N-(1-氧代十四烷基)-L-谷氨酸(9CI) | 53576-52-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(1-氧代十四烷基)-L-谷氨酸(9CI)
• 英文名称: N-tetradecanoyl-L-glutamic acid
• 英文别名: myristoyl glutamic acid；(2S)-2-(tetradecanoylamino)pentanedioic acid
• CAS: 53576-52-6
• 化学式: C₁₉H₃₅NO₅
• 分子量: 357.491
• InChiKey: MTJZWYHTZFVEGI-INIZCTEOSA-N

物化性质

• LogP：
  4.140 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  十二烷基二甲基叔胺 、 N-(1-氧代十四烷基)-L-谷氨酸(9CI) 以 乙醇 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  pH-sensitive Wormlike Micelle and Hydrogel Formation by Acylglutamic Acid–Alkylamine Complex

  摘要：

  通过形成蠕虫样胶束和水凝胶获得了pH敏感的粘弹性流体。这些聚集体是由脂肪酸谷氨酸（CnGlu）与叔烷基胺以1:1的化学计量比形成的复合物。pH敏感特性反映了CnGlu头部周围电荷密度的变化，从而控制了分子聚集体的曲率。链较长的CnGlu类似物在狭窄的pH区域内产生水凝胶。本研究提出了一种通过类双子表面活性剂获得刺激响应型粘弹性流体的独特方法。

  DOI：

  10.1246/cl.160231
• 作为产物：
  描述：

  肉豆蔻酸酐 在 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 N-(1-氧代十四烷基)-L-谷氨酸(9CI)
  参考文献：
  名称：

  N-Myristoylglutamic acid derivative of 3′-fluoro-3′-deoxythymidine as an organogel

  摘要：

  Designing microbicidal gels of anti-HIV drugs for local application to prevent HIV infection is a subject of major interest. 3'-Fluoro-3'-deoxythymidine (FLT), a nucleoside reverse transcriptase inhibitor (NRTI), was conjugated with a N-myristoylglutamate scaffold. The conjugate showed gelation at 1% (w/w) in different organic solvents, such as toluene, dichloromethane, and chloroform. The gels were opaque and stable at room temperature. The results indicate that myristoyl glutamate derivative of FLT can form an organogel. The gel could have potential application as a topical anti-HIV microbicidal agent. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.101

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] FATTY ACID ACYLATED D-AMINO ACIDS FOR ORAL PEPTIDE DELIVERY<br/>[FR] ACIDES D-AMINÉS ACYLÉS PAR UN ACIDE GRAS POUR L'ADMINISTRATION DE PEPTIDES PAR VOIE ORALE
  申请人：NOVO NORDISK AS

  公开号：WO2014060447A1

  公开（公告）日：2014-04-24

  The present invention relates to fatty acid acylated amino acids (FA-Daa's) acting as permeation enhancers for oral delivery of therapeutic macromolecules such as peptides and pharmaceutical compositions comprising such FA-Daa's.

  本发明涉及脂肪酸酰化氨基酸（FA-Daa's）作为渗透增强剂，用于口服输送治疗性大分子，如肽和包含这种FA-Daa's的药物组合物。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• COSMETIC AND/OR DERMATOLOGICAL COMPOSITION BASED ON N,N'-DIARYLMETHYLENEETHYLENEDIAMINEDIACETIC ACID ESTER(S)
  申请人：KERMORVAN Cecile

  公开号：US20100254922A1

  公开（公告）日：2010-10-07

  The present invention relates to a cosmetic and/or dermatological composition comprising, in a physiologically acceptable medium containing at least one oil: (a) at least one compound of general formula (Ia): and (b) an efficient amount of at least one solvent chosen from: (i) isononyl isononanoate; (ii) dimethyl isosorbide; (iii) the amino acid esters of formula (II): R′ 1 (CO)N(R′ 2 )CH(R′ 3 )(CH 2 ) n (CO)OR′ 4 (II) (iv) and a mixture thereof.

  本发明涉及一种化妆品和/或皮肤科学组合物，其包括在至少含有一种油的生理上可接受的介质中：(a)至少一种通式(Ia)的化合物；和(b)来自以下至少一种溶剂的有效量：(i)异辛酸异壬酯；(ii)二甲基异山梨醇酯；(iii)通式(II)的氨基酸酯：R′1(CO)N(R′2)CH(R′3)(CH2)n(CO)OR′4；(iv)和其混合物。
• Formation of Diverse Mesophases Templated by a Diprotic Anionic Surfactant
  作者：Chuanbo Gao、Yasuhiro Sakamoto、Osamu Terasaki、Shunai Che

  DOI：10.1002/chem.200800766

  日期：——

  synthesis system for mesophase formation, using the diprotic anionic surfactant N-myristoyl-L-glutamic acid (C(14)GluA) as the structure-directing agent (SDA) and N-trimethoxylsilylpropyl-N,N,N-trimethylammonium chloride (TMAPS) as the co-structure-directing agent (CSDA), has been investigated and a full-scaled synthesis-field diagram is presented. In this system we have obtained mesophases including three-dimensional

  使用双质子阴离子表面活性剂N-肉豆蔻酰基-L-谷氨酸（C（14）GluA）作为结构导向剂（SDA）和N-三甲氧基甲硅烷基丙基-N，N，N-三甲基氯化铵（ TMAPS）作为共结构导向剂（CSDA），已经进行了研究，并给出了完整的合成场图。在此系统中，通过改变C（14），我们获得了包括三维（3D）胶束立方立方Fm3m，Pm3n，Fd3m，胶束四边形P4（2）/ mnm，二维（2D）六角形p6mm和双连续立方Pn3m的中间相。 GluA / NaOH / TMAPS组成比。从该图可以得出结论，中间相的形成在很大程度上受到有机/无机界面曲率和介电-介电静电相互作用的影响。在低有机/无机界面曲率区中发现了双连续立方相和二维六方相，而在高有机/无机界面曲率区中发现了胶束立方和四方中间相。立方Fm3m和四方P4（2）/ mnm的形成在具有强介电体-介体相互作用的高碱性区域中受青睐，而立方Pm3n和Fd3