3,3'-((4-hydroxyphenethyl)azanediyl)dipropanenitrile | 1300556-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-((4-hydroxyphenethyl)azanediyl)dipropanenitrile
• CAS: 1300556-02-8
• 化学式: C₁₄H₁₇N₃O
• 分子量: 243.308
• InChiKey: BFOMSRFDDACGRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  18.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71.05
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,3'-((4-hydroxyphenethyl)azanediyl)dipropanenitrile 在 dimethyl sulfide borane 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  A new poly(propylene imine) dendron as potential convenient building-block in the construction of multifunctional systems

  摘要：

  The synthesis of a novel third generation poly(propylene imine) dendron (PPI dendron) is described herein. The dendritic focal point was attached to a tetraethylene glycol spacer that was terminated with a Tmob-protected thiol in order to both avoid any side-reaction during functionalization of dendritic branches as well as enable convenient integration of the dendron into diverse complex systems. The protonation of the final PPI dendron at pH 4-5 is predicted to induce lysosomal degradation through the proton-sponge effect, and therefore enable cytosolic release. These features make the prepared dendron a very convenient building-block for use in the construction of larger systems, such as multifunctional drug delivery vehicles. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.01.070
• 作为产物：
  描述：

  对羟基苯乙胺 、 丙烯腈 在 溶剂黄146 作用下， 反应 24.0h， 以85%的产率得到3,3'-((4-hydroxyphenethyl)azanediyl)dipropanenitrile
  参考文献：
  名称：

  A new poly(propylene imine) dendron as potential convenient building-block in the construction of multifunctional systems

  摘要：

  The synthesis of a novel third generation poly(propylene imine) dendron (PPI dendron) is described herein. The dendritic focal point was attached to a tetraethylene glycol spacer that was terminated with a Tmob-protected thiol in order to both avoid any side-reaction during functionalization of dendritic branches as well as enable convenient integration of the dendron into diverse complex systems. The protonation of the final PPI dendron at pH 4-5 is predicted to induce lysosomal degradation through the proton-sponge effect, and therefore enable cytosolic release. These features make the prepared dendron a very convenient building-block for use in the construction of larger systems, such as multifunctional drug delivery vehicles. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.01.070