(S)-(-)-2-ethoxycarbonylamino-1-phenylpropane | 26343-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(-)-2-ethoxycarbonylamino-1-phenylpropane
• 英文别名: (S)-2-((ethoxycarbonyl)amino)-1-phenylpropane；((S)-1-methyl-2-phenyl-ethyl)-carbamic acid ethyl ester；((S)-1-Methyl-2-phenyl-aethyl)-carbamidsaeure-aethylester；ethyl N-[(2S)-1-phenylpropan-2-yl]carbamate
• CAS: 26343-76-0
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: ZLJPEGDLROEOBC-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-(-)-2-ethoxycarbonylamino-1-phenylpropane 在 PPA 作用下， 以93%的产率得到(S)-(+)-3-甲基-1,2,3,4-四氢异喹啉-1-酮
  参考文献：
  名称：

  Diener, Wolfgang; Frelek, Jadwiga; Snatzke, Guenther, Collection of Czechoslovak Chemical Communications, 1991, vol. 56, # 5, p. 954 - 965

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl (S)-N-formyl(1-phenylpropan-2-yl)carbamate 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以98%的产率得到(S)-(-)-2-ethoxycarbonylamino-1-phenylpropane
  参考文献：
  名称：

  Radical 1,4-aryl transfer in arylcarboxamides leading to phthalimides, biaryls and enantiomerically enriched β-arylethylamines

  摘要：

  5-exo Cyclisation of vinyl-, aryl- and alkyl-radicals onto the aryl group of arylcarboxamides is followed by beta-scission of the resulting spirocyclohexadienyl radicals with ejection of a carbamoyl radical. The fate of this radical depends on the substrate but, in the cases studied, either 5-endo cyclisation or direct reduction follows to give phthalimides, biaryls or beta-arylethylamines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.118

文献信息

• D-AMPHETAMINE COMPOUNDS, COMPOSITIONS, AND PROCESSES FOR MAKING AND USING THE SAME
  申请人：KemPharm, Inc.

  公开号：US20200131130A1

  公开（公告）日：2020-04-30

  Disclosed are d-amphetamine compounds and compositions comprising at least one organic acid covalently bound to d-amphetamine, a salt thereof, a derivative thereof, or a combination thereof. Methods of making and using the same are also disclosed.

  揭示了d-安非他明化合物和组合物，其中至少有一种有机酸以共价键结合到d-安非他明，其盐，衍生物或其组合物。还公开了制备和使用这些化合物的方法。
• D-amphetamine compounds, compositions, and processes for making and using the same
  申请人：KemPharm, Inc.

  公开号：US11136295B2

  公开（公告）日：2021-10-05

  Disclosed are d-amphetamine compounds and compositions comprising at least one organic acid covalently bound to d-amphetamine, a salt thereof, a derivative thereof, or a combination thereof. Methods of making and using the same are also disclosed.

  公开了 d-安非他明化合物和组合物，其中包含至少一种与 d-安非他明共价结合的有机酸、其盐、其衍生物或其组合。还公开了制造和使用这些物质的方法。
• Analeptic Oxazolidinediones and Related Compounds
  作者：Seymour L. Shapiro、Ira M. Rose、Frank C. Testa、Louis Freedman

  DOI：10.1021/ja01530a031

  日期：1959.11
• .alpha.-Amino acids as chiral educts for asymmetric products. Amino acylation with N-acylamino acids
  作者：Thomas F. Buckley、Henry Rapoport

  DOI：10.1021/ja00410a030

  日期：1981.10
• Radical 1,4-aryl transfer in arylcarboxamides leading to phthalimides, biaryls and enantiomerically enriched β-arylethylamines
  作者：Jeremy Robertson、Matthew J. Palframan、Stephen A. Shea、Kirill Tchabanenko、William P. Unsworth、Chase Winters

  DOI：10.1016/j.tet.2008.07.118

  日期：2008.12

  5-exo Cyclisation of vinyl-, aryl- and alkyl-radicals onto the aryl group of arylcarboxamides is followed by beta-scission of the resulting spirocyclohexadienyl radicals with ejection of a carbamoyl radical. The fate of this radical depends on the substrate but, in the cases studied, either 5-endo cyclisation or direct reduction follows to give phthalimides, biaryls or beta-arylethylamines. (C) 2008 Elsevier Ltd. All rights reserved.