1-(2'-fluoro-biphenyl-4-yl)-ethanol | 345-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2'-fluoro-biphenyl-4-yl)-ethanol
• 英文别名: (+/-)-1-Hydroxy-1-(2'-fluor-biphenylyl-(4))-aethan；(+/-)-2'-Fluor-4-(1-hydroxy-aethyl)-biphenyl；1-(2'-Fluor-biphenyl-4-yl)-aethanol；1-(2'-fluoro[1,1']-biphenyl-4-yl)-ethanol；1-(2'-fluoro-4-biphenylyl)-1-hydroxy-ethane；1-(2'-fluoro-4-biphenylyl)-1-ethanol；1-[4-(2-fluorophenyl)phenyl]ethanol
• CAS: 345-54-0
• 化学式: C₁₄H₁₃FO
• 分子量: 216.255
• InChiKey: TXGWVUKEBDNEBM-UHFFFAOYSA-N

物化性质

• 熔点：
  87 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• 沸点：
  333.6±30.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2'-fluoro-biphenyl-4-yl)-ethanol 在 双氧水 、 对甲苯磺酸 、 calcium oxide 作用下， 以 溶剂黄146 、 二甲基亚砜 、 苯 为溶剂， 生成 [1-(2'-Fluoro-4-biphenylyl)-ethylsulfinyl]-acetic acid n-butyl ester
  参考文献：
  名称：

  FR2271810

  摘要：

  公开号：
• 作为产物：
  描述：

  1-[4-(2-氟苯基)苯基]乙酮 在 乙醇 、 copper oxide-chromium oxide 作用下， 生成 1-(2'-fluoro-biphenyl-4-yl)-ethanol
  参考文献：
  名称：

  Vinyl Aromatic Compounds. III. Fluorinated Derivatives¹

  摘要：

  DOI：

  10.1021/ja01211a008

文献信息

• Dinuclear Tetrapyrazolyl Palladium Complexes Exhibiting Facile Tandem Transfer Hydrogenation/Suzuki Coupling Reaction of Fluoroarylketone
  作者：Niranjan Dehury、Niladri Maity、Suman Kumar Tripathy、Jean-Marie Basset、Srikanta Patra

  DOI：10.1021/acscatal.6b01421

  日期：2016.8.5

  fluoroarylketone: tetrapyrazolyl dipalladium complexes with varying Pd–Pd distances efficiently catalyze the tandem reaction involving transfer hydrogenation of fluoroarylketone to the corresponding alcohol and Suzuki–Miyaura cross-coupling reaction of the resulting fluoroarylalcohol under moderate reaction conditions, to biaryl alcohol. The complex with the shortest Pd–Pd distance exhibits the highest tandem

  本文中，我们报告了一个基于双核吡唑基的Pd配合物对氟代芳基酮进行串联催化的例子：具有不同Pd-Pd距离的四吡唑基二钯配合物有效地催化了串联反应，该反应涉及将氟代芳基酮氢化转移至相应的醇和Suzuki-Miyaura交叉偶联在适中的反应条件下将所得的氟代芳基醇反应成联芳基醇。Pd–Pd距离最短的配合物在其双金属类似物中表现出最高的串联活性，就活性和选择性而言，它超过了类似的单核化合物。该反应的动力学清楚地表明，卤代芳基酮还原成卤代醇是串联反应中决定速率的步骤。有趣的是，当氟代芳基酮经历多步串联催化时，氯代和溴代芳基酮仅经历单步CC偶联反应，最终生成联芳基酮。与基于吡唑的Pd化合物不同，前驱体PdCl2和膦基相关配合物（PPh 3）2 PdCl 2和（PPh 3）4 Pd不能表现出串联催化作用。
• 3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof
  申请人：Boehringer Ingelheim GmbH

  公开号：US03987197A1

  公开（公告）日：1976-10-19

  3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof formed with inorganic or organic bases; the compound as well as its salts are useful as antiphlogistics and antirheumatics.

  3-(2'-氟-4-联苯基)-丁酸及其与无机或有机碱形成的盐；该化合物及其盐可用作抗炎和抗风湿药物。
• Biphenyl derivatives
  申请人：Boehringer Ingelheim GmbH

  公开号：US04191776A1

  公开（公告）日：1980-03-04

  Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, methyl, methoxy, methylthio or cyano; R.sub.2 is hydrogen or fluorine; R.sub.3 is carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl or pyridyl-methoxy-carbonyl, A is (alkyl of 1 to 3 carbon atoms)-methylene, m is 1 or 2; and n is 0, 1, 2 or 3; and, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.

  式为##STR1##的化合物，其中R.sub.1为氢、氟、氯、溴、甲基、甲氧基、甲硫基或氰基；R.sub.2为氢或氟；R.sub.3为羧基、(1至6个碳原子的烷氧基)-羰基、甲氧基-(1至6个碳原子的烷氧基)-羰基、(2至6个碳原子的烯烃氧基)-羰基、(7至12个碳原子的芳基氧基)-羰基、苯氧基-羰基或吡啶基-甲氧基-羰基，A为(1至3个碳原子的烷基)-亚甲基，m为1或2；n为0、1、2或3；当R.sub.3为羧基时，与无机或有机碱形成的非毒性盐。这些化合物及盐可用作抗血栓、抗胆固醇和抗凝剂。
• Biphenylyl derivatives
  申请人：Boehringer Ingelheim GmbH

  公开号：US03993683A1

  公开（公告）日：1976-11-23

  Compounds of the formula ##SPC1## Wherein R.sub.1 is hydrogen, fluorine, bromine, methyl, methoxy, methylthio, nitro, cyano or, when A is other than methylene, R.sub.2 is hydrogen, R.sub.3 is carboxyl, m is 2 and n is 0, also chlorine; R.sub.2 is hydrogen or fluorine; R.sub.3 is hydrogen, methyl, hydroxymethyl, carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl, pyridylmethoxy-carbonyl, amino-carbonyl, (alkyl of 1 to 3 carbon atoms-amino)-carbonyl, (dialkyl of 1 to 3 carbon atoms-amino)-carbonyl, phenylamino-carbonyl, morpholino-carbonyl, piperidino-carbonyl, thiomorpholino-carbonyl, (1-oxidothiomorpholino)-carbonyl or (1,1-dioxido-thiomorpholino)-carbonyl; A is methylene, (alkyl of 1 to 3 carbon atoms)-methylene, di-(alkyl of 1 to 3 carbon atoms)-methylene, hydroxymethyl-methylene, hydroxymethylene or carbonyl; m is 1 or 2; and n is 0, 1, 2 or 3; And, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.

  式为##SPC1##的化合物，其中R.sub.1为氢、氟、溴、甲基、甲氧基、甲硫基、硝基、氰基或当A不是亚甲基时，R.sub.2为氢，R.sub.3为羧基，m为2，n为0，还有氯；R.sub.2为氢或氟；R.sub.3为氢、甲基、羟甲基、羧基、（1至6个碳原子的烷氧基）-羰基、甲氧基-（1至6个碳原子的烷氧基）-羰基、（2至6个碳原子的烯氧基）-羰基、（7至12个碳原子的芳基氧基）-羰基、苯氧基-羰基、吡啶甲氧基-羰基、氨基-羰基、（1至3个碳原子的烷基氨基）-羰基、（1至3个碳原子的二烷基氨基）-羰基、苯基氨基-羰基、吗啉基-羰基、哌啶基-羰基、硫吗啉基-羰基、（1-氧代硫吗啉基）-羰基或（1,1-二氧代硫吗啉基）-羰基；A为亚甲基，（1至3个碳原子的烷基）-亚甲基，二（1至3个碳原子的烷基）-亚甲基，羟甲基-亚甲基，羟亚甲基或羰基；m为1或2；n为0、1、2或3；当R.sub.3为羧基时，与无机或有机碱形成的非毒性盐。这些化合物以及盐可用作抗血栓、抗胆固醇和抗凝剂。
• Facile tandem Suzuki coupling/transfer hydrogenation reaction with a bis-heteroscorpionate Pd–Ru complex
  作者：Niranjan Dehury、Suman Kumar Tripathy、Anupam Sahoo、Niladri Maity、Srikanta Patra

  DOI：10.1039/c4dt02465f

  日期：——

  A bis-heteroscorpionate Pd–Ru complex (1) is developed which shows efficient tandem Suzuki coupling/transfer hydrogenation reaction towards a broad range of substrates.

  开发了一种双异构蝎合物Pd-Ru配合物（1），它对广泛的底物表现出高效的串联Suzuki偶联/转移氢化反应。