A method of producing a protein that degrades or detoxifies organic material is described. This method involves producing a non-human transgenic animal that produces such protein in its urine, and has stably integrated into its genome an exogenous gene encoding a protein that is detectable in the urine. Thus, a non-human transgenic animal that produced such protein in its urine, and a method of degrading or detoxifying organic materials also is described. Also a facility comprising a non-human transgenic animal that produce in its urine a protein that degrades or detoxifies organic material and a structure containing such animal is described. A method of altering a substance naturally found in urine is described. A DNA construct used in producing the non-human transgenic animal also is described.
本文介绍了一种生产能降解或解毒有机物的蛋白质的方法。这种方法包括生产一种非人类转
基因动物,这种动物在其尿液中产生这种蛋白质,并将编码尿液中可检测到的蛋白质的外源
基因稳定地整合到其
基因组中。因此,本文还描述了一种在其尿液中产生这种蛋白质的非人类转
基因动物,以及一种降解或解毒有机物的方法。此外,还介绍了一种设施,其中包括一种在其尿液中产生可降解有机物或使有机物解毒的蛋白质的非人类转
基因动物,以及一种含有这种动物的结构。还介绍了一种改变尿液中天然存在的物质的方法。还描述了用于生产非人类转
基因动物的 DNA 构建物。