5-phenyl-1,2,4,5-tetrahydro-benzo[c]azepin-3-one | 66192-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 5-phenyl-1,2,4,5-tetrahydro-benzo[c]azepin-3-one
• 英文别名: 5-phenyl-1,2,4,5-tetrahydrobenzo[c]azepin-3-one；5-Phenyl-1,2,4,5-tetrahydro-2-(2H)-benzazepin-3-one；5-phenyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-one；5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one
• CAS: 66192-31-2
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: POCNBPQSYBGIQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-Hydroxymethyl-3,3-diphenylpropionamid 在 aluminium chloride 盐酸 作用下， 以 乙醇 、 硝基苯 、 苯 为溶剂， 生成 5-phenyl-1,2,4,5-tetrahydro-benzo[c]azepin-3-one
  参考文献：
  名称：

  1,2,4,5-Tetrahydro-3H-2-benzazepin-3-ones

  摘要：

  新的生理活性1,2,4,5-四氢-3H-2-苯并哌啶-3-酮具有一般化学式##STR1##其中R.sub.1是氢或苯基，R.sub.2是氢，烷基，C.sub.3 -C.sub.6 -烯基，C.sub.1 -C.sub.4 -酰基，羟基烷基，烷氧基烷基，单烷基或双烷基氨基烷基，氰基烷基，烷氧乙酰基，氨基甲酰烷基，乙酰胺-C.sub.2 -C.sub.5 -烷基，烷氧羰基烷基或(四氢-2H-吡喃-2-氧基)烷基，烷基和烷氧基基团含有1至5个碳原子，R.sub.4是氢或C.sub.1 -C.sub.4 -烷基，R.sub.5是氢，C.sub.1 -C.sub.4 -烷基或苯基，R.sub.7是氢，卤素或C.sub.1 -C.sub.4 -烷氧基，R.sub.8是氢，卤素或C.sub.1 -C.sub.4 -烷基，R.sub.1至R.sub.8中至少一个符号不是氢，其制备方法和含有相同的药物组合物。特别地，本发明的化合物在治疗记忆障碍方面是有用的。

  公开号：

  US04080449A1

文献信息

• Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine
  申请人：Sterling Drug Inc.

  公开号：US05098901A1

  公开（公告）日：1992-03-24

  Novel imidazo[1,2-b][2]benzazepines and pyrimido[1,2-b][2]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmias in mammals utilizing them, and processes for synthesizing them. ##STR1##

  新型咪唑并[1,2-b][2]苯并蒽啉和嘧啶并[1,2-b][2]苯并蒽啉的化学式I，含有它们的药物组合物，利用它们治疗哺乳动物心律失常的方法，以及它们的合成过程。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Thorsett D. Eugene

  公开号：US20070203108A1

  公开（公告）日：2007-08-30

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及抑制β-淀粉样肽的释放和/或合成的化合物，因此在治疗阿尔茨海默病方面具有用途。同时，本发明还涉及包含抑制β-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这些药物组合物预防和治疗阿尔茨海默病的方法。
• The triflic acid-mediated cyclisation of N-benzylcinnamanilides
  作者：Frank D. King、Stephen Caddick

  DOI：10.1016/j.tet.2013.07.075

  日期：2013.10

  N-Benzylcinnamanilides cyclise with triflic acid to form 1-benzyl-4-aryl-2,4-dihydro-1H-quinolin-2-ones and 2,5-diaryl-benzazepin-3-ones. The product ratio is determined by the preferred orientation of the amide and by the electronics of the substituents. With ortho-substituted anilides, N-debenzylation also occurs to give 4-aryl-2,4-dihydro-1H-quinoline-2-ones. (C) 2013 Elsevier Ltd. All rights reserved.
• The triflic acid-mediated cyclisation of N-benzyl-cinnamamides
  作者：Frank D. King、Stephen Caddick

  DOI：10.1016/j.tet.2012.11.035

  日期：2013.1

  N-Benzyl-cinnamamides cyclise with triflic acid to form 5-aryl-benzazepinones and/or cinnamamides. (c) 2012 Elsevier Ltd. All rights reserved.
• Synthesis of novel tetrahydrobenzazepinones
  作者：Carl A. Busacca、Robert E. Johnson

  DOI：10.1016/0040-4039(92)88040-c

  日期：1992.1

  The synthesis of novel tetrahydrobenzazepinones 1, 2, and 3 is described, as well as an improved synthesis of 4. The palladium catalyzed arylation approach to 1, 2, and 4 allows facile entry to benzazepinones lacking electron donating substituents on the benzo ring.