L-谷氨酸=gamma-肼 | 1820-73-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-谷氨酸=gamma-肼
• 中文别名: L-谷氨酸酰肼
• 英文名称: glutamic acid γ-hydrazide
• 英文别名: γ-L-glutamyl hydrazide；γ-L-glutamyl hydrazine；(S)-Glu-γ-NHNH₂；L-Glutaminsaeure-γ-hydrazid；N-L-γ-Glutamyl-hydrazin；L-2-Amino-glutarsaeure-5-hydrazid；L-Glutaminsaeure-5-hydrazid；L-glutamic acid-5-hydrazide；(2S)-2-azaniumyl-5-hydrazinyl-5-oxopentanoate
• CAS: 1820-73-1
• 化学式: C₅H₁₁N₃O₃
• 分子量: 161.161
• InChiKey: MOFBPUBBBREDCE-VKHMYHEASA-N

物化性质

• 熔点：
  164-165℃ C
• 沸点：
  478.1±40.0 °C(Predicted)
• 密度：
  1.350±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• WGK Germany：
  3
• 海关编码：
  2928000090

SDS

---

Section 1. Chemical Product and Company Identification
L-Glutamic acid gamma-hydrazide
Common Name/
Trade Name
Manufacturer
Commercial Name(s)
Synonym
Chemical Name
Chemical Family
L-Glutamic acid gamma-hydrazide

---

Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion Not available.

---

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
Products of Combustion These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

---

Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
L-Glutamic acid gamma-hydrazide

---

Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
breathe dust.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area. Freeze

---

Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection
Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

---

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. Odor Not available.
Taste Not available.
Molecular Weight 161.16 g/mole
Color Not available.
pH (1% soln/water) Not available.
Boiling Point Not available.
Melting Point Not available.
Critical Temperature Not available.
Not available.
Specific Gravity
Vapor Pressure Not applicable.
Vapor Density Not available.
Volatility Not available.
Odor Threshold Not available.
Not available.
Water/Oil Dist. Coeff.
Ionicity (in Water) Not available.
Not available.
Dispersion Properties
Solubility Not available.

---

Section 10. Stability and Reactivity Data
Stability The product is stable.
Not available.
Instability Temperature
Conditions of Instability Exess heat, incompatible materials
Incompatibility with various Not available.
substances
Corrosivity Not available.
L-Glutamic acid gamma-hydrazide
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization Will not occur.

---

Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on
Not available.
Chronic Effects on Humans
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation.
Eyes: Dust may cause eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: Expected to be a low hazard for ingestion

---

Section 12. Ecological Information
Ecotoxicity Not available.
BOD5 and COD Not available.
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The product itself and its products of degradation are not toxic.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation

---

Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental
control regulations.

---

Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Identification Not applicable.
Special Provisions for Not applicable.
Transport
L-Glutamic acid gamma-hydrazide
DOT (Pictograms)

---

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California California prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) This product is not classified according Not applicable.
to the EU regulations.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
L-Glutamic acid gamma-hydrazide

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  L-谷氨酸=gamma-肼 在 乙醇 、 镍 作用下， 生成 L-谷氨酰胺
  参考文献：
  名称：

  Akabori; Narita, Proceedings of the Japan Academy, 1953, vol. 29, p. 264

  摘要：

  DOI：
• 作为产物：
  描述：

  L-焦谷氨酸 在 肼 作用下， 以 乙醇 、 水 为溶剂， 以24.6%的产率得到L-谷氨酸=gamma-肼
  参考文献：
  名称：

  The Synthesis of Anthglutin and Its Analogues

  摘要：

  合成了Anthglutin（1-γ-l-谷氨酰-2-(2-羧基苯基)肼）及其类似物，并测量了它们对γ-谷氨酰转肽酶的抑制活性。包括Anthglutin在内的2-羧基苯基衍生物表现出抑制活性，而其他衍生物则没有。2-羧基似乎对抑制活性是必不可少的。

  DOI：

  10.1246/bcsj.54.2219

文献信息

• In Situ Deprotection and Incorporation of Unnatural Amino Acids during Cell-Free Protein Synthesis
  作者：Isaac N. Arthur、James E. Hennessy、Dharshana Padmakshan、Dannon J. Stigers、Stéphanie Lesturgez、Samuel A. Fraser、Mantas Liutkus、Gottfried Otting、John G. Oakeshott、Christopher J. Easton

  DOI：10.1002/chem.201203923

  日期：2013.5.17

  (DE3) used for cell‐free protein synthesis removes a wide range of α‐amino acid protecting groups by cleaving α‐carboxyl hydrazides; methyl, benzyl, tert‐butyl, and adamantyl esters; tert‐butyl and adamantyl carboxamides; α‐amino form‐, acet‐, trifluoroacet‐, and benzamides; and side‐chain hydrazides and esters. The free amino acids are produced and incorporated into a protein under standard conditions

  大肠杆菌BL21 Star（DE3）的S30提取物可用于无细胞蛋白质合成，可通过裂解α-羧基酰肼去除大量的α-氨基酸保护基团。甲基，苄基，叔丁基和金刚烷基酯; 叔丁基和金刚烷酰胺; α-氨基甲酰胺，乙酰胺，三氟乙酰胺和苯甲酰胺; 以及侧链酰肼和酯。在标准条件下产生游离氨基酸并将其掺入蛋白质中。该方法允许在原位进行氨基酸的脱保护以避免单独的加工步骤。这种方法的优势通过有效结合化学难治性（S）-4-氟亮氨酸（S）-4,5-脱氢亮氨酸和（2 S，3 R）-4-氯缬氨酸通过直接使用它们各自的前体即（S）-4-氟亮氨酸酰肼（S）-4,5转变成蛋白质脱氢亮氨酸酰肼和（2 S，3 R）-4-氯缬氨酸甲酯。这些结果还表明，氟，脱氢亮氨酸和氯缬氨酸通过正常的生物合成机制被掺入蛋白质中，分别代替亮氨酸和异亮氨酸。
• Substrate Specificity and Chemical Mechanism for the Reaction Catalyzed by Glutamine Kinase
  作者：Zane W. Taylor、Alexandra R. Chamberlain、Frank M. Raushel

  DOI：10.1021/acs.biochem.8b00811

  日期：2018.9.18

  through a three-step reaction mechanism via the formation of covalent pyrophosphorylated (Enz-X-Pβ-Pγ) and phosphorylated (Enz-X-Pβ) intermediates. In the absence of l-glutamine, the enzyme was shown to catalyze a positional isotope exchange (PIX) reaction within β-[18O4]-ATP in support of the formation of the Enz-X-Pβ-Pγintermediate. In the absence of ATP, the enzyme was shown to catalyze a molecular isotope

  空肠弯曲杆菌是全球肠胃炎的主要原因，其荚膜多糖具有独特的氨基磷酸O-甲基氨基磷酸酯（MeOPN）部分。调查MeOPN的生物学作用已表明它有助于致病性空肠弯曲菌，而这种修改是定植重要空肠弯曲杆菌。以前，已经阐明了由空肠弯曲杆菌的四种酶（Cj1418–Cj1415）催化的氨基磷酸酯修饰生物合成所需的反应。Cj1418（1-谷氨酰胺激酶）催化最初的氨基磷酸酯键的形成以及l的酰胺氮的ATP依赖性磷酸化-谷氨酰胺。在这里，我们表明，Cj1418催化的磷酸化升通过共价pyrophosphorylated的形成通过一个三步反应机理谷氨酰胺（ENZ-X -P β -P γ）和磷酸化（ENZ-X -P β）的中间体。在没有升谷氨酰胺，所述酶显示出内β-[催化的位置同位素交换（PIX）反应18 ø 4支持的形成] -ATP ENZ-X -P β -P γ中间。在没有ATP的情况下，该酶被证明可以催化之间的分子
• Central Stimulants. Chemistry and Structure-Activity Relationship of Aralkyl Hydrazines
  作者：John H. Biel、Alexander E. Drukker、Thomas F. Mitchell、Edwin P. Sprengeler、Patrick A. Nuhfer、Alvin C. Conway、A. Horita

  DOI：10.1021/ja01520a048

  日期：1959.6
• Roper; McIlwain, Biochemical Journal, 1948, vol. 42, p. 488
  作者：Roper、McIlwain

  DOI：——

  日期：——
• Lepp; Dunn, Biochemical Preparations, 1957, vol. 5, p. 79,82
  作者：Lepp、Dunn

  DOI：——

  日期：——

表征谱图