6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid methyl ester | 157116-47-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid methyl ester
• 英文别名: Methyl 6-[[(2-methylpropan-2-yl)oxycarbonyl-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]amino]methyl]pyridine-2-carboxylate；methyl 6-[[(2-methylpropan-2-yl)oxycarbonyl-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]amino]methyl]pyridine-2-carboxylate
• CAS: 157116-47-7
• 化学式: C₂₀H₃₁N₃O₆
• 分子量: 409.483
• InChiKey: JITRTSCOLPWAAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid methyl ester 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以88%的产率得到6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid
  参考文献：
  名称：

  Molecular diversity approach to the synthesis of peptide-derived ruthenium complexes and their evaluation as oxidation catalysts

  摘要：

  This paper reports the synthesis of a small library of peptide-derived ruthenium complexes as potential oxidation catalysts. Evaluation of the solid-supported complexes identified several potentially promising epoxidation catalysts. Liberation of the promising catalysts from the solid-support resulted in catalysts with improved activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00851-0
• 作为产物：
  描述：

  6-甲酰基-2-吡啶甲酸甲酯 在 palladium on activated charcoal 3 A molecular sieve 、 氢气 作用下， 以 二氯甲烷 为溶剂， 生成 6-{[tert-Butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Molecular diversity approach to the synthesis of peptide-derived ruthenium complexes and their evaluation as oxidation catalysts

  摘要：

  This paper reports the synthesis of a small library of peptide-derived ruthenium complexes as potential oxidation catalysts. Evaluation of the solid-supported complexes identified several potentially promising epoxidation catalysts. Liberation of the promising catalysts from the solid-support resulted in catalysts with improved activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00851-0

文献信息

• Highficld, Jackie A.; Mehta, Lina K.; Patrick, John, Journal of the Chemical Society. Perkin transactions I, 1999, # 16, p. 2343 - 2351
  作者：Highficld, Jackie A.、Mehta, Lina K.、Patrick, John、Candeias, Luis P.、Wardman, Peter

  DOI：——

  日期：——
• Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues
  作者：Jackie A. Highfield、Lina K. Mehta、John Parrick、Luis P. Candeias、Peter Wardman

  DOI：10.1016/s0960-894x(98)00467-3

  日期：1998.9

  Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of Fe(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Molecular diversity approach to the synthesis of peptide-derived ruthenium complexes and their evaluation as oxidation catalysts
  作者：Amarnath Natarajan、Jose S Madalengoitia

  DOI：10.1016/s0040-4039(00)00851-0

  日期：2000.7

  This paper reports the synthesis of a small library of peptide-derived ruthenium complexes as potential oxidation catalysts. Evaluation of the solid-supported complexes identified several potentially promising epoxidation catalysts. Liberation of the promising catalysts from the solid-support resulted in catalysts with improved activity. (C) 2000 Elsevier Science Ltd. All rights reserved.