3,3'-亚甲基二[四氢-2H-1,3-恶嗪] | 63489-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 3,3'-亚甲基二[四氢-2H-1,3-恶嗪]
• 英文名称: bis(1,3-oxazinan-3-yl)methane
• 英文别名: 3,3'-methanediyl-bis-[1,3]oxazinane；bis-(dihydro-[1,3]oxazin-3-yl)-methane；Bis-(dihydro-[1,3]oxazin-3-yl)-methan；3,3'-methylenebis(tetrahydro-2H-1,3-oxazine)；3,3'-methylenebis[tetrahydro-2H-1,3-oxazine]；3-(1,3-oxazinan-3-ylmethyl)-1,3-oxazinane
• CAS: 63489-63-4
• 化学式: C₉H₁₈N₂O₂
• 分子量: 186.254
• InChiKey: GJBKLYJVZOTRSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3'-亚甲基二[四氢-2H-1,3-恶嗪] 在 亚硝酰氯 作用下， 以 乙醚 为溶剂， 以50%的产率得到3-亚硝基-1,3-恶嗪烷
  参考文献：
  名称：

  Synthesis of N-nitrosoamines by the cleavage of aminals with nitrosyl chloride

  摘要：

  DOI：

  10.1007/bf00955866
• 作为产物：
  描述：

  聚合甲醛 、 3-氨基-1-丙醇 以 苯 为溶剂， 反应 5.0h， 以97%的产率得到3,3'-亚甲基二[四氢-2H-1,3-恶嗪]
  参考文献：
  名称：

  Skeletal Diversity in Catalytic Synthesis of (1,3-Oxazacycloalk-3-ylmethyl)-Substituted Pyrroles

  摘要：

  A series of bi- and trinuclear pyrrole derivatives was prepared by the 5 mol % ZrOCl2 center dot 8H(2)O-catalyzed CH-sp(2)-aminomethylation reaction of pyrrole with bis(1,3-oxazacycloalk-3-yl)methanes. The reaction proceeds at the positions 2, 5 or 2 of pyrrole depending on the amount of aminomethylating reagents obtained from formaldehyde and alpha,omega-amino alcohols (2-aminoethan-1-ol, 3-aminopropan-1-ol, 4-aminobutan-1-ol). The aminomethylation reaction of indole with bis(1,3-oxazolidin-3-yl)methane proceeds at the position 3. In the case of carbazole, N-aminomethylation proceeds under these conditions.

  DOI：

  10.1134/s1070363219090056

文献信息

• Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
  作者：İlhami Gulçin、Malahat Abbasova、Parham Taslimi、Zübeyir Huyut、Leyla Safarova、Afsun Sujayev、Vagif Farzaliyev、Şükrü Beydemir、Saleh H. Alwasel、Claudiu T. Supuran

  DOI：10.1080/14756366.2017.1368019

  日期：2017.1.1

  synthesized by a reaction with hemiformals, which are prepared by the reaction of alcohols and formaldehyde. In this study, the inhibitory effects of these molecules were investigated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II isoenzymes (hCA I and II). Both hCA isoenzymes were significantly inhibited by the recently synthesized molecules

  含氮和硫原子的化合物可广泛用于工业，医学，生物技术和化学技术等各个领域。因此，开发了巯基苯并噻唑，巯基苯并恶唑和2-氨基噻唑的氨基甲基化和烷氧基甲基化反应。此外，巯基苯并恶唑和2-氨基噻唑的烷氧基甲基衍生物是通过与半缩醛反应合成的，半缩醛是通过醇与甲醛反应制得的。在这项研究中，研究了这些分子对乙酰胆碱酯酶（AChE），丁酰胆碱酯酶（BChE）酶和碳酸酐酶I和II同工酶（hCA I和II）的抑制作用。两种hCA同工酶均被最近合成的分子显着抑制，hCA I的Ki值在58-157 nM之间，hCA II为81-215 nM。此外，这些分子的BChE和AChE的Ki参数分别在23-88和18-78 nM范围内计算。
• Preservative compositions based on iodopropynyl- and formaldehyde donor compounds
  申请人：Air Liquide Santé (International)

  公开号：EP1413200A2

  公开（公告）日：2004-04-28

  The present invention relates to compositions having broad effectiveness against bacteria and fungi, which includes (a) an iodopropynylbutyl compound selected from iodopropynylbutyl esters, ethers, acetals, carbamates and carbonates and (b) one or more O-formals formed by the reaction of a monovalent or polyvalent C1-C10-alkyl, -aryl or -aralkyl alcohol or of a glycol or glycol ether and a formaldehyde-supplying compound. The compositions are also stable and effective in the form of liquid concentrates. The present invention also relates to the use of such compositions in industrial products and to industrial products which comprise these compositions.

  本发明涉及对细菌和真菌具有广泛功效的组合物，其中包括：(a) 选自碘丙炔丁酯、醚、乙醛、氨基甲酸酯和碳酸盐的碘丙炔丁基化合物；(b) 由一价或多价 C1-C10-烷基、-芳基或-芳烷基醇或乙二醇或乙二醇醚与甲醛供给化合物反应形成的一种或多种 O-甲醛。本发明的组合物以液体浓缩物的形式也是稳定有效的。本发明还涉及此类组合物在工业产品中的使用以及包含这些组合物的工业产品。
• Low-emission formaldehyde depot composition
  申请人：Air Liquide Santé (International)

  公开号：EP1579763A2

  公开（公告）日：2005-09-28

  The invention relates to a preservative with reduced formaldehyde and amine emission which comprises a) at least one N-formal, b) at least one emission-reducing additive which is chosen from urea, urea derivatives, amino acids, guanidine and guanidine derivatives, and c) monoethylene glycol, and to the use of the preservative in a technical product.

  本发明涉及一种可降低甲醛和胺释放量的防腐剂，它包括 a) 至少一种 N-甲醛、 b) 至少一种释放量降低添加剂，选自尿素、尿素衍生物、氨基酸、胍和胍衍生物，以及 c) 单乙二醇、 以及防腐剂在工业产品中的使用。
• Compositions based on iodopropynyl-and formaldehyde donor compounds and to their use as preservatives
  申请人：Air Liquide Sante (International)

  公开号：US20010034366A1

  公开（公告）日：2001-10-25

  Compositions having broad effectiveness against bacterial and fungi, which comprise (a) an iodopropynylbutyl compound and (b) one or more formaldehyde donor compounds, the formaldehyde donor compounds being N-formals, O-formals and/or a combination thereof. The compositions are also stable and effective in the form of liquid concentrates. The present invention also relates to the use of such compositions in industrial products and to industrial products which comprise these compositions.

  对细菌和真菌具有广泛功效的复合物，其中包括 (a) 碘丙炔丁基化合物和 (b) 一种或多种甲醛供体化合物，甲醛供体化合物为 N-甲醛、O-甲醛和/或其组合。本发明的组合物以液体浓缩物的形式使用也是稳定有效的。本发明还涉及此类组合物在工业产品中的使用以及包含这些组合物的工业产品。
• Non-formaldehyde reinforced thermoset plastic composites
  申请人：——

  公开号：US20040036056A1

  公开（公告）日：2004-02-26

  The invention relates to composition for crosslinking phenol-formaldehyde, phenol-resorcinol-formaldehyde, resorcinol-formaldehyde, tannin-formaldehyde, and similar thermosetting resins with a reactant nitroparaffin derivative, a pH adjuster, a viscosity controller, a polymerization shortstop, and water for use in Reinforced Thermal Plastic (RTP) Composite applications.

  本发明涉及苯酚-甲醛、苯酚-间苯二酚-甲醛、间苯二酚-甲醛、单宁-甲醛和类似热固性树脂与反应物硝基 石蜡衍生物、pH 值调节剂、粘度控制剂、聚合短链剂和水交联的组合物，可用于增强热塑料 （RTP）复合材料。