苯磺酰胺,4-甲基-N-4-吡啶基- | 15309-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯磺酰胺,4-甲基-N-4-吡啶基-
• 英文名称: N-(4-pyridyl)-p-toluenesulfonamide
• 英文别名: N-pyrid-4-yl-p-toluenesulfonamide；N-tosyl-4-aminopyridine；N-pyridin-4-yl-toluene-4-sulfonamide；N-[4]pyridyl-toluene-4-sulfonamide；N-[4]Pyridyl-toluol-4-sulfonamid；4-methyl-N-pyridin-4-ylbenzenesulfonamide
• CAS: 15309-69-0
• 化学式: C₁₂H₁₂N₂O₂S
• mdl: MFCD00545381
• 分子量: 248.305
• InChiKey: XAICNOASCGJHSS-UHFFFAOYSA-N

物化性质

• 熔点：
  305 °C(Solv: ethanol (64-17-5))
• 沸点：
  415.0±47.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯磺酰胺,4-甲基-N-4-吡啶基- 在 盐酸 作用下， 反应 10.0h， 以0.1 g的产率得到4-氨基吡啶
  参考文献：
  名称：

  摘要：

  In reaction of quinoline N-oxide with 2-aminopyridine in the presence of tosyl chloride the substrate undergoes reductive amination into 2-pyridyl(2-quinolyl)an-line, and with 3- and 4-aminopyridines reductive tosylamination occurs to furnish N-tosyl derivatives of the corresponding 3- and 4-pyridyl(2-quinolyl)amines. N-tosyl derivatives of aminopyridines also react along reductive tosylamination pathway.

  DOI：

  10.1023/a:1020913929185
• 作为产物：
  描述：

  4-bis(p-tolylsulfonyl)aminopyridine 以 乙醇 为溶剂， 反应 5.0h， 以67%的产率得到苯磺酰胺,4-甲基-N-4-吡啶基-
  参考文献：
  名称：

  摘要：

  In reaction of quinoline N-oxide with 2-aminopyridine in the presence of tosyl chloride the substrate undergoes reductive amination into 2-pyridyl(2-quinolyl)an-line, and with 3- and 4-aminopyridines reductive tosylamination occurs to furnish N-tosyl derivatives of the corresponding 3- and 4-pyridyl(2-quinolyl)amines. N-tosyl derivatives of aminopyridines also react along reductive tosylamination pathway.

  DOI：

  10.1023/a:1020913929185

文献信息

• Pyridinyl Amide Ion Pairs as Lewis Base Organocatalysts
  作者：Julian Helberg、Torsten Ampßler、Hendrik Zipse

  DOI：10.1021/acs.joc.0c00114

  日期：2020.4.17

  Pyridinyl amide ion pairs carrying various electron-withdrawing substituents were synthesized with selected ammonium or phosphonium counterions. Compared to neutral pyridine-based organocatalysts, these new ion pair Lewis bases display superior catalytic reactivity in the reaction of isocyanates with alcohols and the aza-Morita–Baylis–Hillman reaction of hindered electrophiles. The high catalytic activity

  带有各种吸电子取代基的吡啶基酰胺离子对与选定的铵或phospho抗衡离子合成。与中性吡啶基有机催化剂相比，这些新型离子对Lewis碱在异氰酸酯与醇的反应以及受阻亲电试剂的aza -Morita-Baylis-Hillman反应中显示出优异的催化反应性。离子对催化剂的高催化活性似乎是由于它们对中性亲电试剂的高Lewis碱度，这是通过量子化学计算的亲和力数据定量得出的。
• Reductive Acylamination of Pyridine N-Oxide with Aminopyridines and Their N-p-Tolylsulfonyl Derivatives
  作者：M. A. Solekhova、Yu. V. Kurbatov

  DOI：10.1007/s11178-005-0134-x

  日期：2005.1

  Pyridine N-oxide reacts with 2- and 3-aminopyridines and their N-p-tolylsulfonyl derivatives in alkaline medium in the presence of p-toluenesulfonyl chloride to give N-p-tolylsulfonyl-2,2′- and 2,3′-dipyridylamines, respectively, as a result of reductive acylamination. In the reactions with 4-aminopyridine and 4-p-tolylsulfonyl-aminopyridine, their N-p-tolylsulfonyl- and N,N-bis(p-tolylsulfonyl) derivatives are formed, while reductive acylamination does not occur.

  N-氧化吡啶与2-和3-氨基吡啶及其N-对甲苯磺酰基衍生物在碱性介质中在对甲苯磺酰氯存在下反应，分别生成N-对甲苯磺酰基-2,2'-和2,3'-联吡啶胺，作为还原酰胺化的结果。在与4-氨基吡啶和4-对甲苯磺酰氨基吡啶的反应中，形成它们的N-对甲苯磺酰基和N,N-双(对甲苯磺酰基)衍生物，但不发生还原酰胺化。
• 6-AMINOISOQUINOLINE COMPOUNDS
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US20130137721A1

  公开（公告）日：2013-05-30

  6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

  提供了影响、抑制或减少激酶作用的6-氨基异喹啉化合物。还提供了包括治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的制药组合物。还提供了使用这些化合物和/或组合物影响癌症、肥胖症和青光眼等疾病状态或病情的各种方法。
• Grammaticakis, Bulletin de la Societe Chimique de France, 1959, p. 480,491
  作者：Grammaticakis

  DOI：——

  日期：——
• Savelova; Zubareva; Simanenko, Russian Journal of Organic Chemistry, 1996, vol. 32, # 10, p. 1495 - 1500
  作者：Savelova、Zubareva、Simanenko

  DOI：——

  日期：——