2-N-{5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione}-butanedioic acid | 956239-35-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-N-{5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione}-butanedioic acid
• 英文别名: 2-[5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione]succinic acid；N-(1,2-Dicarboxyethyl) rosiglitazone；2-[5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-2,4-dioxo-1,3-thiazolidin-3-yl]butanedioic acid
• CAS: 956239-35-3
• 化学式: C₂₂H₂₃N₃O₇S
• 分子量: 473.507
• InChiKey: XZEIFCBFLCYRAH-UHFFFAOYSA-N

物化性质

• 沸点：
  678.0±65.0 °C(Predicted)
• 密度：
  1.459±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  163
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  马来酸罗格列酮 以 水 为溶剂， 反应 120.0h， 生成 2-N-{5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione}-butanedioic acid
  参考文献：
  名称：

  [EN] 2-N-(5-[[4-(2-METHYL-2-PYRIDINYLAMINO) ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE) BUTANEDIOIC ACID, METHODS OF PREPARATION AND COMPOSITIONS WITH ROSIGLITAZONE MALEATE
  [FR] ACIDE 2-N-(5-[[4-(2-METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE)BUTANEDIOIQUE, PROCEDES DE PREPARATION ET COMPOSITIONS A BASE DE MALEATE DE ROSIGLITAZONE

  摘要：

  揭示了一种化合物（I）的孤立体，以及检测它的方法和在改进的罗格列酮马来酸盐制剂中最小化它的方法。

  公开号：

  WO2007130064A1

文献信息

• PREPARATION OF ROSIGLITAZONE AND ITS SALTS
  申请人：Maddula Srinivasula Reddy

  公开号：US20070293546A1

  公开（公告）日：2007-12-20

  The present invention relates to rosiglitazone and its pharmaceutically acceptable salts free of at least one of the process related impurities, in particular the dehydro and the succinic acid impurities of rosiglitazone, wherein said impurities are present in an amount of about 05 mg to not more than about 15 mg, and processes for their preparation.

  本发明涉及罗格列酮及其药用可接受盐，不含至少一种与过程相关的杂质，特别是罗格列酮的脱氢和琥珀酸杂质，其中所述杂质的含量约为0.5毫克至不超过15毫克，并提供其制备方法。
• 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
  申请人：Dolitzky Yehudit

  公开号：US20070265312A1

  公开（公告）日：2007-11-15

  Disclosed is an isolated compound of the formula: along with methods of detecting it and of minimizing it in improved pharmaceutical compositions of rosiglitazone maleate.

  本文披露了一种化合物，其化学式为：以及检测该化合物和在改进的罗格列酮盐酸盐药物组合物中最小化该化合物的方法。
• 2-N-{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2-4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
  申请人：TEVA PHARMACEUTICAL INDUSTRIES LTD.

  公开号：EP1854794A1

  公开（公告）日：2007-11-14

  Disclosed is an isolated compound of the formula: along with methods of detecting it and of minimizing it in improved pharmaceutical compositions of rosiglitazone maleate.

  揭示了一种具有以下结构的孤立化合物，以及检测它和在改良的罗格列酮盐酸盐药物组合物中最小化它的方法。
• 2-N butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
  申请人：Dolitzky Yehudit

  公开号：US20070265313A1

  公开（公告）日：2007-11-15

  Disclosed is an isolated compound of the formula: along with methods of detecting it and of minimizing it in improved pharmaceutical compositions of rosiglitazone maleate.
• 2-N-{5-[ [4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione) butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
  申请人：Dolitzky Yehudit

  公开号：US20100081695A1

  公开（公告）日：2010-04-01

  Disclosed is an isolated compound of the formula: along with methods of detecting it and of minimizing it in improved pharmaceutical compositions of rosiglitazone maleate.