5-aminouridine-5'-triphosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 5-aminouridine-5'-triphosphate
• 英文别名: ({[({[(2R,3S,4R,5R)-5-(5-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid；[[(2R,3S,4R,5R)-5-(5-amino-2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₉H₁₆N₃O₁₅P₃
• 分子量: 499.158
• InChiKey: ZPXMYTAGGGFLIP-UAKXSSHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.6
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  285
• 氢给体数：
  8
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  5-aminouridine-5'-triphosphate 在 sodium azide 作用下， 生成 5-azidouridine-5'-triphosphate
  参考文献：
  名称：

  The synthesis of 5-azido-UTP and UDP-pyridoxal and their effect on the carbamoyl-phosphate synthetase (CPS II) in the mammalian multienzyme polypeptide CAD

  摘要：

  5-azidouridine-5'-triphosphate and UDP-pyridoxal have been synthesized using modified synthetic methods. The two synthetic UTP analogues, with commercially available analogues and chemicals have been tested for their effect on CPSase II in the mammalian multienzyme polypeptide CAD. Structure activity relationships are discussed. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00452-0
• 作为产物：
  描述：

  尿苷-5'-三磷酸 在 盐酸 、 nitrosonium tetrafluoroborate 、 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-aminouridine-5'-triphosphate
  参考文献：
  名称：

  The synthesis of 5-azido-UTP and UDP-pyridoxal and their effect on the carbamoyl-phosphate synthetase (CPS II) in the mammalian multienzyme polypeptide CAD

  摘要：

  5-azidouridine-5'-triphosphate and UDP-pyridoxal have been synthesized using modified synthetic methods. The two synthetic UTP analogues, with commercially available analogues and chemicals have been tested for their effect on CPSase II in the mammalian multienzyme polypeptide CAD. Structure activity relationships are discussed. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00452-0

文献信息

• Modified nucleotides and methods of labeling nucleic acids
  申请人：Anderson D. Jack

  公开号：US20050003371A1

  公开（公告）日：2005-01-06

  The invention relates to functionalized nucleotides that permit the covalent linkage of the nucleotides to moieties containing reactive groups complementary to the functional group. More specifically, the invention relates to nucleotides comprising a functional group attached to the nucleobase that permits the covalent attachment of the nucleotides or a nucleic acid comprising such nucleotides to detectable moieties, polypeptides and solid supports. The invention further relates to nucleic acids comprising such functionalized nucleotides, methods of labeling nucleic acids with such nucleotides, and kits comprising such nucleotides.

  本发明涉及可使核苷酸与含有与官能团互补的活性基团的分子共价连接的官能化核苷酸。更具体地说，本发明涉及核苷酸，该核苷酸包含一个连接到核碱基上的官能团，该官能团允许该核苷酸或包含该核苷酸的核酸与可检测分子、多肽和固体支持物共价连接。本发明还涉及包含这种功能化核苷酸的核酸、用这种核苷酸标记核酸的方法以及包含这种核苷酸的试剂盒。
• [EN] MODIFIED NUCLEOTIDES AND METHODS OF LABELING NUCLEIC ACIDS<br/>[FR] NUCLEOTIDES MODIFIES ET PROCEDES DE MARQUAGE D'ACIDES NUCLEIQUES
  申请人：STRATAGENE INC

  公开号：WO2004037989A2

  公开（公告）日：2004-05-06

  The invention relates to functionalized nucleotides that permit the covalent linkage of the nucleotides to moieties containing reactive groups complementary to the functional group. More specifically, the invention relates to nucleotides comprising a functional group attached to the nucleobase that permits the covalent attachment of the nucleotides or a nucleic acid comprising such nucleotides to detectable moieties, polypeptides and solid supports. The invention further relates to nucleic acids comprising such functionalized nucleotides, methods of labeling nucleic acids with such nucleotides, and kits comprising such nucleotides.