1-palmitoyl-2-linolenoyl-3-acetylglycerol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-palmitoyl-2-linolenoyl-3-acetylglycerol
• 英文别名: (1-acetyloxy-3-hexadecanoyloxypropan-2-yl) (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• 化学式: C₃₉H₆₈O₆
• 分子量: 632.965
• InChiKey: UCLAKHRTNSBSRH-MWSZCINKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.4
• 重原子数：
  45
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甘油棕榈酸酯 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-palmitoyl-2-linolenoyl-3-acetylglycerol
  参考文献：
  名称：

  Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells

  摘要：

  Several monoacetyldiglycerides were synthesized from glycerol in search fbr new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00690-8

文献信息

• PHARMACEUTICAL COMPOSITION CONTAINING EXTRACTS OF CERVUS NIPPON ANTLERS HAVING GROWTH-STIMULATING ACTIVITIES OF HEMATOPOIETIC STEM CELLS AND MEGAKARYOCYTES
  申请人：Jhon, Gil Ja

  公开号：EP1061932A1

  公开（公告）日：2000-12-27
• Methods for Inducing Stem Cell Migration and Specialization with EC-18
  申请人：Hong John J.

  公开号：US20100010087A1

  公开（公告）日：2010-01-14

  The present invention relates to promoting stem cell migration and specialization by administering one or more MADG compounds. The present invention further pertains to repairing or promoting the healing of injured tissue or a wound of an individual by administering a MADG compound (e.g., EC-18) to the individual, or subjecting the injured tissue/wound to a MADG compound. Another aspect of the invention relates to treating disease or conditions that benefit from stem cell therapy by administering MADG with or without exogenous stem cells.
• [EN] PHARMACEUTICAL COMPOSITION CONTAINING EXTRACTS OF CERVUS NIPPON ANTLERS HAVING GROWTH-STIMULATING ACTIVITIES OF HEMATOPOIETIC STEM CELLS AND MEGAKARYOCYTES<br/>[FR] COMPOSITION PHARMACEUTIQUE CONTENANT DES EXTRAITS DE BOIS DE CERVUS NIPPON POSSEDANT UNE ACTIVITE DE STIMULATION DE LA CROISSANCE DES CELLULES SOUCHES HEMATOPOIETIQUES ET DES MEGACARYOCYTES
  申请人：BUKWANG PHARM. IND. CO., LTD.

  公开号：WO1999026640A1

  公开（公告）日：1999-06-03

  (EN) The present invention relates to a pharmaceutical composition having growth-stimulating effects on hematopoietic stem cells and megakaryocytes, containing a specific extract or $i(Cervus nippon) antlers, especially a chloroform extract of $i(Cervus nippon) antlers and to a biologically active compound isolated from the extracts of $i(Cervus nippon) antlers, to a process for preparing the biologically active compounds and to a pharmaceutical composition containing the biological active compounds. The biologically active compounds have monoacetyl diglyceride structure with various side branches as shown in formula (I) where R1 is 9-octadecenoyl and R2 is hexadecanoyl (KJ-1), or R1 is hexadecanoyl and R2 is 9-octadecenoyl (KJ-2), or R1 is hexadecanoyl and R2 is 9,12-octadecadienoyl (KJ-3), or R1 is hexadecanoyol and R2 is 9,12,15-optadecatrienoyl (KJ-4), or R1 is hexadecanoyl and R2 is 5,8,11,14-eicosatetraenoyl (KJ-5).(FR) La présente invention concerne une composition pharmaceutique possédant des effets de stimulation de la croissance des cellules souches hématopoïétiques et des mégacaryocytes, et contenant un extrait spécifique des bois du $i(Cervus nippon), en particulier un extrait chloroformique des bois du $i(Cervus nippon). L'invention concerne également un procédé de préparation de composés biologiquement actifs isolés à partir des extraits de bois du $i(Cervus nippon) et une composition pharmaceutique contenant ces composés biologiquement actifs. Lesdits composés présentent une structure de monoacétyl-diglycéride à plusieurs ramifications latérales illustrée dans la formule (I) dans laquelle R1 est un 9-octadécénoyle et R2 est un hexadécanoyle (KJ-1), ou R1 est un hexadécanoyle et R2 est un 9-octadécénoyle (KJ-2), ou R1 est un hexadécanoyle et R2 est un 9,12-octadécadiènoyle (KJ-3), ou R1 est un hexadécanoyle et R2 est un 9,12,15-octadécatriènoyle (KJ-4), ou R1 est un hexadécanoyle et R2 est un 5,8,11,14-eicosatétraènoyle (KJ-5).
• Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells
  作者：So-Yeop Han、So-Hye Cho、So-Yeon Kim、Jeong-Taeg Seo、Seok-Jun Moon、Gil-Ja Jhon

  DOI：10.1016/s0960-894x(98)00690-8

  日期：1999.1

  Several monoacetyldiglycerides were synthesized from glycerol in search fbr new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity. (C) 1998 Elsevier Science Ltd. All rights reserved.