nitric acid-(β-amino-isopropyl ester) | 65141-49-3

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: nitric acid-(β-amino-isopropyl ester)
• 英文别名: 2-Nitryloxy-propylamin；Salpetersaeure-(β-amino-isopropylester)；1-Aminopropan-2-yl nitrate
• CAS: 65141-49-3
• 化学式: C₃H₈N₂O₃
• 分子量: 120.108
• InChiKey: DVWRRIIWVSOUOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  nitric acid-(β-amino-isopropyl ester) 、 丙半胱氨酸 在 焦碳酸二乙酯 作用下， 生成 (4R)-N-(2-Nitrooxypropyl)-2-oxothiazolidine-4-carboxamide
  参考文献：
  名称：

  Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties

  摘要：

  To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00199-9
• 作为产物：
  描述：

  异丙醇胺 在 硝酸 作用下， 生成 nitric acid-(β-amino-isopropyl ester)
  参考文献：
  名称：

  Korzycka, Polish Journal of Chemistry, 2003, vol. 77, # 5, p. 557 - 563

  摘要：

  DOI：

文献信息

• Korzycka, Polish Journal of Chemistry, 2003, vol. 77, # 5, p. 557 - 563
  作者：Korzycka

  DOI：——

  日期：——
• Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties
  作者：Sadao Ishihara、Fujio Saito、Yasuo Ohhata、Marie Kanai、Hiroshi Mizuno、Michio Fujisawa、Ryosuke Yorikane、Hiroyuki Koike

  DOI：10.1016/s0960-894x(03)00199-9

  日期：2003.5

  To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.