4-氨基-5-(羧甲基氨基)-5-氧代-戊酸 | 13716-89-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-氨基-5-(羧甲基氨基)-5-氧代-戊酸
• 英文名称: Glu-Gly
• 英文别名: H-Glu-Gly-OH；(4S)-4-amino-5-(carboxymethylamino)-5-oxopentanoic acid
• CAS: 13716-89-7
• 化学式: C₇H₁₂N₂O₅
• 分子量: 204.183
• InChiKey: LSPKYLAFTPBWIL-BYPYZUCNSA-N

物化性质

• 熔点：
  175-176 °C
• 沸点：
  589.0±50.0 °C(Predicted)
• 密度：
  1.424±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2924199090
• 储存条件：
  2-8°C，干燥

反应信息

• 作为反应物：
  描述：

  4-氨基-5-(羧甲基氨基)-5-氧代-戊酸 在 soybean cotyledon N-terminal acidic amino acid-specific aminopeptidase 作用下， 生成 L-谷氨酸 、 聚甘氨酸
  参考文献：
  名称：

  Purification and Characterization of an N-Terminal Acidic Amino Acid-Specific Aminopeptidase from Soybean Cotyledons (Glycine max)

  摘要：

  通过硫酸铵分级和 Q-sepharose、Phenyl sepharose 和 Superdex 200 连续柱层析，从大豆子叶中分离出一种催化 Glu-Glu 高效水解的新型酶。该酶的表观分子量为 56 kDa分别通过 SDS-聚丙烯酰胺凝胶电泳和 Superdex 200 HR 10/30 柱层析得出 510 kDa 和 510 kDa。该酶对 Glu-p-硝基苯胺 (pNA) 和 Asp-pNA 具有高活性，而 Leu-pNA、Phe-pNA、Ala-pNA 和 Pro-pNA 不被水解。合成的二肽 Glu-Xxx 和 Asp-Xxx 被水解，但 Xxx-Glu 没有被水解。使用这种纯化酶消化富含 Glu 的寡肽嗜铬粒蛋白 A (Glu-Glu-Glu-Glu-Glu-Met-Ala-Val-Val-Pro-Gln-Gly-Leu-Phe-Arg-Gly-NH2)也被调查。谷氨酸残基从N末端一一被切割。这些观察结果表明该酶从 N 末端含酸性氨基酸的肽中去除谷氨酰或天冬氨酰残基。人们认为它是一种来自植物的 N 末端酸性氨基酸特异性氨肽酶。

  DOI：

  10.1271/bbb.90617
• 作为产物：
  描述：

  5-oxo-1-(toluene-4-sulfonyl)-L-prolyl chloride 在 sodium hydroxide 、 palladium on activated charcoal 、 乙醇 、 氯仿 、 氨 、 水 、 sodium 、 碳酸氢钠 、 溶剂黄146 作用下， 生成 4-氨基-5-(羧甲基氨基)-5-氧代-戊酸
  参考文献：
  名称：

  Rudinger, Collection of Czechoslovak Chemical Communications, 1954, vol. 19, p. 365,373

  摘要：

  DOI：

文献信息

• Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides
  作者：Chen-Yu Chien、Sheng-Sheng Yu

  DOI：10.1039/d0cc03319g

  日期：——

  ester–amide exchange reaction enables spontaneous formation of prebiotic proto-peptides under mild conditions. However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages. Here, we demonstrate using deep eutectic solvents as a universal strategy to regulate the reaction pathways and promote the formation of amino acid-enriched oligomers with peptide backbones

  酯-酰胺交换反应可在温和条件下自发形成益生元原肽。但是，该反应还导致酯和酰胺键的序列差异很大的低聚物。在这里，我们证明了使用深共晶溶剂作为调节反应途径和促进带有肽主链的富含氨基酸的低聚物形成的通用策略。
• Depth-sensing indentation at macroscopic dimensions
  作者：Jeremy Thurn、Dylan J. Morris、Robert F. Cook

  DOI：10.1557/jmr.2002.0388

  日期：2002.10

  A macroscopic-scale depth-sensing indentation apparatus with the ability to be mounted on an inverted microscope for in situ observation of contact events was calibrated using the Oliver and Pharr [J. Mater. Res. 7, 1564 (1992)] procedure with a two-parameter area function. The calibrated Vickers tip was used to determine the projected contact area at peak load and the modulus and hardness of a variety of non-metallic materials through deconvolution of the measured load-displacement traces. The predicted contact area was found to be identical to the measured area of residual contact impressions. Furthermore, for transparent ceramic materials the projected contact area during loading was found to be the same as the area measured from the diagonal of post-indentation residual contact impressions. The modulus and hardness values deconvoluted from the load–displacement traces were compared with independent measurements. The effects of sample clamping, column compliance, and tip radius on the load–displacement data and inferred materials properties were also examined. It is suggested that the simplicity of instrumentation and operation, combined with the ability to observe indentations optically, even in situ, makes macroscopic-scale depth-sensing indentation ideal for fundamental studies of contact mechanics.

  使用 Oliver 和 Pharr [J. Mater. Res. 7, 1564 (1992)]的双参数面积函数程序校准了可安装在倒置显微镜上现场观察接触事件的宏观尺度深度感应压痕仪。校准后的维氏针尖用于确定峰值载荷时的预计接触面积，以及通过对测量的载荷-位移轨迹进行解卷积来确定各种非金属材料的模量和硬度。结果发现，预测的接触面积与测量的残留接触印痕面积相同。此外，对于透明陶瓷材料，加载期间的预测接触面积与压痕后残留接触印痕对角线上测量的面积相同。从加载-位移轨迹中分解出的模量和硬度值与独立测量值进行了比较。此外，还研究了样品夹持、柱顺应性和顶端半径对载荷-位移数据和推断材料属性的影响。研究表明，仪器和操作的简易性，加上光学观测压痕的能力，甚至是原位观测的能力，使宏观尺度的深度感应压痕成为接触力学基础研究的理想选择。
• Polypeptides. Part XIV. The synthesis of some oligopeptides containing lysine and glutamic acid residues
  作者：A. T. Moore、H. N. Rydon、M. J. Smithers

  DOI：10.1039/j39660002349

  日期：——

  the great lability of side-chain benzyl ester groups towards alkali. Finally, four protected oligopeptides of the required type were synthesised, using benzyloxycarbonyl for α-N-protection, t-butyl ester for ω-C-protection, and trifluoroacetyl and methyl ester for the protection of lysine and glutamic acid side-chains, respectively. Three of these were converted into side-chain protected peptides suitable

  已经合成了几种通式为A- Ly [省略图形]。（或[省略图形] lu）.Gly n。[图形省略] lu。（或[y省略图形] ys）.Gly n .O B的寡肽；它们用于聚合实验和“加倍”的预期用途对可以使用的保护基施加了限制，因为这些保护基必须可以选择性地除去。在两种情况下，无法删除N-甲酰基基团而不会破坏肽键，而在这些以及另外的情况下，侧链苄基酯基团对碱的不稳定性极大地阻止了其他保护基团的选择性去除。最后，合成了四种所需类型的被保护的寡肽，分别使用苄氧基羰基用于α - N保护，叔丁酯用于ω- C保护以及三氟乙酰基和甲酯用于保护赖氨酸和谷氨酸侧链。 。通过“加倍”方法将其中的三个转变为适合聚合的侧链保护肽，然后转变为游离肽，其中两个转变为八肽和十二肽。
• REMEDIES FOR BRAIN DISEASES
  申请人：WAKUNAGA PHARMACEUTICAL CO., LTD.

  公开号：EP0885608A1

  公开（公告）日：1998-12-23

  The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1):         CH2=CH-CH2-S(O)n-R     (1) [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl group, a substituted alkenyl group, an alkylthio group, an alkenylthio group, a phenyl group, a substituted phenyl group, a heterocyclic group, or a group derived from an amino acid or an oligopeptide by deletion of one hydrogen atom, and which group may have a protective group; and n is 0, 1, or 2], a glycoside thereof, or a salt of the compound or the glycoside. The drug of the present invention for ameliorating brain diseases, inhibiting reduction of brain neurons and promoting branching of neurites, is useful for the prevention and treatment of brain diseases such as dementia in association with degeneration and sloughing of brain neurons.

  本发明公开了式 (1) 所代表的化合物在制造脑疾病预防和治疗药物中的用途： CH2=CH-CH2-S(O)n-R (1) [其中 R 代表氢原子、烷基、烯基、取代的烷基、取代的烯基、烷硫基、烯硫基、苯基、取代的苯基、杂环基、或由氨基酸或低聚肽去掉一个氢原子衍生的基团，该基团可带有保护基；且 n 为 0、1 或 2]、其糖苷或该化合物或该糖苷的盐。 本发明用于改善脑部疾病、抑制脑神经元减少和促进神经元分支的药物可用于预防和治疗与脑神经元变性和脱落有关的痴呆等脑部疾病。
• Fixation of nucleotide derivatives to solid carrier
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1098004A2

  公开（公告）日：2001-05-09

  A DNA chip or its analogue composed of nucleotide derivatives attached to a solid carrier is prepared by method of bringing nucleotide derivatives having a reactive group at each one terminal into contact with a solid carrier having thereon reactive groups in an aqueous phase in the presence of a transferase which is capable of producing a covalent bond by rearrangement of the reactive group of the nucleotide derivative and the reactive group of the solid carrier.

  DNA 芯片或其类似物由附着在固体载体上的核苷酸衍生物组成，其制备方法是：在水相中，在转移酶的存在下，使每个末端都带有一个活性基团的核苷酸衍生物与带有活性基团的固体载体接触，这种转移酶能够通过核苷酸衍生物的活性基团和固体载体的活性基团的重排产生共价键。