N-异丙基-4-甲基苯磺酰胺 | 21230-07-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-异丙基-4-甲基苯磺酰胺
• 英文名称: N-isopropyl-p-toluenesulfonamide
• 英文别名: N-isopropyl-4-methylbenzenesulfonamide；4-methyl-N-(1-methylethyl)benzenesulfonamide；4-methyl-N-propan-2-ylbenzenesulfonamide
• CAS: 21230-07-9
• 化学式: C₁₀H₁₅NO₂S
• mdl: MFCD00543042
• 分子量: 213.301
• InChiKey: NXUHAAIJVABUMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  49-50 °C
• 沸点：
  318.9±35.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2935009090
• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P362,P403+P233,P501
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  N-异丙基-4-甲基苯磺酰胺 在 正丁基锂 、 三苯基膦 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 9.0h， 生成 N-(2,2-dichlorovinyl)-N-isopropyl-4-methyl-benzenesulfonamide
  参考文献：
  名称：

  Synthesis of ynamides from formamides

  摘要：

  N-Formyl-tosylamides can be efficiently converted to N-ethynyl-tosylamides in two steps via the corresponding dichlorovinylamides. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.11.091
• 作为产物：
  描述：

  p-Toluolsulfinsaeure-isopropylamid 在 四乙基对甲苯磺酸铵 作用下， 以 甲醇 为溶剂， 以81%的产率得到N-异丙基-4-甲基苯磺酰胺
  参考文献：
  名称：

  Electrochemical Oxidation of N-p-Toluenesulfinamides

  摘要：

  [GRAPHICS]Contrasting and interesting electrochemical behavior is observed in anodic oxidation of N-substituted p-toluenesulfinamides under controlled current conditions. For sulfinamides derived from secondary alkylamines and primary arylamines, the N-sulfinyl group is removed and the corresponding amines are formed; for sulfinamides derived from primary alkylamines, sulfur oxidation yields the corresponding sulfonamides in good yields.

  DOI：

  10.1021/ol0258381

文献信息

• The Mechanism of Alkene Elimination from Protonated Toluenesulphonamides Generated by Electrospray Ionisation
  作者：Amie Saidykhan、Jenessa Ebert、William H.C. Martin、Richard T. Gallagher、Richard D. Bowen

  DOI：10.1255/ejms.1427

  日期：2016.8

  The positive ion electrospray mass spectra of a range of sulphonamides of general structure CH3C6H4SO2NHR1 [R1 = C n H2n+1 (n = 1–7), C n H2n-1 (n = 3, 4), C6H5, C6H5CH2 and C6H5CH(CH3)] and CH3C6H4SO2NR1R2 [R1, R2 = C n H2n+1 (n = 1–8)] are reported and discussed. The protonated sulphonamides derived from saturated primary and secondary aliphatic amines generally fragment to only a limited extent

  一系列一般结构为 CH3C6H4SO2NHR1 [R1 = C n H2n+1 (n = 1–7), C n H2n-1 (n = 3, 4), C6H5, C6H5CH2 和 C6H5CH( CH3)] 和 CH3C6H4SO2NR1R2 [R1, R2 = C n H2n+1 (n = 1–8)] 进行了报道和讨论。除非通过碰撞激发能量，否则衍生自饱和脂肪族伯胺和仲胺的质子化磺酰胺通常仅在有限程度上碎裂。观察到两种一般的断裂：首先，消除烯烃，C n H2n，通过从氮上的 C n H2n+1 烷基之一夺氢获得；其次，裂解形成 CH3C6H4SO2+。通过研究 [M + H – C n H2n]+ 信号强度随氮上烷基取代基结构的变化，以及监测与从质子化的不对称磺酰胺中丢失不同的烯烃，其中两个不同的烷基与氮相连。这种断裂有利于烷基在直接连接到氮的碳原子上的支化，因此表明它涉及一种机制，其中通
• Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides
  作者：Paul T. Marcyk、Latisha R. Jefferies、Deyaa I. AbuSalim、Maren Pink、Mu‐Hyun Baik、Silas P. Cook

  DOI：10.1002/anie.201812894

  日期：2019.2.4

  remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. Described herein is a simple iron-based catalyst system which provides the mild, direct conversion of secondary and tertiary alcohols to sulfonamides. Starting from enantioenriched alcohols, the intramolecular variant

  未活化醇的直接催化取代仍然是有机合成的未开发领域。此外，具有可预测的立体结果的这种困难的亲电试剂的催化活化提出了甚至更大的挑战。本文描述了一种简单的铁基催化剂体系，该体系提供了仲和叔醇向磺酰胺的温和，直接的转化。从富含对映体的醇开始，分子内变体进行立体转化以产生富含对映体的2-和2,2-取代的吡咯烷和二氢吲哚，而无需事先衍生化醇或溶剂化条件。
• Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores
  作者：Yu-Ling Chen、Pankaj Sharma、Rai-Shung Liu

  DOI：10.1039/c5cc09688j

  日期：——

  Gold-catalyzed [2+2+2]-cycloadditions of two discrete ynamides and one one nitrile afford 2,4-diaminopyridine derivatives that are not readily prepared from typical low-valent-metal catalysts. Our mechanistic analysis reveal that the reaction chemoselectivity...

  两个离散的酰胺和一个一个腈的金催化的[2 + 2 + 2]-环加成反应生成2,4-二氨基吡啶衍生物，这些衍生物很难从典型的低价金属催化剂制备。我们的机理分析表明反应的化学选择性...
• TiCl4-Mediated Direct N-Alkylation of Sulfonamides with Inactive Ethers
  作者：Wei Zeng、Jiayan Chen、Ling Dang、Qiang Li、Yong Ye、Shaomin Fu

  DOI：10.1055/s-0031-1290332

  日期：2012.3

  A TiCl4-mediated intermolecular or intramolecular direct N-alkylation reaction of sulfonamides with inactive ethers as alkylating agents was successfully achieved. This method provides a novel approach towards N-alkyl sulfonamides from inactive ethers via an easy workup procedure. N-alkylation - Lewis acid - N-alkyl sulfonamide - dialkyl ether - titanium tetrachloride

  磺酰胺与惰性醚作为烷基化剂的TiCl 4介导的分子间或分子内直接N-烷基化反应已成功实现。该方法提供了一种通过简单的后处理程序从惰性醚制备N-烷基磺酰胺的新颖方法。 N-烷基化-路易斯酸-N-烷基磺酰胺-二烷基醚-四氯化钛
• A palladium-catalyzed regiocontrollable hydroarylation reaction of allenamides with B₂pin₂/H₂O
  作者：Jie Cui、Long Meng、Xiaochen Chi、Qing Liu、Pingping Zhao、Dao-peng Zhang、Lei Chen、Xinjin Li、Yunhui Dong、Hui Liu

  DOI：10.1039/c9cc00797k

  日期：——

  A novel palladium-catalyzed regiocontrollable hydroarylation reaction of allenamides with B2pin2/H2O has been disclosed. H2O as an ideal hydrogen source was activated by B2pin2 to furnish allylamines or enamines with a broad functional group tolerance. The regioselectivity for both of the two products was up to 99 : 1 for most of the examples, which was achieved by adjusting the addition order of the

  已经公开了新颖的钯催化的烯丙基酰胺与B 2 pin 2 / H 2 O的区域可控的氢芳基化反应。作为理想氢源的H 2 O被B 2 pin 2活化，以提供具有宽泛的官能团耐受性的烯丙胺或烯胺。在大多数实施例中，两种产物的区域选择性都高达99：1，这是通过调节催化剂和碘代苯衍生物的加成顺序来实现的。该机制的初步调查证明反应是一个非自由基处理和氘标记的实验表明，氢是选自H 2 O.