N,N'-Bis(2-mercaptoethyl)butane-1,4-diamide | 116962-85-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-Bis(2-mercaptoethyl)butane-1,4-diamide
• 英文别名: N,N'-bis-(2-mercaptoethyl)-butanediamide；N,N'-bis(2-sulfanylethyl)butanediamide
• CAS: 116962-85-7
• 化学式: C₈H₁₆N₂O₂S₂
• 分子量: 236.359
• InChiKey: BTKVKOHNSVZBTJ-UHFFFAOYSA-N

物化性质

• 沸点：
  545.3±45.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  60.2
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-Bis(2-mercaptoethyl)butane-1,4-diamide 在 氢氧化钾 、 sodium hydride 作用下， 反应 4.0h， 生成 N,N'-Bis<2-<<(9-phenoxyacridin-4-yl)methyl>thio>ethyl>butane-1,4-diamide
  参考文献：
  名称：

  Topologically constrained bifunctional intercalators: DNA intercalation by a macrocyclic bisacridine

  摘要：

  DOI：

  10.1021/ja00199a047
• 作为产物：
  描述：

  丁二酰氯 、 巯基乙胺 以 二氯甲烷 为溶剂， 反应 4.0h， 以37%的产率得到N,N'-Bis(2-mercaptoethyl)butane-1,4-diamide
  参考文献：
  名称：

  Topologically constrained bifunctional intercalators: DNA intercalation by a macrocyclic bisacridine

  摘要：

  DOI：

  10.1021/ja00199a047

文献信息

• Unsymmetrical cyanine dimer compounds and their application
  申请人：Yue Stephen

  公开号：US20050074796A1

  公开（公告）日：2005-04-07

  Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.
• Use Of Aminodithiol As A Reducing Agent For Hair Perming
  申请人：Malle Gerald

  公开号：US20080138309A1

  公开（公告）日：2008-06-12

  The present invention relates to the use of aminodithiols as reducing agents for hair perming. It further relates to a hair perming method using these aminodithiols.
• UNSYMMETRICAL CYANINE DIMER COMPOUNDS AND THEIR APPLICATION
  申请人：Yue Stephen

  公开号：US20080199875A1

  公开（公告）日：2008-08-21

  Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.
• US7888136B2
  申请人：——

  公开号：US7888136B2

  公开（公告）日：2011-02-15
• US8242251B2
  申请人：——

  公开号：US8242251B2

  公开（公告）日：2012-08-14