6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid | 157116-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid
• 英文别名: 6-[[(2-Methylpropan-2-yl)oxycarbonyl-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]amino]methyl]pyridine-2-carboxylic acid
• CAS: 157116-48-8
• 化学式: C₁₉H₂₉N₃O₆
• 分子量: 395.456
• InChiKey: GAURJVNCVKEOCH-UHFFFAOYSA-N

物化性质

• 沸点：
  560.9±50.0 °C(predicted)
• 密度：
  1.188±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 生成 6-[(2-Amino-ethylamino)-methyl]-pyridine-2-carboxylic acid [2-(5-nitro-1H-imidazol-4-yl)-ethyl]-amide
  参考文献：
  名称：

  Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues

  摘要：

  Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of Fe(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00467-3
• 作为产物：
  描述：

  6-甲酰基-2-吡啶甲酸甲酯 在 palladium on activated charcoal sodium hydroxide 、 氢气 作用下， 生成 6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues

  摘要：

  Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of Fe(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00467-3

文献信息

• Design and synthesis of DNA cleaving bleomycin models: 1,2-trans-disubstituted cyclopropane units as novel linkers
  作者：Liren Huang、James C. Quada、J.William Lown

  DOI：10.1016/s0040-4039(00)73490-3

  日期：1994.7

  The design and synthesis of 1a - e functional models for bleomycin are described in which AMPHIS, a metal-complexing model of bleomycin, and a distamycin moiety are connected with a series of linkers. Studies on the rates of DNA breakage and a mobility assay of DNA cleavage ability show that trans-1,2-disubstituted cyclopropane units are the best linkers amongst those examined.
• Highficld, Jackie A.; Mehta, Lina K.; Patrick, John, Journal of the Chemical Society. Perkin transactions I, 1999, # 16, p. 2343 - 2351
  作者：Highficld, Jackie A.、Mehta, Lina K.、Patrick, John、Candeias, Luis P.、Wardman, Peter

  DOI：——

  日期：——
• Molecular diversity approach to the synthesis of peptide-derived ruthenium complexes and their evaluation as oxidation catalysts
  作者：Amarnath Natarajan、Jose S Madalengoitia

  DOI：10.1016/s0040-4039(00)00851-0

  日期：2000.7

  This paper reports the synthesis of a small library of peptide-derived ruthenium complexes as potential oxidation catalysts. Evaluation of the solid-supported complexes identified several potentially promising epoxidation catalysts. Liberation of the promising catalysts from the solid-support resulted in catalysts with improved activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues
  作者：Jackie A. Highfield、Lina K. Mehta、John Parrick、Luis P. Candeias、Peter Wardman

  DOI：10.1016/s0960-894x(98)00467-3

  日期：1998.9

  Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of Fe(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured. (C) 1998 Elsevier Science Ltd. All rights reserved.