N-(tert-butoxycarbonyl)-O-(benzyloxycarbonyl)hydroxylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(tert-butoxycarbonyl)-O-(benzyloxycarbonyl)hydroxylamine
• 英文别名: N-(t-butoxycarbonyl)-O-(benzyloxycarbonyl)hydroxylamine；benzyl [(2-methylpropan-2-yl)oxycarbonylamino] carbonate
• 化学式: C₁₃H₁₇NO₅
• 分子量: 267.282
• InChiKey: PPZCKCKIDDWSIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(tert-butoxycarbonyl)-O-(benzyloxycarbonyl)hydroxylamine 在 palladium on activated charcoal 偶氮二甲酸二叔丁酯 、 氢气 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 5'-deoxy-5'-N-(N-tert-butoxycarbonyl)hydroxylaminoadenosine
  参考文献：
  名称：

  Syntheses of 5‘-Deoxy-5‘-N-hydroxylaminopyrimidine and Purine Nucleosides:  Building Blocks for Novel Antisense Oligonucleosides with Hydroxamate Linkages

  摘要：

  DOI：

  10.1021/jo991153b

文献信息

• Sulfonyl Hydrazine as New Functionality in Organocatalysis: Camphor­sulfonyl Hydrazine Catalyzed Enantioselective Aza-Michael Addition
  作者：Albert Lee、Ling-Yan Chen、Hao He、Bao-Jian Pei、Wing-Hong Chan

  DOI：10.1055/s-0029-1216639

  日期：——

  Sulfonyl hydrazine is a new functionality for the Lewis base organocatalysis. Nα-substituted camphorsulfonyl hydrazines (CaSH) are effective organocatalysts for the asymmetric aza-Michael addition to α,β-unsaturated aldehydes with enantioselectivity of up to 90%.

  磺酰肼是一种新的路易斯碱有机催化剂功能团。Nα-取代的樟脑磺酰肼（CaSH）是对α,β-不饱和醛进行不对称酰基-迈克尔加成的有效有机催化剂，具有高达90%的对映选择性。
• Syntheses of novel hydroxylamine carbanucleosides
  作者：Mark J. Mulvihill、Marvin J. Miller

  DOI：10.1016/s0040-4020(98)00359-7

  日期：1998.6

  Enantiomerically pure 4'-hydroxylamino-adenine-derived carbanucleosides have been synthesized as isosteric 4'-hydroxymethyl analogs to carbovir, ddA, and aristeromycin. The key steps in the syntheses involved an enzymatic desymmetrization, two subsequent Mitsunobu reactions, and a highly diastereoselective ruthenium tetroxide-mediated dihydroxylation, overcoming the syn-directing effect seen in osmium tetroxide-mediated dihydroxylations. Hydroxylamino-propane analogs were also synthesized through similar methodology to afford adenine and cyclopropylamino purine analogs to acyclovir. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Synthesis of dinucleotides containing nitrone, hydroxylamine and amidoxime linkages
  作者：John K Gallos、Constantinos C Dellios

  DOI：10.1016/s0040-4039(03)01355-8

  日期：2003.7

  new thymidine dinucleotides with nitrone, hydroxylamine and amidoxime backbone linkages, suitable for incorporation into oligonucleotide chains, were easily synthesized, by coupling of readily available thymidine monomers and applying short, simple and efficient procedures. (C) 2003 Elsevier Ltd. All rights reserved.
• METHODS OF DEPLETING A TARGET MOLECULE IN A SAMPLE AND KITS FOR PRACTICING THE SAME
  申请人：Clontech Laboratories, Inc.

  公开号：US20140073528A1

  公开（公告）日：2014-03-13

  Provided are methods of depleting a target molecule in a sample. The methods include contacting a target molecule with a free radical-generating system and generating free radicals from the free radical-generating system to deplete the target molecule in the sample. Kits for practicing the subject methods are also provided.