5-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione | 1484-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione
• 英文别名: 1-Phenyl-thymin；5-methyl-1-phenylpyrimidine-2,4-dione
• CAS: 1484-93-1
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.213
• InChiKey: JFIGUZOJHCKWSU-UHFFFAOYSA-N

物化性质

• 熔点：
  200 °C (decomp)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-methoxy-N-(phenylaminocarbonyl)2-methyl-2-propenamide 在 sodium hydroxide 作用下， 生成 5-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  33.嘌呤，嘧啶和乙二醛。第八部分 尿嘧啶和胸腺嘧啶的新合成

  摘要：

  DOI：

  10.1039/jr9580000157

文献信息

• Pyrimidinedione, pyrimidinetrione, triazinedione and
  申请人：Syntex (U.S.A.) Inc.

  公开号：US05859014A1

  公开（公告）日：1999-01-12

  Compounds of Formula I: ##STR1## where R.sup.5 is a group selected from Formulae (a), (b), (c) and (d): ##STR2## and the pharmaceutically acceptable salts and N-oxides thereof, are .alpha..sub.1 -adrenergic receptor antagonists useful for the treatment of diseases involving directly or indirectly an obstruction of the lower urinary tract, such as benign prostatic hyperplasia.

  化合物的化学式I：##STR1##其中R.sup.5是从式(a)、(b)、(c)和(d)中选择的基团：##STR2##以及其药用可接受的盐和N-氧化物，是用于治疗涉及直接或间接阻塞下尿道的疾病，如良性前列腺增生的α1-肾上腺素受体拮抗剂。
• COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
  申请人：Kossen Karl

  公开号：US20090318455A1

  公开（公告）日：2009-12-24

  Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

  公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物对p38 MAPK的抑制效力较低；并且其中接触是在SAPK调节浓度下进行的，该浓度对化合物抑制p38 MAPK的抑制浓度百分比较低。还公开了吡非尼酮的衍生物和类似物，它们可用于调节应激活化蛋白激酶（SAPK）系统。
• Hypervalent Iodine in Synthesis. Part?86
  作者：Tao Zhou、Ti-Cong Li、Zhen-Chu Chen

  DOI：10.1002/hlca.200590010

  日期：2005.2

  N-Arylation of uracil and its derivatives 2 with diaryliodonium salts 1 was investigated in order to explore a new synthetic methodology associated with N-aryluracil derivatives. In the presence of K2CO3, the copper-catalyzed arylation gave N1,N3-diarylation products with high selectivity and in good yields (Table 2). However, the use of NaOAc as the base in the copper-catalyzed arylation of 6-methyluracil

  Ñ尿嘧啶-Arylation及其衍生物2与二芳基碘盐1为了探索与相关联的新的合成方法进行了研究Ñ -aryluracil衍生物。在K 2 CO 3的存在下，铜催化的芳基化反应具有高选择性和高收率的N 1，N 3-二芳基化产物（表2）。但是，使用NaOAc作为碱在铜催化的6-甲基尿嘧啶（2a）的芳基化反应中产生具有高选择性的N 3-芳基化产物，以及铜催化的尿嘧啶的芳基化（2b）或5-甲基尿嘧啶（=胸腺嘧啶; 2c），N 1-芳基化产物是主要产物（表3）。
• A Mild and Efficient Method for<i>N</i>‐Arylnucleobase Synthesis<i>via</i>the Cross‐Coupling Reactions of Nucleobases with Arylboronic Acids Catalyzed by Simple Copper Salts
  作者：Lan Tao、Yang Yue、Ji Zhang、Shan‐Yong Chen、Xiao‐Qi Yu

  DOI：10.1002/hlca.200890107

  日期：2008.6

  A simple and efficient copper-salt catalyzed N-arylation of nucleobases is reported. In a mixed solvent of MeOH and H2O, the coupling products were obtained in moderate to excellent yields at room temperature within a short time. A variety of substituted N-aryl nucleobases can be prepared through this procedure.

  报道了一种简单而有效的铜盐催化的核碱基的N-芳基化。在MeOH和H 2 O的混合溶剂中，在短时间内在室温下以中等至优异的产率获得偶联产物。通过该程序可以制备各种取代的N-芳基核碱基。
• Phenylation of pyrimidinones using diphenyliodonium salts
  作者：Stig André Jacobsen、Synne Rødbotten、Tore Benneche

  DOI：10.1039/a905519c

  日期：——

  Pyrimidinones 1 have been phenylated under basic conditions using diphenyliodonium salts, and the effect of substituents on the yield and regiochemistry has been studied.

  已在碱性条​​件下使用二苯基碘鎓盐将嘧啶酮1苯酚化，并研究了取代基对收率和区域化学的影响。