2-formylphenyl nicotinate | 7739-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2-formylphenyl nicotinate
• 英文别名: nicotinic acid-(2-formyl-phenyl ester)；Nicotinsaeure-(2-formyl-phenylester)；(2-Formylphenyl) pyridine-3-carboxylate
• CAS: 7739-94-8
• 化学式: C₁₃H₉NO₃
• 分子量: 227.219
• InChiKey: AVIGWSXSPNXTNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-formylphenyl nicotinate 、 4-氨基安替比林 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以75%的产率得到2-[(Z)-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)iminomethyl]phenyl pyridine-3-carboxylate
  参考文献：
  名称：

  Heterocyclic Derivatives of 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

  摘要：

  A convenient and scalable preparative method for the synthesis of azomethines from 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one and substituted benzaldehydes, as well as 1,2-oxazole and 1,2-thiazolecarbaldehyde was developed.

  DOI：

  10.1134/s1070363220080095
• 作为产物：
  描述：

  3-吡啶甲醛 、 水杨醛 在 叔丁基过氧化氢 、 copper diacetate 作用下， 以 水 为溶剂， 反应 2.0h， 以60%的产率得到2-formylphenyl nicotinate
  参考文献：
  名称：

  铜催化邻甲酰基苯酚的氧化酯化反应，而不影响不稳定的甲酰基

  摘要：

  以TBHP为水溶液，开发了铜催化的邻甲酰基苯酚与醛的氧化酯化反应。除了芳族和脂族醛以外，苯甲醇也适用于该反应。敏感的甲酰基在氧化条件下保持完整。该方法为经典的酯化反应提供了另一种方案。

  DOI：

  10.1016/j.tetlet.2015.06.024

文献信息

• Nicotinsäure-phenolester mit antimykotischer und hyperämisierender Wirksamkeit
  作者：Helmut Zinner、Heinz Fiedler

  DOI：10.1002/ardp.19582910704

  日期：——
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE
  申请人：KANDULA MAHESH

  公开号：WO2014087307A2

  公开（公告）日：2014-06-12

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic syndrome and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE
  申请人：KANDULA MAHESH

  公开号：WO2014106804A2

  公开（公告）日：2014-07-10

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic syndrome and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, neuropathic pain, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
• Copper-catalyzed oxidative esterification of ortho-formyl phenols without affecting labile formyl group
  作者：Yong Zheng、Wei-Bin Song、Li-Jiang Xuan

  DOI：10.1016/j.tetlet.2015.06.024

  日期：2015.7

  A copper-catalyzed oxidative esterification of ortho-formyl phenols with aldehydes using TBHP as oxidant in water is developed. Besides aromatic and aliphatic aldehydes, benzylic alcohols are also suitable for this reaction. The sensitive formyl group remains intact under oxidative conditions. This method provides an alternative protocol for classical esterification reactions.

  以TBHP为水溶液，开发了铜催化的邻甲酰基苯酚与醛的氧化酯化反应。除了芳族和脂族醛以外，苯甲醇也适用于该反应。敏感的甲酰基在氧化条件下保持完整。该方法为经典的酯化反应提供了另一种方案。
• Heterocyclic Derivatives of 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
  作者：E. A. Akishina、D. V. Kazak、E. A. Dikusar、E. G. Zalesskaya、N. A. Zhukovskaya、S. G. Stepin、V. I. Potkin

  DOI：10.1134/s1070363220080095

  日期：2020.8

  A convenient and scalable preparative method for the synthesis of azomethines from 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one and substituted benzaldehydes, as well as 1,2-oxazole and 1,2-thiazolecarbaldehyde was developed.