[二氟(苯硫基)甲基]三甲基硅烷 | 536975-49-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: [二氟(苯硫基)甲基]三甲基硅烷
• 英文名称: phenyl (trimethylsilyl)difluoromethyl sulfide
• 英文别名: [difluoro(phenylthio)methyl]trimethylsilane；[difluoro(phenylsulfanyl)methyl]trimethylsilane；(Difluoro(phenylthio)methyl)trimethylsilane；[difluoro(phenylsulfanyl)methyl]-trimethylsilane
• CAS: 536975-49-2
• 化学式: C₁₀H₁₄F₂SSi
• 分子量: 232.369
• InChiKey: NNNLERGMVGBYSD-UHFFFAOYSA-N

物化性质

• 溶解度：
  soluble in most organic solvents, for example hexane, tetrahydrofuran (THF), CH2Cl2, dimethylformamide (DMF), and so on.

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [二氟(苯硫基)甲基]三甲基硅烷 在 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate 、 二氧化硫 、 N,N-二异丙基乙胺 、 cesium fluoride 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 21.5h， 生成 N-benzyl-N-(trifluoromethanesulfonyl)-(phenylsulfanyl)difluoromethanesulfonamide
  参考文献：
  名称：

  Syntheses of a wide family of new aryl based perfluorosulfonimide lithium salts. Electrochemical performances of the related polymer electrolytes

  摘要：

  This paper reports both on a general multistep synthesis of a wide family of aryl substituted perfluorosulfonimides and on a preliminary electrochemical investigation of two lithium salts hosted by a poly(oxyethylene) homopolymer. Both salts have a cationic transference number more than twice that of LiTFSI. Additionally, one of these salts exhibits markedly higher cationic conductivities than POE/LiTFSI electrolytes. These preliminary data are very encouraging as, thanks to the aryl moiety, a wide variety of salts can be considered in order to still improve the performances of polymer electrolytes. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2011.06.041
• 作为产物：
  描述：

  [(bromodifluoromethyl)sulfanyl]benzene 以 N,N-二甲基甲酰胺 为溶剂， 以85%的产率得到[二氟(苯硫基)甲基]三甲基硅烷
  参考文献：
  名称：

  Magnesium mediated preparation of fluorinated alkyl silanes

  摘要：

  揭示了一种高效的方法，用于利用镁金属介导氯硅烷与三氟甲基硫化物、亚氧化物和砜发生还原三氟甲基和二氟甲基基团的反应制备三氟甲基和二氟甲基硅烷。该过程的副产物之一是二苯基二硫化物。由于苯基三氟甲基砜、亚氧化物和硫化物可以从易得的三氟甲烷和二苯基二硫化物制备而来，因此该方法可以被认为是用于从环境友好的三氟甲烷制备（三氟甲基）三甲基硅烷的“伪催化”方法。

  公开号：

  US20030153778A1

文献信息

• An easier and quicker access to (benzenesulfonyl)difluoromethanesulfenamide reagent
  作者：Ermal Ismalaj、Thierry Billard

  DOI：10.1016/j.jfluchem.2017.07.001

  日期：2017.11

  (Benzenesulfonyl)difluoromethanesulfenamide (PhSO2-BB12H) is an interesting reagent to lead to various fluoroalkylselenotated molecules. This compound is obtained from [(benzenesulfonyl)difluoromethyl]trimethylsilane. Herein, a new process in two steps, without intermediate purifications, is described to easily synthesize this product. With this new method, preparation of PhSO2-BB12H reagent has been

  （苯磺酰基）二氟甲亚磺酰胺（PhSO2-BB12H）是引起各种氟代烷基硒代化分子的有趣试剂。该化合物由[（苯磺酰基）二氟甲基]三甲基硅烷获得。在此，描述了不经中间纯化就分两步进行的新方法，以容易地合成该产物。使用这种新方法，仅需3个步骤即可完成PhSO2-BB12H试剂的制备，仅需进行一次纯化即可，并且具有良好的总收率。
• Preparation of Tri- and Difluoromethylsilanes via an Unusual Magnesium Metal-Mediated Reductive Tri- and Difluoromethylation of Chlorosilanes Using Tri- and Difluoromethyl Sulfides, Sulfoxides, and Sulfones
  作者：G. K. Surya Prakash、Jinbo Hu、George A. Olah

  DOI：10.1021/jo030110z

  日期：2003.5.1

  A new and efficient method for the preparation of tri- and difluoromethylsilanes using magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes is reported using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. The byproduct of the process is diphenyl disulfide. Since phenyl trifluoromethyl sulfone, sulfoxide, and sulfide are readily prepared from trifluoromethane

  据报道，使用三和二氟甲基硫化物，亚砜和砜，使用镁金属介导的氯硅烷的三和二氟甲基化还原反应来制备三和二氟甲基硅烷的新的有效方法。该方法的副产物是二苯基二硫化物。由于可以很容易地从三氟甲烷（CF（3）H）和二苯基二硫化物制备苯基三氟甲基砜，亚砜和硫化物，因此该方法可以认为是二苯基二硫化物的催化方法，用于制备（三氟甲基）三甲基硅烷（TMS-CF（3 ））来自不消耗臭氧的三氟甲烷。
• COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS
  申请人：Fan Yi

  公开号：US20120065184A1

  公开（公告）日：2012-03-15

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.

  该发明提供了化合物、包含该化合物的药物组合物以及使用该化合物治疗或预防与TRK激酶活性异常或失调相关的疾病或病症的方法。
• AROMATIC SULPHONYLIMIDES, PREPARATION THEREOF AND USE THEREOF AS ELECTROLYTE
  申请人：Sanchez Jean-Yves

  公开号：US20100174113A1

  公开（公告）日：2010-07-08

  The invention relates to a process for preparing aromatic sulphonylimides, to the sulphonylimides obtained, and to the use thereof as salt of an electrolyte. The sulphonylimides correspond to the formula [R—SO 2 —N—SO 2 R′] r M (I). R′ is an ArZL- group. R′ is a perfluoroalkyl group or an ArZL- group. Z is an S, SO or SO 2 group. L is a —(CF 2 ) n —CFR f — group. n is 0 or 1; R f represents F or a C 1 to C 8 perfluoroalkyl group; Ar is an aromatic group. M represents H, an alkali metal cation, an alkaline earth metal cation, a trivalent or tetravalent metal cation, or an organic cation. The process consists in preparing a compound RSO2N(R′)SO2R′ from RSO 2 F, and in replacing the group R′ by nucleophilic substitution reaction so as to obtain the compound (I), R′ being a benzyl or trimethylsilyl group.

  该发明涉及一种制备芳香磺酰亚胺的方法，所得的磺酰亚胺以及将其用作电解质盐。磺酰亚胺对应于式[R—SO2—N—SO2R′]rM（I）。R′是ArZL-基团。R′是全氟烷基基团或ArZL-基团。Z是S、SO或SO2基团。L是—(CF2)n—CFRf—基团。n为0或1；Rf代表F或C1到C8的全氟烷基基团；Ar是芳香族基团。M代表H、碱金属阳离子、碱土金属阳离子、三价或四价金属阳离子或有机阳离子。该方法包括从RSO2F制备化合物RSO2N(R′)SO2R′，并通过亲核取代反应将基团R′替换为以获得化合物（I），其中R′是苄基或三甲基硅基团。
• An Efficient Preparation of New Sulfonyl Fluorides and Lithium Sulfonates
  作者：Fabien Toulgoat、Bernard. R. Langlois、Maurice Médebielle、Jean-Yves Sanchez

  DOI：10.1021/jo701318n

  日期：2007.11.1

  polyfluoroalkanesulfonyl fluorides is reported. This method, based on the synthesis of polyfluoroalkyl trimethyl silanes (precursors of polyfluoroalkylsulfinates) as intermediates, allows the successive transformations to be carried out in one pot. Moreover, these sulfonyl fluorides can be obtained from the corresponding sulfinates by electrophilic fluorination. This original approach avoids isolation and purification

  报道了几种多氟链烷磺酰氟的有效制备方法。该方法基于多氟烷基三甲基硅烷（多氟烷基亚磺酸盐的前体）作为中间体的合成，可以在一个罐中进行连续的转化。而且，这些磺酰氟可以通过亲电氟化从相应的亚磺酸盐获得。这种原始方法避免了某些热或水解不稳定中间体的分离和纯化。因此，已经从卤代二氟甲基化的前体RCF 2 X（X = F，Br; R = ArC（O），ArS（O）n（CF 2）m ; n = 0，1，2; m制备了一系列新的磺酰氟。 = 1、2），并已转化为相应的磺酸锂，它们有潜力用作锂电池的电解质。