2,2-dichloro-12-(4-chlorophenoxy)-dodecanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2-dichloro-12-(4-chlorophenoxy)-dodecanoic acid
• 英文别名: 2,2-dichloro-12-(4-chlorophenoxy)dodecanoic acid
• 化学式: C₁₈H₂₅Cl₃O₃
• 分子量: 395.754
• InChiKey: VLYMJILTTUSVNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二氯乙酸 、 1-[(10-bromodecyl)oxy]-4-chloro-benzene 以5.9 g (50%) 11, melting point 63-64° C. was obtained的产率得到2,2-dichloro-12-(4-chlorophenoxy)-dodecanoic acid
  参考文献：
  名称：

  2,2-Dichloroalkanecarboxylic acids, processes for their production and

  摘要：

  治疗糖尿病的药物剂量，其含有公式I中的化合物作为活性物质，其中A，B，A'和W具有声明中所述的含义，公式I的新化合物以及其制备过程。

  公开号：

  US05968982A1

文献信息

• 2,2-Dichloroalkanecarboxylic acids, processes for their production and
  申请人：Roche Diagnostics GmbH

  公开号：US05968982A1

  公开（公告）日：1999-10-19

  Pharmaceutical agents for treating diabetus mellitus which contain a compound of formula I ##STR1## as the active substance, in which A, B, A' and W have the meanings stated in the claims, new compounds of formula I as well as processes for their production.

  治疗糖尿病的药物剂量，其含有公式I中的化合物作为活性物质，其中A，B，A'和W具有声明中所述的含义，公式I的新化合物以及其制备过程。
• 2,2-DICHLORALKANCARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG DIESE ENTHALTENDE ARZNEIMITTEL, UND IHRE VERWENDUNG ZUR BEHANDLUNG DER INSULINRESISTENZ
  申请人：Roche Diagnostics GmbH

  公开号：EP0790824B1

  公开（公告）日：2002-02-06
• US5968982A
  申请人：——

  公开号：US5968982A

  公开（公告）日：1999-10-19
• ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents
  作者：Kirstin Meyer、Edgar Voss、Richard Neidlein、Hans-Frieder Kühnle、Johannes Pill

  DOI：10.1016/s0223-5234(99)80029-4

  日期：1998.10

  In screening experiments certain omega-substituted alkyl carboxylic acids were found to produce an increase in insulin-stimulated C-14-acetate incorporation into triglycerides, which may indicate an improvement in the action of insulin. Antidiabetic and lipid-lowering properties in genetically diabetic ob/ob mice demonstrated the in vivo relevance of the insulin-potentiating effects seen in vitro. The chemical structures of the w-substituted alkyl carboxylic acids with insulin-potentiating effects correspond to the general formula ring-spacer-COOH. A close structure-activity relationship was observed. The most potent compound in ob/ob mice was 3e, which normalized blood glucose as well as hyperinsulinaemia and lowered serum triglycerides and cholesterol by 52% and 37%, respectively. On the basis of these results, omega-substituted alkyl carboxylic acids are interesting as a new class of oral antidiabetic agents with insulin-sensitizing and lipid-lowering activity. (C) Elsevier, Paris.