allyl-imidazolidinetrione | 746608-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: allyl-imidazolidinetrione
• 英文别名: Allyl-imidazolidintrion；1-(Prop-2-en-1-yl)imidazolidine-2,4,5-trione；1-prop-2-enylimidazolidine-2,4,5-trione
• CAS: 746608-55-9
• 化学式: C₆H₆N₂O₃
• mdl: MFCD05273653
• 分子量: 154.125
• InChiKey: SKHLVUPSTBNLMM-UHFFFAOYSA-N

物化性质

• 熔点：
  142-145 °C(Solvent: Water)
• 密度：
  1.346±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  allyl-imidazolidinetrione 、 mercury(II) diacetate 在 甲醇 作用下， 生成 2-methoxy-3-(trioxo-imidazolidin-1-yl)-propylmercury (1+); hydroxide
  参考文献：
  名称：

  Mercurial Diuretics¹

  摘要：

  DOI：

  10.1021/ja01638a044
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 、 silver nitrate 作用下， 生成 allyl-imidazolidinetrione
  参考文献：
  名称：

  Endogenous Anticholinergic Substances May Exist During Acute Illness in Elderly Medical Patients

  摘要：

  Background. The purpose of this study was to determine if serum anticholinergic activity (SACA) arises from endogenous substances produced during illness.Methods. Elderly medical inpatients (N = 612) were screened for anticholinergic medication use in the week prior to the study by interviews of subjects and proxies and review of emergency room, hospital, and nursing home medication administration records. Of 24 subjects without a recent anticholinergic medication history, 15 were recruited and 10 completed the study. Serum samples were obtained on Day 2 of hospital admission. SAGA was measured using a radionuclide displacement assay. Medications taken by subjects were assayed for central muscarinic receptor binding at therapeutic concentrations.Results. Eight of the ten subjects had SAGA detectable in the serum. No medication used by these subjects had anticholinergic activity at usual therapeutic concentrations.Conclusions. Endogenous anticholinergic substances may exist during acute illness. Characterization of such substances may increase the depth of our understanding of delirium and lead to useful intervention strategies.

  DOI：

  10.1093/gerona/56.6.m353

文献信息

• Maly, Zeitschrift fur Chemie, 1869, p. 260
  作者：Maly

  DOI：——

  日期：——
• Novel oxaluric acid derivatives and pharmaceutical compositions containing them
  申请人：NIPPON ZOKI PHARMACEUTICAL CO. LTD.

  公开号：EP0191735B1

  公开（公告）日：1990-09-12
• Mercurial Diuretics¹
  作者：L. H. Werner、C. R. Scholz

  DOI：10.1021/ja01638a044

  日期：1954.5
• Endogenous Anticholinergic Substances May Exist During Acute Illness in Elderly Medical Patients
  作者：J. M. Flacker、J. Y. Wei

  DOI：10.1093/gerona/56.6.m353

  日期：2001.6.1

  Background. The purpose of this study was to determine if serum anticholinergic activity (SACA) arises from endogenous substances produced during illness.Methods. Elderly medical inpatients (N = 612) were screened for anticholinergic medication use in the week prior to the study by interviews of subjects and proxies and review of emergency room, hospital, and nursing home medication administration records. Of 24 subjects without a recent anticholinergic medication history, 15 were recruited and 10 completed the study. Serum samples were obtained on Day 2 of hospital admission. SAGA was measured using a radionuclide displacement assay. Medications taken by subjects were assayed for central muscarinic receptor binding at therapeutic concentrations.Results. Eight of the ten subjects had SAGA detectable in the serum. No medication used by these subjects had anticholinergic activity at usual therapeutic concentrations.Conclusions. Endogenous anticholinergic substances may exist during acute illness. Characterization of such substances may increase the depth of our understanding of delirium and lead to useful intervention strategies.