synthesized SM–Chol conjugates with functionally designed linker portions to restrain Chol mobility and examined their formation of orderedmembranes by a detergent insolubility assay, fluorescence anisotropy experiments, and fluorescence‐quenching assay. In all of the tests, membranes prepared from the conjugates showed properties of ordered domains comparable to a SM–Chol (1:1) membrane. To gain insight
Rajora, Sonal; Baregama, Lalit Kumar; Talesara, Journal of the Indian Chemical Society, 2002, vol. 79, # 2, p. 193 - 194
作者:Rajora, Sonal、Baregama, Lalit Kumar、Talesara
DOI:——
日期:——
The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues
作者:Vladimir A Kuksa、Valentin A Pavlov、Paul Kong Thoo Lin
DOI:10.1016/s0960-894x(00)00201-8
日期:2000.6
A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated. All these compounds showed an average GI(50) value in the range of 3.9-28.9 mu M. SAR studies showed that the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity. (C) 2000 Elsevier Science Ltd. All rights reserved.