7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-3-id-2-one;gold(1+);triphenylphosphane | 207515-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-3-id-2-one;gold(1+);triphenylphosphane
• CAS: 207515-11-5
• 化学式: C₃₄H₂₇AuClN₂OP
• 分子量: 742.994
• InChiKey: UAJYETVOWXPJNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-3-id-2-one;gold(1+);triphenylphosphane 以 甲醇 、 乙醇 为溶剂， 生成 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-3-id-2-one;gold(1+);triphenylphosphane;tetrafluoroborate
  参考文献：
  名称：

  C(3) aurated 1,4-benzodiazepin-2-ones. Synthesis and characterization. Crystal structure of (L)Au[P(C6H4CH3-4)3] (HL=7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, DIAZEPAM)

  摘要：

  The synthesis of a series of gold(I) metallated derivatives of some 1,4-benzodiazepin-2-ones is described. They include mononuclear (L)Au(PR3) (R = C6H5, C6H4CH3-4 or C2H5) as well as dinuclear species (L)Au(Ph2P(CH2) PPh2)Au(L), n = 2, 3 (HL = 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, DIAZEPAM or 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, PRAZEPAM). The deprotonated ligand is bonded to the AuPR3 moiety through the C(3) atom. Activation of the C(sp(3))-H bond is achieved by means of a strong base in the presence of the phosphinegold chloride intermediate. The structure of (L)Au[P(C6H5CH3-4)(3)] has been determined by X-ray diffraction. Some aspects of the reactivity of the metallated species is also reported. (C) 1998 Elsevier Science S.A.

  DOI：

  10.1016/s0022-328x(97)00624-4
• 作为产物：
  描述：

  三苯基膦氯金 、 地西泮 在 KOH 作用下， 以 乙醇 为溶剂， 以63%的产率得到7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-3-id-2-one;gold(1+);triphenylphosphane
  参考文献：
  名称：

  C(3) aurated 1,4-benzodiazepin-2-ones. Synthesis and characterization. Crystal structure of (L)Au[P(C6H4CH3-4)3] (HL=7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, DIAZEPAM)

  摘要：

  The synthesis of a series of gold(I) metallated derivatives of some 1,4-benzodiazepin-2-ones is described. They include mononuclear (L)Au(PR3) (R = C6H5, C6H4CH3-4 or C2H5) as well as dinuclear species (L)Au(Ph2P(CH2) PPh2)Au(L), n = 2, 3 (HL = 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, DIAZEPAM or 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, PRAZEPAM). The deprotonated ligand is bonded to the AuPR3 moiety through the C(3) atom. Activation of the C(sp(3))-H bond is achieved by means of a strong base in the presence of the phosphinegold chloride intermediate. The structure of (L)Au[P(C6H5CH3-4)(3)] has been determined by X-ray diffraction. Some aspects of the reactivity of the metallated species is also reported. (C) 1998 Elsevier Science S.A.

  DOI：

  10.1016/s0022-328x(97)00624-4