(±)-9,10-dihydroxy-12Z-octadecenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (±)-9,10-dihydroxy-12Z-octadecenoic acid
• 英文别名: (12Z)-9,10-dihydroxy-12-octadecenoic acid；9,10-dihydroxy-12(Z)-octadecenoic acid；9,10-dihydroxy-12Z-octadecenoic acid；9,10-dihydroxy-12-octadecenoic acid；9,10-dihydroxyoctadec-12-enoic acid；kairomone；(12Z)-9,10-Dihydroxyoctadec-12-enoic acid；(Z)-9,10-dihydroxyoctadec-12-enoic acid
• 化学式: C₁₈H₃₄O₄
• 分子量: 314.466
• InChiKey: XEBKSQSGNGRGDW-YFHOEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (±)-9,10-dihydroxy-12Z-octadecenoic acid 生成 己二酸
  参考文献：
  名称：

  JAIN, PRAVEEN;IQBAL, S. A., ORIENTAL -J. CHEM., 5,(1989) N, C. 200-203

  摘要：

  DOI：
• 作为产物：
  描述：

  9-10-单环氧-12-十八碳烯酸 生成 (±)-9,10-dihydroxy-12Z-octadecenoic acid
  参考文献：
  名称：

  JAIN, PRAVEEN;IQBAL, S. A., ORIENTAL -J. CHEM., 5,(1989) N, C. 200-203

  摘要：

  DOI：

文献信息

• Pharmaceutical compositions of a 105 kD P. Haemolytica derived antigen
  申请人：Board of Regents, The University of Texas System

  公开号：US04957739A1

  公开（公告）日：1990-09-18

  Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell-free Pasteurella haemolytica supernatants are employed to provide individual antigen compositions, identified through reaction with sera from naturally-infected or convalescent cattle. In particular, at least seven individual P. hameolytica antigen groups were recognized in cell-free culture supernatants. Purified P. haemolytica supernatant, formulated in a suitable pharmaceutical vaccine composition is shown to elicit a specific immune response, in both cows and rabbits, directed against the individual immunoreactive P. haemolytica polypeptides identified. Also disclosed are novel recombinant cells, plasmids and bacteriophage which include transcriptionally active P. haemolytica antigen genes. Recombinant clones are similarly selected to be reactive with naturally-infected antisera. Examples, and further disclosure, are also provided which demonstrate the utility of a presently disclosed antibody and antigen compositions in immunodetection of both antigens and antibodies in various biological samples.

  本发明揭示了用于治疗或诊断牛传染性败血症（通常称为运输热）的小说组合物。利用无细胞培养基上清液提供单个抗原组合物，通过与自然感染或康复牛血清反应鉴定。特别地，在无细胞培养基上清液中识别出至少七个单独的P. hameolytica抗原组。经过纯化的P. haemolytica上清液，配制成适当的制药疫苗组合物，被证明能够在奶牛和兔子中引起特异性免疫反应，针对已经鉴定出来的单个免疫反应性P. haemolytica多肽。此外，本发明还揭示了包括转录活性P. haemolytica抗原基因的新型重组细胞、质粒和噬菌体。重组克隆同样被选中与自然感染抗血清反应。本发明还提供了例子和进一步的披露，证明了目前披露的抗体和抗原组合物在各种生物样本中的免疫检测中的效用。
• Metabolite biomarkers for diseases associated with the contact activation system
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US11340237B2

  公开（公告）日：2022-05-24

  Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.

  本文提供的方法和试剂盒用于分析从患有、疑似患有或有可能患有与接触激活系统有关的疾病的受试者处获得的生物样本。
• Molecular characterization of NbEH1 and NbEH2, two epoxide hydrolases from Nicotiana benthamiana
  作者：Fong-Chin Huang、Wilfried Schwab

  DOI：10.1016/j.phytochem.2013.02.020

  日期：2013.6

  Plant epoxide hydrolases (EH) form two major clades, named EH1 and EH2. To gain a better understanding of the biochemical roles of the two classes, NbEH1.1 and NbEH2.1 were isolated from Nicotiana benthamiana and StEH from potato and heterologously expressed in Escherichia coli. The purified recombinant proteins were assayed with a variety of substrates. NbEH1.1 only accepted some aromatic epoxides, and displayed the highest enzyme activity towards phenyl glycidyl ether. In contrast, NbEH2.1 displayed a broad substrate range and similar substrate specificity as StEH. The latter enzymes showed activity towards all fatty acid epoxides examined. The activity (V-max) of NbEH1.1 towards phenyl glycidyl ether was 10 times higher than that of NbEH2.1. On the contrary, NbEH2.1 converted cis-9,10-epoxystearic acid With V-max of 3.83 mu mol min mg(-1) but NbEH1.1 could not hydrolyze cis-9,10-epoxystearic acid. Expression analysis revealed that NbEH1.1 is induced by infection with tobacco mosaic virus (TMV) and wounding, whereas NbEH2.1 is present at a relatively constant level, not influenced by treatment with TMV and wounding. NbEH1.1 transcripts were present predominantly in roots, whereas NbEH2.1 mRNAs were detected primarily in leaves and stems. Overall, these two types of tobacco EH enzymes are distinguished not only by their gene expression, but also by different substrate specificities. EH1 seems not to participate in cutin biosynthesis and it may play a role in generating signals for activation of certain defence and stress responses in tobacco. However, members of the EH2 group hydrate fatty acid epoxides and may be involved in cutin monomer production in plants. (C) 2013 Elsevier Ltd. All rights reserved.
• Fukushima, Jun-ichi; Kuwahara, Yasumasa; Suzuki, Takahisa, Agricultural and Biological Chemistry, 1989, vol. 53, # 11, p. 3057 - 3060
  作者：Fukushima, Jun-ichi、Kuwahara, Yasumasa、Suzuki, Takahisa

  DOI：——

  日期：——
• TREATING PULMONARY DISEASES MEDIATED BY POLYUNSATURATED LIPID METABOLITES AND ASSAYS FOR EPOXIDE HYDROLASE INHIBITORS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0926951B1

  公开（公告）日：2004-04-21