γ-(2-methoxyethyl)-L-glutamate N-carboxyanhydride | 1136297-21-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-(2-methoxyethyl)-L-glutamate N-carboxyanhydride
• 英文别名: 2-methoxyethyl 3-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]propanoate
• CAS: 1136297-21-6
• 化学式: C₉H₁₃NO₆
• 分子量: 231.205
• InChiKey: JLGJEYJCGBXSMY-LURJTMIESA-N

物化性质

• 密度：
  1.268±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  L-谷氨酸 在 硫酸 作用下， 以 四氢呋喃 为溶剂， 生成 γ-(2-methoxyethyl)-L-glutamate N-carboxyanhydride
  参考文献：
  名称：

  Thermoresponsive Polypeptides from Pegylated Poly-l-glutamates

  摘要：

  The synthesis and characterization of new thermoresponsive pegylated poly-L-glutamate (poly-L-EG(x)Glu) are described. The obtained polypeptides display low critical solution temperature (LCST) behaviors in water, and the LCST can be tuned via copolymerization of different amino acid monomers at varied molar ratio. This is the first example of thermoresponsive polypeptide made from ring-opening polymerization of alpha-amino acid N-carboxyanhydrides (NCAs). Circular dichroism characterizations reveal that the secondary structure of poly-L-EG(x)Glu depended on the chain length of the side chain.

  DOI：

  10.1021/bm200849m

文献信息

• [EN] NON-IONIC AND THERMORESPONSIVE DIBLOCK COPOLYPEPTIDE HYDROGELS FOR DELIVERY OF MOLECULES AND CELLS<br/>[FR] HYDROGELS DE COPOLYPEPTIDES DOUBLE BLOCS, NON-IONIQUES ET THERMOSENSIBLES, POUR L'ADMINISTRATION DE MOLÉCULES ET DE CELLULES
  申请人：UNIV CALIFORNIA

  公开号：WO2016054432A1

  公开（公告）日：2016-04-07

  The present invention is directed to copolypeptide hydrogels (DCH) containing non-ionic hydrophilic residues (DCHEO ), incorporation of thermoresponsive elements into DCHEO, to generate thermoresponsive DCH (DCHT), and hydrogels that include a combination of DCHEO and DCHT. The invention includes preparation, uses, compositions containing the hydrogels and methods of tuning the hydrogels. The hydrogels can be used to deliver an agent or cells to an organism.

  本发明涉及含有非离子亲水残基（DCHEO）的共聚肽水凝胶（DCH），将热响应元素并入DCHEO中，生成热响应DCH（DCHT），以及包括DCHEO和DCHT组合的水凝胶。该发明包括制备、用途、含有水凝胶的组合物以及调节水凝胶的方法。这些水凝胶可用于向生物体传递药剂或细胞。
• Thermoresponsive Polypeptides from Pegylated Poly-<scp>l</scp>-glutamates
  作者：Chongyi Chen、Zhaohui Wang、Zhibo Li

  DOI：10.1021/bm200849m

  日期：2011.8.8

  The synthesis and characterization of new thermoresponsive pegylated poly-L-glutamate (poly-L-EG(x)Glu) are described. The obtained polypeptides display low critical solution temperature (LCST) behaviors in water, and the LCST can be tuned via copolymerization of different amino acid monomers at varied molar ratio. This is the first example of thermoresponsive polypeptide made from ring-opening polymerization of alpha-amino acid N-carboxyanhydrides (NCAs). Circular dichroism characterizations reveal that the secondary structure of poly-L-EG(x)Glu depended on the chain length of the side chain.