salicylic acid-C10-salicylic acid | 74134-03-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: salicylic acid-C10-salicylic acid
• 英文别名: 1,10-bis-salicylic-sebacate；2-[10-(2-Carboxyphenoxy)-10-oxodecanoyl]oxybenzoic acid
• CAS: 74134-03-5
• 化学式: C₂₄H₂₆O₈
• 分子量: 442.466
• InChiKey: XVGPREYMODJRKV-UHFFFAOYSA-N

物化性质

• 熔点：
  128-129 °C
• 沸点：
  648.1±50.0 °C(Predicted)
• 密度：
  1.265±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  32
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  salicylic acid-C10-salicylic acid 在 草酰氯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 salicylic acid-C10-salicylic acid diacid chloride
  参考文献：
  名称：

  디올 화합물, 폴리카보네이트 및 이의 제조방법

  摘要：

  本发明涉及一种能够制备出具有优异机械性能、耐候性、流动性、耐热性、透明性、硬度和抗冲击性的聚碳酸酯的二醇化合物，以及由此制备的聚碳酸酯和其制备方法。

  公开号：

  KR20210029025A
• 作为产物：
  描述：

  癸二酰氯 、 水杨酸 在 吡啶 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.08h， 以91%的产率得到salicylic acid-C10-salicylic acid
  参考文献：
  名称：

  Synthesis of Polyanhydrides

  摘要：

  本发明提供了一种形成化合物的方法，其化学式为HO—C(═O)R1—X—R2—X—R1—C(═O)—O—H，其中化合物(I)可聚合以提供含有治疗活性化合物的聚合物。在本发明的化合物中，每个R1是在聚合物水解后将提供治疗活性化合物的基团；每个X独立地是酯键或酰胺键；R2是一个连接基团。

  公开号：

  US20080234235A1

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE INHIBITION OF BONE GROWTH AND RESORPTION<br/>[FR] COMPOSITIONS ET PROCEDES D'INHIBITION DE CROISSANCE ET DE RESORPTION OSSEUSE
  申请人：POLYMERIX CORP

  公开号：WO2005039489A3

  公开（公告）日：2005-06-09
• Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)
  作者：Almudena Prudencio、Robert C. Schmeltzer、Kathryn E. Uhrich

  DOI：10.1021/ma048051u

  日期：2005.8.1

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.
• Biodegradable polymers for use with implantable medical devices
  申请人：Hossainy F.A. Syed

  公开号：US20050232971A1

  公开（公告）日：2005-10-20

  The present invention relates to a stent fabricated of or coated with a composition comprising a biodegradable hydrophobic polymer containing water-labile bonds such that a device fabricated of the composition or the surface of a device coated with the requisite mechanical characteristics required of a stent and the polymer erodes from its outer surface inward.
• THERAPEUTIC DEVICES FOR PATTERNED CELL GROWTH
  申请人：Uhrich Kathryn E.

  公开号：US20100291181A1

  公开（公告）日：2010-11-18

  The invention provides therapeutic devices comprising a polymeric anti-inflammatory agent that biodegrades to release anti-inflammatory agents. The therapeutic devices are useful for repair and regeneration of a variety of injured tissues.
• US5434166A
  申请人：——

  公开号：US5434166A

  公开（公告）日：1995-07-18