所述组合物，其中所述组合物几乎不产生被认为是二缩醛化合物不溶部分的白点，同时保持二缩醛赋予的完整透明度。聚烯烃树脂澄清剂由通式（1）表示的缩醛化合物与一定量的通式（2）或（3）表示的改性剂组合而成。因此，被认为是二缩醛化合物不溶性部分的白点可以显著减少。
• Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
  作者：William C Groutas、Shu He、Rongze Kuang、Sumei Ruan、Juan Tu、Ho-Kit Chan

  DOI：10.1016/s0968-0896(01)00037-2

  日期：2001.6

  A challenge associated with drug design is the development of selective inhibitors of proteases (serine or cysteine) that exhibit the same primary substrate specificity, that is, show a preference for the same P-1 residue. While these proteases have similar active sites, nevertheless there are subtle differences in their S and S' subsites which can be exploited. We describe herein for the first time the use of functionalized sulfonamides as a design and diversity element which, when coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold yields potent, time-dependent inhibitors of the serine proteases human leukocyte elastase (HLE), proteinase 3 (PR 3) and cathepsin G(Cat G). Our preliminary findings suggest that (a) appending to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold recognition and diversity elements that interact with both the S and S' subsites of a target protease may result in optimal enzyme selectivity and potency and, (b) functionalized sulfonamides constitute a powerful design and diversity element with low intrinsic chemical reactivity and potentially wide applicability (C) 2001 Elsevier Science Ltd. All rights reserved.