5-nitrouridine-5'-triphosphate | 185307-80-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-nitrouridine-5'-triphosphate
• 英文别名: [[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-nitro-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxy-oxidophosphaniumyl]oxy-hydroxyphosphoryl]oxyphosphonic acid
• CAS: 185307-80-6
• 化学式: C₉H₁₄N₃O₁₇P₃
• 分子量: 529.141
• InChiKey: LEPSRTMDAUYLBM-UAKXSSHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  317
• 氢给体数：
  7
• 氢受体数：
  17

反应信息

• 作为反应物：
  描述：

  5-nitrouridine-5'-triphosphate 在 盐酸 、 sodium azide 、 锌 作用下， 反应 0.67h， 生成 5-azidouridine-5'-triphosphate
  参考文献：
  名称：

  The synthesis of 5-azido-UTP and UDP-pyridoxal and their effect on the carbamoyl-phosphate synthetase (CPS II) in the mammalian multienzyme polypeptide CAD

  摘要：

  5-azidouridine-5'-triphosphate and UDP-pyridoxal have been synthesized using modified synthetic methods. The two synthetic UTP analogues, with commercially available analogues and chemicals have been tested for their effect on CPSase II in the mammalian multienzyme polypeptide CAD. Structure activity relationships are discussed. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00452-0
• 作为产物：
  描述：

  尿苷-5'-三磷酸 在 nitrosonium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-nitrouridine-5'-triphosphate
  参考文献：
  名称：

  The synthesis of 5-azido-UTP and UDP-pyridoxal and their effect on the carbamoyl-phosphate synthetase (CPS II) in the mammalian multienzyme polypeptide CAD

  摘要：

  5-azidouridine-5'-triphosphate and UDP-pyridoxal have been synthesized using modified synthetic methods. The two synthetic UTP analogues, with commercially available analogues and chemicals have been tested for their effect on CPSase II in the mammalian multienzyme polypeptide CAD. Structure activity relationships are discussed. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00452-0

文献信息

• The synthesis of 5-azido-UTP and UDP-pyridoxal and their effect on the carbamoyl-phosphate synthetase (CPS II) in the mammalian multienzyme polypeptide CAD
  作者：Li-Min Zhu、Elizabeth A. Carrey

  DOI：10.1016/0960-894x(96)00452-0

  日期：1996.11

  5-azidouridine-5'-triphosphate and UDP-pyridoxal have been synthesized using modified synthetic methods. The two synthetic UTP analogues, with commercially available analogues and chemicals have been tested for their effect on CPSase II in the mammalian multienzyme polypeptide CAD. Structure activity relationships are discussed. Copyright (C) 1996 Elsevier Science Ltd