1H,1H-七氟丁基三氟化物 | 6401-01-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 1H,1H-七氟丁基三氟化物
• 中文别名: 1H，1H-七氟丁基三氟甲磺酸酯
• 英文名称: 2,2,3,3,4,4,4-heptafluorobutyl trifluoromethanesulfonate
• CAS: 6401-01-0
• 化学式: C₅H₂F₁₀O₃S
• mdl: MFCD02093339
• 分子量: 332.119
• InChiKey: NFLLLSBGBGDVEO-UHFFFAOYSA-N

物化性质

• 沸点：
  118-120/732mm

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  13

安全信息

• 危险等级：
  TOXIC, CORROSIVE
• 危险品标志：
  T,C
• 海关编码：
  2905590090

反应信息

• 作为反应物：
  描述：

  对硝基苯酚 、 1H,1H-七氟丁基三氟化物 在 sodium hydride 作用下， 以 六甲基磷酰三胺 为溶剂， 以85%的产率得到4-nitro-1-(2,2,3,3,4,4,4-heptafluorobutoxy)benzene
  参考文献：
  名称：

  Various synthetic approaches to fluoroalkyl p-nitrophenyl ethers

  摘要：

  Homologous 1H,1H-perfluoroalkyl p-nitrophenyl ethers (alkyl = C-2-C-8) were synthesized using different methods. The results are discussed in context with contradictory comments of the literature. The fluoroalkoxylation of p-chloronitrobenzene occurs in only one step, but it is limited to small fluoroalkyl groups. The fluoroalkylation of p-nitrophenol via sulphonic acid esters is a better synthetic route. Differences in reactivity and yield between tosylates, mesylates and triflates are found and discussed. The preferred synthesis includes the use of trifluoromethane sulphonic acid esters.

  DOI：

  10.1016/s0022-1139(96)03490-2
• 作为产物：
  描述：

  [2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl(phenyl)-λ3-iodanyl] trifluoromethanesulfonate 以90%的产率得到
  参考文献：
  名称：

  UMEMOTO, TERUO;GOTOH, YOSHIHIKO, BULL. CHEM. SOC. JAP., 60,(1987) N 9, 3307-3313

  摘要：

  DOI：
• 作为试剂：
  描述：

  2,2,3,3,4,4,4-七氟-1-碘丁烷 、 2-[3-bromo-2-(hydroxy)phenoxy]-5-chloropyrimidine 在 1H,1H-七氟丁基三氟化物 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以45 mg的产率得到2-[3-bromo-2-(2,2,3,3,4,4,4-heptafluorobutoxy)phenoxy]-5-chloropyrimidine
  参考文献：
  名称：

  [EN] ARYLOXYPYRIMIDINYL ETHERS AS HERBICIDES
  [FR] ÉTHERS D'ARYLOXYPYRIMIDINYLE EMPLOYÉS COMME HERBICIDES

  摘要：

  本文披露了Formula 1的化合物，包括所有立体异构体、N-氧化物和盐类，其中A、R1、R2和R3如披露中所定义。还披露了含有Formula 1化合物的组合物，以及用于控制不受欢迎的植被的方法，包括将不受欢迎的植被或其环境与本发明的化合物或组合物的有效量接触。

  公开号：

  WO2017011288A1

文献信息

• [EN] NITRILE COMPOUND AND ITS USE IN PEST CONTROL<br/>[FR] COMPOSE NITRILE ET SON UTILISATION POUR LE CONTROLE DES INSECTES ET ANIMAUX NUISIBLES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2005063694A1

  公开（公告）日：2005-07-14

  The present invention provides a nitrile compound represented by the formula (I): wherein R represents C1-C4 fluoroalkyl, Q represents halogen, C1-C11 alkyl optionally substituted with halogen, C2-C6 alkenyl group optionally substituted with halogen, C2-C6 alkynyl optionally substituted with halogen, C3-C7 cycloalkyl optionally substituted with halogen or (C3-C7 cycloalkyl optionally substituted with halogen)C1-C4 alkyl, which has excellent control effect against pests.

  本发明提供了一种由式(I)表示的腈化合物：其中R代表C1-C4氟烷基，Q代表卤素，C1-C11烷基可选择地取代卤素，C2-C6烯基基团可选择地取代卤素，C2-C6炔基可选择地取代卤素，C3-C7环烷基可选择地取代卤素或(C3-C7环烷基可选择地取代卤素)C1-C4烷基，对害虫具有出色的控制效果。
• [EN] 1,3,4-OXADIAZOLE HOMOPHTHALIMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] COMPOSÉS DÉRIVÉS DE 1,3,4-OXADIAZOLE HOMOPHTALIMIDE UTILISÉS COMME INHIBITEUR DE L'HISTONE DÉSACÉTYLASE 6, ET COMPOSITION PHARMACEUTIQUE LES COMPRENANT
  申请人：CHONG KUN DANG PHARMACEUTICAL CORP

  公开号：WO2020240493A1

  公开（公告）日：2020-12-03

  The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

  本发明涉及具有组蛋白去乙酰化酶6（HDAC6）抑制活性的新化合物，其立体异构体或其药学上可接受的盐，其药用用途以及其制备方法。根据本发明的新化合物，其立体异构体或其药学上可接受的盐具有组蛋白去乙酰化酶6（HDAC6）抑制活性，并且在预防或治疗与HDAC6相关的疾病方面具有有效性，包括传染病；肿瘤；内分泌病；营养和代谢疾病；精神和行为障碍；神经系统疾病；眼部和眼附器疾病；循环系统疾病；呼吸系统疾病；消化系统疾病；皮肤和皮下组织疾病；肌肉骨骼系统和结缔组织疾病；以及畸形或变形，或染色体异常。
• [EN] 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] COMPOSÉS DÉRIVÉS DE 1,3,4-OXADIAZOLE UTILISÉS COMME INHIBITEURS D'HISTONE DÉSACÉTYLASE 6, ET COMPOSITION PHARMACEUTIQUE LES COMPRENANT
  申请人：CHONG KUN DANG PHARMACEUTICAL CORP

  公开号：WO2020240492A1

  公开（公告）日：2020-12-03

  The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

  本发明涉及具有组蛋白去乙酰化酶6（HDAC6）抑制活性的1,3,4-噁二唑衍生物化合物，其立体异构体或其药学上可接受的盐，以及其在药物制备中的用途，包括相同的药物组成、使用该组成的治疗方法，以及制备该组成的方法，其中1,3,4-噁二唑衍生物化合物由以下化学式（I）表示。
• Fluorine-containing chiral smectic liquid crystals
  申请人：Minnesota Mining and Manufacturing Company

  公开号：US05254747A1

  公开（公告）日：1993-10-19

  Compounds are provided which comprise a fluorocarbon terminal portion and a chiral hydrocarbon terminal portion, said terminal portions being connected by a central core, said compounds having tilted smectic mesophases or having latent tilted smectic mesophases which develop when said compounds having said latent mesophases are in admixture with said compounds having tilted smectic mesophases or said compounds having latent tilted smectic mesophases.

  提供的化合物包括氟碳末端部分和手性烃碳末端部分，这些末端部分通过中心核连接，这些化合物具有倾斜的薄层介相或具有潜在的倾斜薄层介相，当这些具有潜在倾斜薄层介相的化合物与具有倾斜薄层介相或具有潜在倾斜薄层介相的化合物混合时，这些化合物会产生。
• Achiral fluorine-containing liquid crystals
  申请人：——

  公开号：US05082587A1

  公开（公告）日：1992-01-21

  Achiral fluorine-containing liquid crystal compounds are provided. The compounds comprise a fluorocarbon terminal portion and a hydrocarbon or another fluorocarbon terminal portion, the terminal portions being connected by a central core, the compounds having smectic mesophases or having latent smectic mesophases. The compounds are useful in liquid crystal display devices both along and in mixtures with other materials. Also provided is a process for preparing these compounds.

  提供了不对映的含氟液晶化合物。这些化合物包括氟碳端部和烃基或另一氟碳端部，这些端部通过一个中心核心连接，这些化合物具有薄层介晶相或具有潜在的薄层介晶相。这些化合物在液晶显示器件中与其他材料一起使用时非常有用。还提供了制备这些化合物的方法。