(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methoxy-4-[(2R,3R)-7-methoxy-3-methyl-5-((E)-propenyl)-2,3-dihydro-benzofuran-2-yl]-phenyl ester | 320342-79-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methoxy-4-[(2R,3R)-7-methoxy-3-methyl-5-((E)-propenyl)-2,3-dihydro-benzofuran-2-yl]-phenyl ester
• 英文别名: [2-methoxy-4-[(2R,3R)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]phenyl] (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
• CAS: 320342-79-8
• 化学式: C₃₀H₂₉F₃O₆
• 分子量: 542.552
• InChiKey: VDHWCUCFQAHBOX-SLUOECNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methoxy-4-[(2R,3R)-7-methoxy-3-methyl-5-((E)-propenyl)-2,3-dihydro-benzofuran-2-yl]-phenyl ester 在 AD-mix-α 、 甲基磺酰胺 作用下， 以 水 、 叔丁醇 为溶剂， 反应 18.0h， 以94.6%的产率得到(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 4-[(2R,3R)-5-((1S,2S)-1,2-dihydroxy-propyl)-7-methoxy-3-methyl-2,3-dihydro-benzofuran-2-yl]-2-methoxy-phenyl ester
  参考文献：
  名称：

  Stereoselective Synthesis of 8,9-Licarinediols

  摘要：

  The total synthesis of 8,9-licarinediols was selectively carried out from licarin A, previously obtained by oxidative coupling of (E)-isoeugenol. The corresponding enantiomerically pure (+)- and(-)-licarin A ester derivatives were subjected to Sharpless oxidation to yield the asymmetric C-8, C-9 dihydroxylation products, whose absolute configurations were established by means of the CD and NMR spectroscopic analyses of their Mosher ester derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00873-5
• 作为产物：
  描述：

  反式-3-(4-羟基-3-甲氧基苯基)-2-丙烯-1-醇 在 吡啶 、 双氧水 、 三乙基硼氢化锂 、 三乙胺 、 horseradish peroxidase 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 21.5h， 生成 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methoxy-4-[(2R,3R)-7-methoxy-3-methyl-5-((E)-propenyl)-2,3-dihydro-benzofuran-2-yl]-phenyl ester
  参考文献：
  名称：

  Stereoselective Synthesis of 8,9-Licarinediols

  摘要：

  The total synthesis of 8,9-licarinediols was selectively carried out from licarin A, previously obtained by oxidative coupling of (E)-isoeugenol. The corresponding enantiomerically pure (+)- and(-)-licarin A ester derivatives were subjected to Sharpless oxidation to yield the asymmetric C-8, C-9 dihydroxylation products, whose absolute configurations were established by means of the CD and NMR spectroscopic analyses of their Mosher ester derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00873-5

文献信息

• Stereoselective Synthesis of 8,9-Licarinediols
  作者：Isabele R. Nascimento、Lucia M.X. Lopes、Laurence B. Davin、Norman G. Lewis

  DOI：10.1016/s0040-4020(00)00873-5

  日期：2000.11

  The total synthesis of 8,9-licarinediols was selectively carried out from licarin A, previously obtained by oxidative coupling of (E)-isoeugenol. The corresponding enantiomerically pure (+)- and(-)-licarin A ester derivatives were subjected to Sharpless oxidation to yield the asymmetric C-8, C-9 dihydroxylation products, whose absolute configurations were established by means of the CD and NMR spectroscopic analyses of their Mosher ester derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.