1H-3-苯并吖庚英-1-醇,2,3,4,5-四氢-7,8-二甲氧基- | 14165-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 中文名称: 1H-3-苯并吖庚英-1-醇,2,3,4,5-四氢-7,8-二甲氧基-
• 英文名称: 7,8-Dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
• 英文别名: 1H-1-Hydroxy-7,8-dimethoxy-2,3,4,5-tetrahydro-benzazepin-3；1-Hydroxy-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin；1H-7,8-Dimethoxy-2,3,4,5-tetrahydro-benzazepin-3-ol-1；1-hydroxy-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine；7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol；7,8-dimethoxy-1-hydroxy-2,3,4,5-tetrahydro-3-benzazepine；7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-5-ol
• CAS: 14165-92-5
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: DLBVOUHTERRKRW-UHFFFAOYSA-N

物化性质

• 熔点：
  161 °C
• 沸点：
  396.0±42.0 °C(Predicted)
• 密度：
  1.144±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1H-3-苯并吖庚英-1-醇,2,3,4,5-四氢-7,8-二甲氧基- 在 manganese(IV) oxide 、 sodium tetrahydroborate 、 sodium periodate 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 36.0h， 生成 2-甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉-1-酮
  参考文献：
  名称：

  Moehrle; Rohn; Westle, Pharmazie, 2006, vol. 61, # 5, p. 391 - 399

  摘要：

  DOI：
• 作为产物：
  描述：

  7,8-Dimethoxy-2,3,4,5-tetrahydro-3-tosyl-1H-3-benzazepin-1-ol 在 sodium 作用下， 以 氨 为溶剂， 以78%的产率得到1H-3-苯并吖庚英-1-醇,2,3,4,5-四氢-7,8-二甲氧基-
  参考文献：
  名称：

  Moehrle; Rohn; Westle, Pharmazie, 2006, vol. 61, # 5, p. 391 - 399

  摘要：

  DOI：

文献信息

• 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04794181A1

  公开（公告）日：1988-12-27

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same of different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.

  该发明涉及式中Y为相同或不同的氢和较低的烷氧基；X为氢、卤素、较低的烷基、较低的烷氧基、三氟甲基、硝基、氰基和氨基；R为氢、较低的烷基、环烷基较低的烷基、Ar较低的烷基；其中Z为氢、较低的烷基、较低的烷氧基、卤素、三氟甲基、硝基和氨基；Aryloxy较低的烷基；以及药学上可接受的酸盐。
• 2,3,4,5-Tetrahydro-1H-3-benzazepine-7,8-diones
  申请人：SmithKline Corporation

  公开号：US04108989A1

  公开（公告）日：1978-08-22

  Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.

  新型苯并哌啶衍生物具有中枢和外周多巴胺活性，可用于治疗帕金森病和心血管疾病。这些化合物还可用作合成具有类似有用性质的其他苯并哌啶的中间体。其中1-苯基-2,3,4,5-四氢-1H-3-苯并哌啶-7,8-二酮衍生物特别有用。
• Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  申请人：SmithKline Corporation

  公开号：US04111957A1

  公开（公告）日：1978-09-05

  A group of 7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines with structures containing a thienyl or furyl ring at position 1 which have dopaminergic activity. Particular species of this group include 7,8-dihydroxy-1-(5'-methyl-2'-thienyl)-2,3,4,5-tetrahydro-1H-3-benzazepine and its dimethyl ether derivative, 7,8-dihydroxy-1-(2'-thienyl)-2,3,4,5-tetrahydro-1H-3-benzazepine and its dimethyl ether as well as 7,8-dihydroxy-1-(3'-thienyl)-2,3,4,5-tetrahydro-1H-3-benzazepine and its dimethyl ether.

  一组结构中含有噻吩或呋喃环在位置1的7,8-二羟基-2,3,4,5-四氢-1H-3-苯并吖啶类化合物，具有多巴胺活性。该组中特定物种包括7,8-二羟基-1-(5'-甲基-2'-噻吩基)-2,3,4,5-四氢-1H-3-苯并吖啶及其二甲醚衍生物，7,8-二羟基-1-(2'-噻吩基)-2,3,4,5-四氢-1H-3-苯并吖啶及其二甲醚，以及7,8-二羟基-1-(3'-噻吩基)-2,3,4,5-四氢-1H-3-苯并吖啶及其二甲醚。
• Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04935418A1

  公开（公告）日：1990-06-19

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.

  本发明涉及式子##STR1##中的1-芳氧基-2,3,4,5-四氢-3-苯并哌啶；其中Y相同或不同，是氢和低级烷氧基；X是氢、卤素、低级烷基、低级烷氧基、CF.sub.3、NO.sub.2、CN和NH.sub.2；R是氢、低级烷基、环烷基低级烷基、##STR2## Ar低级烷基的式子##STR3##其中Z是氢、低级烷基、低级烷氧基、卤素CF.sub.3、NO.sub.2和NH.sub.2；芳氧基低级烷基的式子##STR4##其中Z如前所述；以及式子##STR5##中的烷基胺，其中R.sub.1和R.sub.2相同或不同，是氢和低级烷基，n是1或2的整数；以及其药学上可接受的酸盐。
• 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0096838A1

  公开（公告）日：1983-12-28

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3- benzazepines of the formula wherein Y, and Y2 are the same or different and are hydrogen or lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF3, NO2, CN and NH2; R is hydrogen, lower alkyl, cycloatkyllower alkyl Ar lower alkyl of the formula -alkylene where Z is hydrogen, lower alkyl, lower alkoxy, halogen, CF3, NO2; and NH2; and an alkylene amine of the formula -alkylene where R, and R2 are the same or different and are hydrogen and lower alkyl and the alkylene moiety is of 1 to 6 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof.

  本发明涉及 1-芳氧基-2,3,4,5-四氢-3-苯并氮杂卓，其式为 其中 Y 和 Y2 是相同或不同的，并且是氢或低级烷氧基；X 是氢、卤素、低级烷基、低级烷氧基、CF3、NO2、CN 和 NH2；R 是氢、低级烷基、环烷基低级烷基 Ar 式中的低级烷基-亚烷基 其中 Z 是氢、低级烷基、低级烷氧基、卤素、CF3、NO2 和 NH2；以及式 - 烷基胺 其中 R 和 R2 相同或不同，且为氢和低级烷基，亚烷基为 1 至 6 个碳原子，以及它们的药学上可接受的酸加成盐。