(RS)-5-benzylpyrazolidin-3-one | 1180009-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (RS)-5-benzylpyrazolidin-3-one
• 英文别名: 5-benzylpyrazolidin-3-one
• CAS: 1180009-65-7
• 化学式: C₁₀H₁₂N₂O
• 分子量: 176.218
• InChiKey: AMZNYPZLRUNSMO-UHFFFAOYSA-N

物化性质

• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  13.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.13
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (RS)-5-benzylpyrazolidin-3-one 、 乙酸酐 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以81%的产率得到1-acetyl-5-benzylpyrazolidin-3-one
  参考文献：
  名称：

  A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines

  摘要：

  The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corresponding triflates and smoothly coupled to a variety of aryl- and heteroarylboronic acids. This process and its broad scope constitute a rapid, divergent strategy for the synthesis of elaborated 2-pyrazolines that are not readily obtained via conventional methods.

  DOI：

  10.1021/jo9011859
• 作为产物：
  描述：

  4-Phenyl-crotonsaeure-aethylester 在 一水合肼 作用下， 以 乙醇 为溶剂， 以76%的产率得到(RS)-5-benzylpyrazolidin-3-one
  参考文献：
  名称：

  A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines

  摘要：

  The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corresponding triflates and smoothly coupled to a variety of aryl- and heteroarylboronic acids. This process and its broad scope constitute a rapid, divergent strategy for the synthesis of elaborated 2-pyrazolines that are not readily obtained via conventional methods.

  DOI：

  10.1021/jo9011859

文献信息

• The development of highly active acyclic chiral hydrazides for asymmetric iminium ion organocatalysis
  作者：Eoin Gould、Tomas Lebl、Alexandra M. Z. Slawin、Mark Reid、Tony Davies、Andrew D. Smith

  DOI：10.1039/c3ob41719k

  日期：——

  Double asymmetric induction has been employed as a tool to optimise pyrazolidinone-derived organocatalysts for the asymmetric iminium ion catalysed Diels–Alder reaction. Mechanistic studies revealed a superior hydrazide catalyst deriving from methanolysis of the chiral pyrazolidinone precursor. This catalyst displays unusually high endo diastereoselectivity and good enantioselectivity with a range

  双不对称感应已被用作优化吡唑烷酮衍生的有机催化剂用于不对称亚胺离子催化的Diels-Alder反应的工具。机理研究表明，一种优异的酰肼催化剂是由手性吡唑烷酮前体的甲醇分解反应而得。该催化剂在低至1 mol％的催化剂负载下显示出异常高的内非对映选择性和良好的对映选择性，以及一系列β-芳烃和环状二烯。
• A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines
  作者：Jonathan B. Grimm、Kevin J. Wilson、David J. Witter

  DOI：10.1021/jo9011859

  日期：2009.8.21

  The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corresponding triflates and smoothly coupled to a variety of aryl- and heteroarylboronic acids. This process and its broad scope constitute a rapid, divergent strategy for the synthesis of elaborated 2-pyrazolines that are not readily obtained via conventional methods.