3,3',4,4'-四氯二苯甲酮 | 75795-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,3',4,4'-四氯二苯甲酮
• 英文名称: 3,3',4,4'-tetrachlorobenzophenone
• 英文别名: 3,4,3',4'-tetrachloro-benzophenone；3,4,3',4'-Tetrachlor-benzophenon；3,4,3',4'-tetrachlorobenzophenone；3,4,3',4'-Tetrachlorbenzophenon；Bis(3,4-dichlorophenyl)methanone
• CAS: 75795-07-2
• 化学式: C₁₃H₆Cl₄O
• mdl: MFCD06201543
• 分子量: 320.002
• InChiKey: NFBPWLOFHJEKOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  3,3',4,4'-四氯二苯甲酮 在 RaNi 噻吩 、 盐酸羟胺 、 氨 、 氢气 、 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成 C,C-Bis-(3,4-dichloro-phenyl)-methylamine
  参考文献：
  名称：

  2-Mercaptoimidazoles, a new class of potent CCR2 antagonists

  摘要：

  We describe the synthesis and SAR of a new class of CCR2 antagonists based on a 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC50 values in the MCP-1 induced Ca-flux below 0.01 muM. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.064
• 作为产物：
  描述：

  邻二氯苯 在 四氯化碳 、 三氯化铝 作用下， 生成 3,3',4,4'-四氯二苯甲酮
  参考文献：
  名称：

  FRIEDEL AND CRAFTS REACTION. II. THE CONDENSATION OF ortho- AND meta- DICHLOROBENZENE WITH CHLOROFORM AND CARBON TETRACHLORIDE

  摘要：

  DOI：

  10.1021/jo01209a001

文献信息

• Phosphate compounds and their use as medicaments
  申请人：Astra Pharmaceuticals Ltd.

  公开号：US05985849A1

  公开（公告）日：1999-11-16

  A compound of the formula (I) or salts thereof: ##STR1## wherein X, R.sup.1, Q.sup.1 and Q.sup.2 are as defined in the specification. The compounds have been found to be P2 7-TM G-protein receptor antagonists, especially to the P2 Y2 receptor, and are useful in therapy, for example as anti-inflammatory agents useful in the treatment of a number of inflammatory diseases such as asthma, inflammatory bowel disease, ARDS, psoriasis, rheumatoid arthritis, myocardial ischaemia, COPD, cystic fibrosis, arthrosclerosis, restenosis, peridontal disease, septic shock, osteoarthritis and stroke.

  公式(I)的化合物或其盐：##STR1## 其中X，R 1，Q 1和Q 2如说明书中所定义。这些化合物被发现是P2 7-TM G蛋白受体拮抗剂，特别是P2 Y2受体拮抗剂，并且在治疗中有用，例如作为抗炎剂，可用于治疗多种炎症性疾病，如哮喘，炎症性肠病，ARDS，银屑病，类风湿性关节炎，心肌缺血，COPD，囊性纤维化，动脉硬化，再狭窄，牙周病，败血症性休克，骨关节炎和中风。
• Mechanical relaxations in heat-aged polycarbonate. Part II: Statistical analysis of low-molecular weight data
  作者：Donna Dykeman、Pearl Lee-Sullivan

  DOI：10.1002/pen.10032

  日期：2003.2

  The significance of heat-aging effects on low-molecular-weight polycarbonate has been studied by performing a two-factor Analysis of Variance (ANOVA). Although this work was primarily motivated by the large experimental scatter observed in stress relaxation results for LMW 2608 (part I), the effect of heat-aging on the characteristics of secondary transitions (γ and β1) generated by dynamic testing was also investigated. Both types of tests were performed using a dynamic mechanical analyzer. The statistical analysis verified an earlier suggestion that both the secondary transitions were insensitive to heat-aging. In the quasi-static stress relaxation tests, the curve-fitted KWW parameters (τ, Eo′ β′) were evaluated using ANOVA for increasing heat-aging time and test temperature. Two other statistical techniques were also applied to test repeatability—the power of each aging time/test temperature combination and the number of observations needed to achieve 90% repeatability. In conclusion, both τ and β′ could describe the self-retarding nature of volume recovery although the repeatability of β′ was substantially higher. However, the unrelaxed modulus, Eo, was found to be an unreliable indicator of whether heat-treatment had caused changes in the intrinsic structure. Overall, the study showed that the repeatability of the stress relaxation test results is generally very poor for the confidence levels tested.

  通过进行双因素方差分析（ANOVA），研究了热老化对低分子量聚碳酸酯影响的重要性。虽然这项工作的主要动机是在 LMW 2608（第一部分）的应力松弛结果中观察到较大的实验散差，但也研究了热老化对动态测试产生的二次转变（γ 和 β1）特性的影响。这两种测试都是使用动态机械分析仪进行的。统计分析验证了之前的观点，即二次转变对热老化不敏感。在准静态应力松弛试验中，使用方差分析评估了热老化时间和试验温度增加时的曲线拟合 KWW 参数（τ、Eo′ β′）。此外，还采用了另外两种统计技术来测试重复性--每种老化时间/测试温度组合的功率和达到 90% 重复性所需的观察次数。总之，τ 和 β′ 都能描述体积恢复的自回复性质，但 β′ 的重复性要高得多。不过，未松弛模量 Eo 被认为是热处理是否导致内在结构变化的不可靠指标。总之，研究表明，在所测试的置信水平下，应力松弛测试结果的可重复性通常很差。
• Method of making halobenzophenones and intermediates thereof
  申请人：Occidental Chemical Corporation

  公开号：US04978798A1

  公开（公告）日：1990-12-18

  Disclosed is a method of making a bisphenyl dihalomethane by reacting a trihalomethylbenzene with a halobenzene and a Lewis acid. The bisphenyl dihalomethane can than be reacted with water to form a halobenzophenone. In an optical third step ring chlorines that are present can be replaced with fluorines and, in a final step, any remaining chlorines can be removed to leave a fluorobenzophenone. The process is particularly useful in making 4,4'-difluorobenzophenone, which is in turn useful in making polyetheretherketones.

  本发明涉及一种制备双酚二卤甲烷的方法，该方法通过将三卤甲基苯与卤代苯和路易斯酸反应来实现。然后，可以将双酚二卤甲烷与水反应，形成卤代苯酮。在第三步中，可以用氟代素取代存在的环状氯元素，在最后一步中，可以去除任何剩余的氯元素，以留下氟代苯酮。该过程在制备4,4'-二氟苯酮方面特别有用，而4,4'-二氟苯酮又可用于制备聚醚醚酮。
• [EN] NOVEL PHOSPHATE COMPOUNDS AND THEIR USE AS MEDICAMENTS<br/>[FR] NOUVEAUX COMPOSES DE PHOSPHATE ET LEUT UTILISATION COMME MEDICAMENTS
  申请人：ASTRA PHARMACEUTICALS LTD.

  公开号：WO1998045309A1

  公开（公告）日：1998-10-15

  (EN) The invention provides novel phosphate derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory conditions.(FR) L'invention concerne de nouveaux dérivés de phosphate, leurs procédés de préparation, des compositions pharmaceutiques les contenant et leur utilisation pour le traitement d'états inflammatoires.

  该发明提供了新型磷酸盐衍生物，其制备方法，包含它们的药物组合物以及它们在治疗炎症状况方面的应用。
• Ketones
  申请人：Barton John Peter

  公开号：US20050272036A1

  公开（公告）日：2005-12-08

  Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  描述了式(I)的化合物：其中变量基团如定义的那样；用于抑制11βHSD1。