γ-L-glutamyl-S-(trans-1-propenyl)-L-cysteine | 134677-41-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-L-glutamyl-S-(trans-1-propenyl)-L-cysteine
• 英文别名: N-gamma-Glutamyl-S-trans-(1-propenyl)cysteine；(2S)-2-amino-5-[[(1R)-1-carboxy-2-[(E)-prop-1-enyl]sulfanylethyl]amino]-5-oxopentanoic acid
• CAS: 134677-41-1
• 化学式: C₁₁H₁₈N₂O₅S
• 分子量: 290.34
• InChiKey: MUFSTXJBHAEIBT-ZASJQLQOSA-N

物化性质

• 沸点：
  615.4±55.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (2S)-2-amino-5-[[(2R)-1-[[(1R)-1-carboxy-2-[(E)-prop-1-enyl]sulfinylethyl]amino]-1-oxo-3-[(E)-prop-1-enyl]sulfanylpropan-2-yl]amino]-5-oxopentanoic acid 在 carboxypeptidase A 作用下， 反应 25.0h， 生成 isoalliin 、 γ-L-glutamyl-S-(trans-1-propenyl)-L-cysteine
  参考文献：
  名称：

  NATURAL FLAVOUR ENHANCERS AND THE METHOD FOR MAKING SAME

  摘要：

  公开号：

  EP2496097B1

文献信息

• Pharmaceutical unit dosage form comprising 4-phenylbutyric acid
  申请人：Lunamed AG

  公开号：EP2698155A1

  公开（公告）日：2014-02-19

  The invention provides a pharmaceutical unit dosage form comprising 4-phenylbutyric acid (4-PB) as a free acid or as a salt; as a prodrug, a codrug, a co-crystal or any salt or hydrate or solvate thereof. The invention further provides the use of said pharmaceutical dosage form for the prevention or treatment of cancer and methods for preparing said pharmaceutical dosage form.

  本发明提供了一种包含 4-苯基丁酸（4-PB）的药物单位剂型，4-苯基丁酸（4-PB）可以是游离酸或盐；也可以是原药、复方药、共晶体或其任何盐或水合物或溶液。本发明进一步提供了所述药物剂型用于预防或治疗癌症的用途以及制备所述药物剂型的方法。
• Phenylbutyric acid for chemoprevention
  申请人：Lunamed AG

  公开号：EP2698156A1

  公开（公告）日：2014-02-19

  The invention provides a pharmaceutical composition comprising phenylbutyric acid, a derivative, a prodrug, solvate or a physiologically acceptable salt thereof for use in the prevention of cancer. Furthermore pharmaceutical compositions are disclosed which comprise a further chemopreventive agent.

  本发明提供了一种包含苯丁酸、其衍生物、原药、溶液或生理上可接受的盐的药物组合物，用于预防癌症。此外，本发明还公开了包含另一种化学预防剂的药物组合物。
• PLANT EXTRACTS FOR THE TREATMENT OF INCREASED BONE RESORPTION
  申请人：Universität Bern

  公开号：EP1689422A1

  公开（公告）日：2006-08-16
• Plant Extracts for the Treatment of Incresed Bone Resorption
  申请人：Brenneisen Rudolf

  公开号：US20080194492A1

  公开（公告）日：2008-08-14

  The present invention concerns the use of γ-glutamyl-peptide, for example γ-L-glutamyltrans-S-1-propenyl-L-cysteine sulfoxide, in the treatment or prevention of diseases or conditions which are characterized by increased bone resorption, such as Paget's disease, tumor-induced bone disease or osteoporosis, inhibits dose-dependently the resorption activity of osteoclasts, the minimal effective dose being about 2 mM.
• Natural Flavour Enhancers and Methods for Making Same
  申请人：GEORGE Eapen

  公开号：US20110104351A1

  公开（公告）日：2011-05-05

  The present invention pertains to the use of certain flavour enhancing compounds obtainable from an Allium species. In one embodiment, seeds from chives, leeks, ramson and other onions are used for conveying strong kokumi flavour enhancing effects on food products without imparting an onion or garlic-like off taste. These flavour enhancing compounds are also useful for the preparation of Amadori products, which are also used as kokumi flavour enhancing compounds.